Scale-up and scale-down strategies for bioprocesses are the focal topic of the “Himmelfahrtstagung” 2015. Points for discussion include how lab-scale performance can be successfully transferred in production scale. Microbial and fungal processes, biotransformations as well as cell culture problems will be discussed including scale-up/scale-down devices for mimicking and analysing production conditions.
The "Himmelfahrtstagung" – a 3-day annual conference happening the week before Ascension Day – is the main event for Bioprocess and Biochemical engineers in Germany. The conference is organised by the Biochemical Engineering group of DECHEMA – Germany’s Society for Chemical Engineering and Biotechnology. The event is known for its vivid character offering open and constructive discussions extra time.
Transferring bioprocesses from the lab to production is accompanied by chemical, biological and physical impact factors. While lab-scale approaches benefit from high volumetric power input, homogenous mixing and high mass-transfer rates, processes in production-scale are likewise restricted suffering from economical and technical restrictions. As such large-scale bioreactor conditions are inhomogeneous showing gradients of nutrients, dissolved gases, pH etc. Biocatalysts experience these gradients while travelling through different zones inside the reactor. As a consequence, performance data of large scale may differ significantly from those in lab tests.
In the name of the organisation committee we would like to invite you to submit your recent results of this year’s topic. Besides, young scientists are encouraged to report on their research projects covering other fields of biochemical engineering. Related contributions will be considered in the 2nd half of the 3-days event.