Scale-up and scale-down of bioprocesses

Programme

 

Sunday, 10 May 2015
19.30 h Pre Conference Dinner at the Hotel Restaurant (venue)
Special Buffet 16 Euro (Selfpayment)

 

Monday, 11 May 2015
08:20 h Opening
   R. Takors, Universität Stuttgart / W. Blümke, Evonik Industries AG, Hanau/D
08.30 h Keynote
  Scale-up considerations for economic processes in biotechnology
  B. König, BioInvent Berlin GmbH & Sandoz Industrial Products GmbH/D
  Application of scale-up and scale-down criteria
09.15 h Scale down strategies of cell culture processes
  C. Klinger, C. Schmidberger, D. Eisenkraetzer, Roche Diagnostics GmbH, Penzberg/D
09.45 h Scaling immunoconjugation reactors from lab to clinical manufacturing
  H. Brod, J. Kauling, M. Jenne, V. Michele, Bayer Technology Services GmbH, Leverkusen/D
   
10:15 h Coffee Break
   
  Behaviour of biological systems in different scales
10.45 h

Response of Corynebacterium glutamicum to oscillating oxygen and substrate availability in a novel three-compartment scale-down bioreactor

  A. Lemoine, N. Maya, R. Spann, P. Neubauer, S. Junne, TU Berlin/D
11.15 h Experimental analysis of scale-up dependent regulatory phenomena
  M. Löffler, J. Simen, A. Feund, Universität Stuttgart/D; G. Jäger, Universität Tübingen/D; R. Takors, Universität Stuttgart/D
   
11.45 h Coffee Break
   
  Novel reactor concepts for scale-down/scale-up
12.15 h Scale-up compatible mini-HGMS-system for gluconic acid production with magnetizable gold-nanoparticles
  T. Hering, R. Ulber, N. Tippkötter, TU Kaiserslautern/D
12.45 h cGMP compliant upscale of a moss-based photoautotrophic α-galactosidase production process
  H. Niederkrüger, A. Busch, A. Schaaf, T. Frischmuth, greenovation Biotech GmbH, Freiburg/D; C. Koch, T. Pultar, Biomeva GmbH, Heidelberg/D
13.15 h Lunch Break
   
  Novel reactor concepts for scale-down/scale-up
14.15 h The challenge of scaling up photobioreactors - approaches in a small scale for microalgae
   M.L. Socher, F. Krujatz, T. Bley, J. Weber, J. Steingroewer, C. Löser, TU Dresden/D
14.45 h Single-cell bioreactors: cutting edge cultivation devices for the ultimate scale-down of bioprocesses
  A. Grünberger, C. Probst, W. Wiechert, D. Kohlheyer, Forschungszentrum Jülich GmbH/D
15.15 h Scale-up and down of a next generation bioreactor system for high-density animal cell culture: 5 mL - 2500 L
  M. De Jesus, ExcellGene SA, Monthey/CH; M. Kühner, Kühner AG, Birsfelden/CH; F. Wurm, Swiss Federal Institute of Technology Lausanne (EPFL)/CH
   
15.45 h Coffee Break
   
  Computational tools for scale-up and scale-down
16.15 h Computation-driven scale-down of fermentation
  W. Van Winden, A. Deshmukh, DSM Biotechnology Center, Delft/NL; W. Van Gulik, S. Heijnen, R. Mudde, C. Haringa, TU Delft/NL; M. Reuss, Universität Stuttgart/D; J. Chu, J. Xia, W. Tang, East China University of Science and Technology, Shanghai/CHN; H. Noorman, DSM Biotechnology Center, Delft/NL
16.45 h How can computational fluid dynamics be used in order to rapidly expand bone-marrow derived hMSCs in clinically relevant numbers?
  V. Jossen, A. Ott, Zurich University of Applied Sciences, Wädenswil/CH; C. van den Bos, Lonza Cologne GmbH/D; D. Eibl, R. Eibl, Zurich University of Applied Sciences, Wädenswil/CH
17.15 h Computational fluid dynamics (CFD) as a tool to improve scale-up and scale-down of processes in the pharmaceutical industry
  T. Wucherpfennig, J-E. Schaefer, M. Berger, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss/D
   
17:45 h Meeting of the working party "Bioprozesstechnik"
17:45 - 19:45 h Poster Party with Beer and Brezel

 

 

Tuesday, 12 May 2015
08.30 h

Stirred, not shaken; unsolved issues and new problems in scale-down for scale-up.

  A. Nienow, University of Birmingham/UK
   
  Industrial scale up and scale down case studies
09.15 h Down-scaled process development for the production of viral vaccines at high cell-densities
  D. Vazquez, Y. Genzel, Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg/D; M. von Stosch, Universidade Nova de Lisboa/P; I. Jordan, V. Sandig, ProBioGen AG, Berlin/D; U. Reichl, Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg/D
 09.45 h Speed-up your scale-up - from clinic to commercial manufacturing
  T. Peuker, Sartorius Stedim Systems GmbH, Guxhagen/D
   
10.15 h Coffee Break
   
  Industrial scale up and scale down case studies
10.45 hr Industrial scale-up of a co-digestion plant
  Th. Bayer, Infraserv GmbH & Co. Höchst KG, Frankfurt/D
11.15 h Getting small for understanding the big - Scale-down model qualification and use in process characterization
  K. Kaiser, Bayer Pharma AG, Wuppertal/D
11.45 h SDM in industrial cell culture processes - a powerful tool to ensure reliable production in the light of raw material lot-to-lot variations
  M. Jenzsch, M. Kunze, H. Tebbe, Roche Diagnostics GmbH, Penzberg/D
   
12.15 h Lunch Break
   
  Scale-down/scale-up of DSP processes
13.15 h Scale-up of gassing crystallization processes with respect to an optimal product quality
  T. Kleetz, G. Schembecker, K. Wohlgemuth, TU Dortmund/D

 

13.45 h Integration of ATPE and precipitation in the downstream processing of monoclonal antibodies from lab scale to production scale
  T. Wellsandt, P. Gronemeyer, J. Strube, TU Clausthal/D
   
14.15 h Coffee Break
   
  Scale-down/scale-up of DSP processes
14.45 h Optimization of multimodal chromatography in down-scale process development
  J. Paul, M. Meyer, C. Braemer, S. Jensen, G. Cornelissen, Hochschule für Angewandte Wissenschaften Hamburg/D
15.15 h SPTFF - process development and scale up
  T. Bisschop, Merck Chemicals GmbH - Merck Millipore, Schwalbach/D
   
15.45 h Coffee Break
   
  Open Topic
16.15 h Oxyfunctionalization of terpene substrates using fungal enzymes
  R. Leonhardt, T. Seibel, J. Kolwek, U. Krings, R.G. Berger, Universität Hannover/D
16.45 h Morphology engineering of Streptomyces griseus
  J. Moench-Tegeder, R. Krull, TU Braunschweig/D
   
18.00 h Conference Dinner - Dinner Cruise
Meeting point: Landing stage in front of the hotel

 

 

Wednesday, 13 May 2015
08.30 h Posterpresentation - 3 Best Poster
   
  Open Topic
09.00 h Understanding and engineering of Clostridium pasteurianum for new microbial production processes
  W. Sabra, C. Groeger, W. Wang, TU Hamburg-Harburg/D; T. Krieg, D. Holtmann, DECHEMA Forschungsinstitut, Frankfurt/D; R. Reddy-Bommareddy, S. Rappert, A.-P. Zeng, TU Hamburg-Harburg/D
09.30 h Online fluorescence spectroscopy combined with light-induced gene expression in a high-throughput screening system
  G. Wandrey, K. Hoffmann, RWTH Aachen/D; C. Bier, D. Binder, J. Pietruszka, T. Drepper, K.E. Jaeger, Universität Düsseldorf/D; J. Büchs, RWTH Aachen/D
10.00 h Rapid monitoring of biotin-blocked binding sites of streptavidin during fermentation
 

J. Müller, J. Risse, K. Friehs, Universität Bielefeld/D

   
10.30 h Coffee Break
   
  Open Topic
11.00 h New minimal cells for enzymatic synthesis
  I. Sührer, TU München, Garching b. München/D; W. Lubitz, BIRD-C GmbH, Wien/A; D. Weuster-Botz, K. Castiglione, TU München, Garching b. München/D
11.30 h Applications of FTIR spectroscopy for online process analytics
  A. Boos, D. Sellin, J. Fagaschewski, S. Baum, G.M. Shibabaw, S. Bohne, L. Hilterhaus, H.K. Trieu, A. Liese, TU Hamburg-Harburg/D
12.00 h Optimization of hetero- and mixotrophic cultivation of the red alga Galdieria sulphuraria using glycerol as a carbon source
  P. Schwerna, J. Wolf, F. Katzschmann, R. Buchholz, S. Stute, Universität Erlangen-Nürnberg/D
   
12.30 h Closing

 

 

 

Veranstaltungen
Jetzt Mitglied werden