Functional Genomics and Proteomics - Applications, Molecular Diagnostics & Personalized Medicine

Lecture Programme

(as of 27 November 2012)

Thursday, 31 January 2013

Friday, 1 February 2013

 


 

Thursday, 31 January 2013

10:30 Welcome address

Defining Diseases

Chair: T.M. Gress, Marburg University Hospital

10:40 Detection and characterization of disease genes in pancreatic cancer through serial
           gene 
expression profiling and parallelized functional assays
           S. Melchisedech, T. Honstein, R. Kreider, University Marburg; B. Sipos, J. Sperveslage,
           University of Tübingen; N. Giese, University of Heidelberg; T.M. Gress, M. Buchholz,
           Marburg University Hospital

11:00 In vivo RNAi screen identifies tumor suppressors in breast cancer
          J. Wolf, German Cancer Research Center, Heidelberg; F. Zhang, M.G. Shahmorad,
          MD Anderson Cancer Center, Houston, TX/USA; C. Flechtenmacher, University Hospital,
          Heidelberg; G. Mills, MD Anderson Cancer Center, Houston, TX/USA; K. Müller-Decker,
          J.D. Hoheisel, M. Böttcher, German Cancer Research Center, Heidelberg

11:20 Profiling signal transduction pathways in human tumours: hundreds of "Westerns"
           from laser capture dissected samples

           F. Treindl, Y. Heubach, NMI Natural and Medical Sciences Institute at University of
           Tübingen; S. Schultz, T. Fehm, H. Neubauer, Tübingen University Clinic; M.F. Templin, NMI
           Natural and Medical Sciences Institute at University of Tübingen

11:40 Coffee break and poster viewing

Protein Biomarkers
Chair: M. Buchholz, Marburg University Hospital

12:00 Autoantibody signatures of rheumatoid arthritis patients identified with a bead-based
           assays approach

           H. Goehler, J. Schwermann, M. Gamer, K. Marquardt, A. Telaar, D. Chamrad, C. Theek,
           A. Lueking, Protagen AG, Dortmund; J. Fischer, M. Schneider, University Hospital
           Düsseldorf; P. Schulz-Knappe, Protagen AG, Dortmund

12:20 Identification of autoantibody biomarkers for prostate cancer screening using protein
           microarrays

           J. Luna Coronell, M. Gamperl, R. Kulovics, AIT Austrian Institute of Technology GmbH,
           Vienna/A; P. Hofer, A. Gsur, Medical University Vienna/A; J. Hofbauer, F. Längle,
           Landesklinikum Wiener Neustadt/A; A. Weinhäusel, AIT Austrian Institute of Technology
           GmbH, Vienna/A

12:30 Protein biomarker signature for risk classification of ERalpha positive breast cancer
           patients identified using reverse phase protein arrays

          J. Sonntag, C. Bender, German Cancer Research Center, Heidelberg; S. Aulmann,
          University of Heidelberg; S. von der Heyde, M. Nietert, University Medical Center Göttingen;
          A. Lier, German Cancer Research Center, Heidelberg; B. Burwinkel, University of
          Heidelberg; S. Wiemann, German Cancer Research Center, Heidelberg; T. Beissbarth,
          University Medical Center Göttingen; H.P. Sinn, A. Schneeweiss, University of Heidelberg;
          U. Korf, German Cancer Research Center, Heidelberg

12:50 Lunch

14:15 PLENARY LECTURE
           Chair: T. Herget, Merck KGaA, Darmstadt

           Diagnostic reaches pharmacy - treating patients instead of treating diseases
          
T. Dingermann, Goethe University Frankfurt am Main

Modelling
Chair: T. Herget, Merck KGaA, Darmstadt

15:00 A Boolean model of the cardiac gene regulatory network determining first and second
           heart field identity

           A. Groß, F. Herrmann, D. Zhou, H.A. Kestler, M. Kühl, Ulm University

15:10 Dynamic multi-scale modeling for individualized spatiotemporal prediction of drug
           effects

          J. Diaz Ochoa, J. Bucher, J. Niklas, K. Mauch, Insilico Biotechnology AG, Stuttgart

15:30 A model of the DNA damage response (DDR) regulatory network in aging
           A. Scheffold, C. Müssel, F. Herrmann, K.L. Rudolph, H.A. Kestler, Ulm University

15:40 Coffee break and poster viewing

16:10 PLENARY LECTURE
           Chair: M. Hrabĕ de Angelis, German Research Center for Environmental Health, Munich,
           and TU München

           System-based biomedicine
           R. Balling, Luxembourg Centre for Systems Biomedicine/L

16:55 PANEL DISCUSSION
           Personalized medicine - pros and cons
           Rudi Balling, Luxembourg Centre for Systems Biomedicine/L
           Thomas Gress, Marburg University Hospital
           Martin Hrabĕ de Angelis, German Research Center for Environmental Health, Munich, and
           TU München (moderation)
           Bruce Quinn, Foley Hoag LLP, Boston, MA/USA

18:00 Poster party

20:30 End of the first day


 

Friday, 1 February 2013

Tools
Chair: T. Joos, NMI Natural and Medical Sciences Institute, Reutlingen

 09:30 Improving the biomarker validation by a cross-platform comparison
            K. Köhler, H. Seitz, Fraunhofer Instiute for Biomedical Engineering, Potsdam

 09:40 Impedance sensing in trans-well chambers shows metastasis promoting potential of
           mesenchymal stem cells

           F. Graf, German Cancer Research Center & Mannheim University of Applied Sciences,
           Heidelberg; M. Boutros, German Cancer Research Center & Heidelberg University;
           C. Maercker, Mannheim University of Applied Sciences & German Cancer Research
           Center Heidelberg

 09:50 Technical realization of a new synthetic bio production system generating human
             tumor specific targeted cytokines in personalized medicine

             N. Klehr, L. Bauer, H. Focke, B. Brüderl, J. Setter, Dr. Klehr Institut für Immunologie und
             Zellbiologie, Munich

 10:00 High throughput in vitro antibody generation for gene function analysis
           
S. Dübel, Technische Universität Braunschweig

 10:20 Coffee break and poster viewing

 Protein Microarrays
Chair: J.D. Hoheisel, German Cancer Research Center, Heidelberg

 10:50 On demand protein arrays for personalised proteomics - a progress report
            R. Schmidt, D. Kastelic, E. Cook, M.J. Taussig, O. Stoevesandt, Babraham Institute,
            Cambridge/UK

11:00 Creating protein patterns with light by maskless projection lithography
           B. Waterkotte, A. Waldbaur, B.E. Rapp, Karlsruhe Institute of Technology, Eggenstein-
           Leopoldshafen; K. Schmitz, Technical University of Darmstadt

11:10 Pitfalls and payoffs in relative protein quantification using protein microarrays
            R. Wellhausen, H. Seitz, Fraunhofer Institute for Biomedical Engineering IBMT,
            Potsdam-Golm

 11:20 Antibody microarray proteomics of pancreatic cancer cells under the effect of stromal
            secretory mediators

            A. Yildirim, A. Marzoq, M.S.S. Alhamdani, J.D. Hoheisel, German Cancer Research Center,
           Heidelberg

 11:30 PLENARY LECTURE
            Chair: T. Joos, NMI Natural and Medical Sciences Institute, Reutlingen

            Genomic tests: the impact of pharmacoeconomic and comparative effectiveness
            studies
 on adoption
            B. Quinn, Foley Hoag LLP, Boston, MA/USA

 12:15 Poster Prizes

 12:30 Closing remarks

 12:35 Lunch and end of the conference

 

 

 

 

 

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