Functional Genomics and Proteomics - Applications, Molecular Diagnostics & Next Generation Sequencing

Lecture Programme

Thursday, February 2, 2012

10:30  Welcome address

Molecular Diagnostics

Chair: J.D. Hoheisel, German Cancer Research Center, Heidelberg

10:40 Differentiation of murine ESCs to cardiomyocytes: miRNA profiling, transcriptome
           analysis and their interaction

          L. Gan, RWTH Aachen; S. Schwengberg, Axiogenesis AG, Cologne; B. Denecke, RWTH
          Aachen

11:00  Somatic mutations in acute promyelocytic leukemia (APL) identified by exome
            sequencing

            P.A. Greif, LMU Munich / Helmholtz Zentrum Munich; M. Yaghmaie, Tehran University of
            Medical Sciences/IR; N.P. Konstandin, LMU Munich / Helmholtz Zentrum Munich;
            K. Alimoghaddam, A. Ghavamzadeh, Tehran University of Medical Sciences; A. Hauser,
            A. Graf, S. Krebs, H. Blum, LMU Munich; S.K. Bohlander, LMU Munich / Helmholtz Zentrum
            Munich

11:20  Fully-automated electrochemical biochip platform for rapid, simultaneous and
            sensitive bioagent detection

            C. Pöhlmann, T. Elßner, Bruker Daltonik GmbH, Leipzig

11:40 Coffee break and poster viewing

Proteome-based Diagnostics

Chair: T. Joos, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen

12:00 Parallel proteomics and gene expression analysis of breast cancer
           J. Budczies, C. Denkert, Charité - Universitätsmedizin Berlin; O. Fiehn, B. Perroud,
           University of California, Davis, CA/USA

12:20 Identification of drug-associated proteins in NSCLC xenograft models by
           reverse-phase-protein-arrays

           H. Hülsmann, German Cancer Research Center / National Center for Tumor Diseases,
           Heidelberg; C. Bender, German Cancer Research Center, Heidelberg; J. Rolff,
           Experimental Pharmacology & Oncology Berlin-Buch GmbH / Max-Delbrück-Center, Berlin;
           I. Fichtner, Max-Delbrück-Center, Berlin; R. Herwig, MPI for Molecular Genetics, Berlin;
           U. Korf, German Cancer Research Center, Heidelberg; H. Sültmann, R. Kuner, German
           Cancer Research Center / National Center for Tumor Diseases, Heidelberg

12:40  Systematic high-throughput / high content analysis of the immune-proteome using
            chip-based arrays and bead-based suspension arrays

            H. Goehler, J. Schwermann, P. Pews, V. Trappe, K. Marquardt, D. Chamrad, A. Lueking,
            P. Schulz-Knappe, Protagen AG, Dortmund; T. Joos, N. Schneiderhan-Marra, NMI Natural
            and Medical Sciences Institute at the University of Tübingen, Reutlingen

13:00  Lunch

Network Molecular Diagnostics

Chiar: T. Gress, Marburg University Hospital

14:30  Challenges in the planning and statistical analysis of diagnostic studies
             A. Ziegler, Universität zu Lübeck

15:00  Validation of biomarkers: challenges from the pharmaceutical industry view
           
K. Dücker, Merck KGaA, Darmstadt

15:20  Validation of biomarkers: life cell-based assay for the detection of functionally
            activating adrenoceptor autoantibodies in heart failure

            R. Jahns, Würzburg University Hospital

15:40  Pitfalls and perspectives of molecular diagnostics studies: a personal view
            M. Stürzl, University of Erlangen-Nuremberg

16:00  Coffee break and poster viewing

16:30  PLENARY LECTURE
            Chair: M. Hrabĕ de Angelis, German Research Center for Environmental Health, Munich
            & TU München

            The dynamic of epigenomic landscapes in development and disease
           J. Walter, University of Saarland, Saarbrücken

17:15  PANEL DISCUSSION
            Systems biology - fact or fiction?

18:15  Poster party

20:30  End of the first day


Friday, February 3, 2012


Functional Analyses

Chair: M. Buchholz, Marburg University Hospital

9:15  Effective lead selection for improved protein production in Aspergillus niger based on
          integrated genomics

          I. Jacobs, M.A. Olsthoorn, DSM Biotechnology Center, Delft/NL; I. Maillet, DSM Nutritional
          Products, Basel/CH; M. Akeroyd, S. Breestraat, DSM Biotechnology Center, Delft/NL;
          A.M.J.J. Cees, R. Kooistra, Leiden University/NL; H. Menke, DSM Biotechnology Center,
          Delft/NL; W. Muller, Utrecht University/NL; N.M.E. Peij, DSM Biotechnology Center, Delft/NL;
          A. Ram, Leiden University/NL; J. Verkleij, Utrecht University/NL; H.J. Pel, H. Stam,
          C.M.J. Sagt, DSM Biotechnology Center, Delft/NL

9:35  Personalised shRNA libraries - ENTRACE technology for functional screening in
          tumours

          C. Schmees, H. Volkmer, K.A. Boehme, NMI Natural and Medical Sciences Institute at the
          University of Tübingen, Reutlingen

9:55  Essential genes and synthetic lethality in pancreatic cancer
          J. Fredebohm, M. Böttcher, J.D. Hoheisel, German Cancer Research Center, Heidelberg

10:15 High-throughput analyses of 80 cancer candidate genes reveals a central role for
           Cofilin-1 (CFL1) in regulation of cell proliferation in pancreatic cancer

           S. Melchisedech, T. Honstein, R. Kreider, University of Marburg; B. Sipos, J. Sperveslage,
           University of Tübingen; T. Gress, M. Buchholz, University of Marburg

10:35 Coffee break and poster viewing

11:05  PLENARE LECTURE
            Chair: J.D. Hoheisel, German Cancer Research Center, Heidelberg

            High resolution whole genome analysis and cancer
            I. Gut, National Genome Analysis Centre, Barcelona/E

Target Analysis

Chair: T. Herget, Merck KGaA, Darmstadt

11:50 Monitoring drug effects in preclinical R&D by multiplex indicator protein detection
           J. Schache, Merck Millipore, Darmstadt; F. Zenke, Merck Serono, Darmstadt; B. Becher,
           T. Herget, C. Koemen, Merck Millipore, Darmstadt; G. Kuehn, Merck Serono, Darmstadt;
           S. Kloos, E. Staub, Merck Millipore, Darmstadt; S. Wong, EMD Millipore, Madison, WI/USA;
           V. Wuensche, A. Ososipe, T. Henzler, A. Krog, Merck Millipore, Darmstadt

12:10 Profiling of EGFR phosphorylation in Caco-2 gut epithelial cells upon treatment with
           proinflammatory cytokines

           M. Schmohl, N. Schneiderhan-Marra, NMI Natural and Medical Sciences Institute at the
           University of Tübingen, Reutlingen; M. Blum, G. Stein, M. Schmolz, EDI Experimental and
           Diagnostic Immunology GmbH, Reutlingen; T.O. Joos, NMI Natural and Medical Sciences
           Institute at the University of Tübingen, Reutlingen

12:30 Highly specific activity-based probes for target validation studies of deubiquitinating
           enzymes

           A. Iphöfer, R. Franke, L. Jänsch, Helmholtz Centre for Infection Research, Braunschweig

12:50  Poster awards

13:00 Closing remarks

13:05 Lunch and end of the conference

 

 


 

 

 

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