1st European Conference on Natural Products

Topics

A. Monday, 23 September 2013: Poster Session A

A 01 Biosynthetic studies on fungal meroterpenoids derived from 3,5-dimethylorsellinic acid
Y. Matsuda, T. Awakawa, T. Itoh, T. Wakimoto, The University of Tokyo/J; T. Kushiro, Meiji University, Kanagawa/J; I. Fujii, Iwate Medical University/J; Y. Ebizuka, I. Abe, The University of Tokyo/J
A 02 Evolution of secondary metabolite biosynthesis pathways in marine actinomycetes: Clues from genome mining
S.B. Zotchev, O.N. Sekurova, Norwegian University of Science and Technology, Trondheim/N
A 03 Genome mining of animal and plant pathogenic fungi for bioactive metabolites
Y.H. Chooi, P.S. Solomon, Australian National University, Acton/AUS; Y. Tang, University of California at Los Angeles, CA/USA
A 04 Antimicrobial activity of the extract of Camellia sinensis
I. Savic, V. Nikolic, I. Savic, L. Nikolic, University of Nis, Leskovac/SRB; V. Marinkovic, University of Belgrade/SRB
A 05 Potential anti-inflammatory and gastroprotective properties of a sulfated polysaccharide from brown seaweed of the genus Cystoseira
M. Deghrigue, H. Hadj Ammar, S. Lajili, H. Majdoub, A. Bouraoui, University of Monastir/TN
A 06 Physico-chemical characterization and antioxidant activity of sulfated polysaccharide from brown seaweed of the genus Cystoseira
H. Hadj Ammar, S. Lajili, M. Deghrigue, A. Bouraoui, H. Majdoub, University of Monastir/TN
A 07 Met-cherimolacyclopeptide B and its cyclic peptides analogs: Parallel synthesis and anti-inflammatory activity
A. Dellai, University of Monastir/TN; I. Maricic, V. Kumar, University of California, San Diego, CA/USA; A. Bouraoui, University of Monastir/TN; A. Nefzi, University of California, San Diego, CA/USA
A 08 Targeting the tumor vasculature with pretubulysin - a new vascular disrupting agent
V.K. Kretzschmann, D. Gellrich, University of Munich/D; A. Ullich, Saarland University, Saarbrücken/D; S. Zahler, A.M. Vollmar, University of Munich/D; U. Kazmaier, Saarland University, Saarbrücken/D; R. Fürst, University of Frankfurt/D
A 09 Plant secondary metabolites of different Brassicaceae sprouts
N. Baenas, D.A. Moreno, C. García-Viguera, CEBAS-CSIC, Murcia/E
A 10 Synthesis of optically active natural products using intramolecular SnAr cyclization
Y. Noda, Nihon University, Koriyama/J
A 11 Evaluation of phytochemicals and biochemical activity of native Iberian-American fruits
A. Gironés-Vilaplana, N. Baenas, D. Villaño, CEBAS-CSIC, Murcia/E; H. Speisky, Universidad de Chile, Santiago/RCH; C. Garcia-Viguera, D.A. Moreno, CEBAS-CSIC, Murcia/E
A 12 A phenotypic screening toolbox permits the identification of novel compounds with anti-cancer properties derived from marine fungi
B. Ellinger, European ScreeningPort GmbH, Hamburg/D; J. Landskron, Biotechnology Centre of Oslo/N; A. Prashar, Hypha Discovery Ltd., Uxbridge/UK; J. Silber, Kieler Wirkstoff-Zentrum am Helmholtz-Zentrum für Ozeanforschung (GEOMAR)/D; S. Wrigley, Hypha Discovery Ltd., Uxbridge/UK; K. Tasken, Biotechnology Centre of Oslo/N; A. Labes, Kieler Wirkstoff-Zentrum am Helmholtz-Zentrum für Ozeanforschung (GEOMAR)/D; P. Gribbon, European Screeningport GmbH, Hamburg/D
A 13 Methyl 3-iso-cucurbate, a bolting inhibitor to Brassica rapa.
N. Takada, E. Wakita, E. Yamazaki, M. Hashimoto, Hirosaki University/J; Y. Koda, Hokkaido University, Sapporo/J
A 14 Characterization of angucycline tailoring enzymes
P. Patrikainen, P. Kallio, P. Mäntsälä, J. Niemi, M. Metsä-Ketelä, University of Turku/FIN
A 15 Biotechnological production of sesquiterpenes based on large scale synthesis of FPP and recombinant patchoulol synthase
T. Frister, S. Hartwig, S. Beutel, T. Scheper, Leibniz University Hannover/D
A 16 Structure cytotoxicity relationships of tricyclic clerodane diterpenes
C. De Ford, Freiburg University/D; F. Binns, C. Calderon, R. Murillo, University of Costa Rica, San Jose/CR; M. Könczöl, I. Merfort, Freiburg University/D
A 17 Cranberry proanthocyanidins reduce the
foodborne pathogen Campylobacter

D. Donoghue, A. Woo-Ming, K. Arsi, H. Arambel, P. Blore, University of Arkansas, Fayetteville, AR/USA; A. Donoghue, USDA, Fayetteville, AR/USA
A 18 Functional analysis of prenyltransferses responsible for diterpene biosynthesis in fungi
C. Liu, M. Noike, A. Minami, H. Oikawa, T. Dairi, Hokkaido University, Sapporo/J
A 19 Total synthesis of bernumidine alkaloid from Berberis nummularia
F. Louafi, University of Constantine 1/DZ; J.-P. Hurvois, University of Rennes 1/F
A 20 Genome mining of lasso peptides from Proteobacteria
J. Hegemann, M. Zimmermann, S. Zhu, M. Marahiel, University of Marburg/D
A 21 Synthesis towards crocapeptin A
C. Wuttke, U. Kazmaier, Saarland University, Saarbrücken/D
A 22 Combined induction: A fermentation method for heterologous secondary metabolite production in Streptomyces
H. Onaka, The University of Tokyo/J; Y. Mori, M. Izawa, Toyama Prefectural University/J; S. Hayashi, The University of Tokyo/J
A 23 Steroid compounds from different species of the genus Polygonatum L.
L.N. Gvazava, Institute of Pharmacochemistry, Tbilisi/GE
A 24 Latest insights into biosynthesis of class III lantibiotics - important lead metabolites in Actinomycetes
N. Piwowarska, G.H. Völler, B. Krawczyk, W.M. Müller, R.D. Süssmuth, TU Berlin/D
A 25 Isolation and structure elucidation of new bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire
H. Ben Jannet, S. Ben Salem, A. Jabrane, F. Skhiri-Harzallah, University of Monastir/TN; M-A. Lacaille-Dubois, University of Bourgogne, Dijon/F
A 26 Novel sesquiterpene lactone from the Tunisian
Pulicaria laciniata (Asteraceae): Isolation and structure determination

H. Ben Jannet, H. Ghouila, University of Monastir/TN
A 27 Isolation and structure elucidation of new O-heterosides from the pods of Acacia cyclops
H. Ben Jannet, A. Jelassi, University of Monastir/TN; P. Abreu, Universidade Nova de Lisboa, Caparica/P
A 28 GC, GC-MS and NMR spectroscopy integrated analyses of the Tunisian Pulicaria laciniata root essential oil
H. Ben Jannet, H. Ghouila, University of Monastir/TN
A 29 Structural confirmation of mediomycin A by the genome mining of the biosynthetic gene cluster
L. Zhang, The University of Tokyo/J; T. Ito, Tokushima Bunri University/J; T. Awakawa, T. Wakimoto, The University of Tokyo/J; Y. Asakawa, Tokushima Bunri University/J; I. Abe, The University of Tokyo/J
A 30 Fungus-associated actinomycetes exhibit interaction-specific secondary metabolite spectra
S.D. Schrey, J. Bornikoel, L. Braun, E. Erkenbrack, E. Früh, R. Hampp, H.-P. Fiedler, University of Tübingen/D; M.T. Tarkka, Helmholtz-Zentrum für Umweltforschung, Halle (Saale)/D; N. Horlacher, University of Tübingen/D
A 31 Modulation of secondary metabolites of the plant pathogenic fungus Heterobasidion by Streptomyces sp. AcH 505
N. Horlacher, University of Tübingen/D; J. Nachtigall, TU Berlin/D; R. Hampp, University of Tübingen/D; R. Süßmuth, TU Berlin/D; H.-P. Fiedler, S.D. Schrey, University of Tübingen/D
A 32 Investigation of the memory enhancing effects of the extracts of Centella asiatica (Gotukola)
K. Hamid, I. Ng, J.R. Hanrahan, P.W. Groundwater, The University of Sydney/AUS
A 33 Biological studies of new steroidal glycosides from Caralluma pauciflora
D. Kommidi, H. Kandappa, B. Moodley, N.A. Koorbanally, P. Govender, University of Kwazulu-Natal, Durban/ZA
A 34 Chemical composition of essential oils from the Tunisian Acacia cyanophylla Lindl
A. El Ayeb-Zakhama, L. Sakka -Rouis, University of Monastir/TN; G. Flamini, Dipartimento di Farmacia, Pisa/I; H. Ben Jannet, F. Harzallah-Skhiri, University of Monastir/TN
A 35 Chemical composition and biological activities of essential oils and organic extracts from Allium roseum L.
L. Sakka Rouis, University of Monastir/TN; N. Boughelleb, University of Sousse/TN; A. El Ayeb-Zakhama, University of Monastir/TN; G. Flamini, Dipartimento di Farmacia, Pisa/I; H. Ben Jannet, F. Harzallah-Skhiri, University of Monastir/TN
A 36 Chemical composition and insecticidal activity of Dysphania ambrosioides (L.) Mosyakin & Clemants essential oil
K. Asmi-Benkraiem, University of Monastir/TN; I. Chaieb, Regional Center of Research in Horticulture and Organic Agriculture, Chott-Meriem/TN; A. Nguir, University of Monastir/TN; G. Flamini, Dipartimento di Farmacia, Pisa/I; H. Ben Jannet, F. Harzallah-Skhiri, University of Monastir/TN
A 37 News from polyketide synthase enzymology
K. Koopmans, U. Sundermann, S. Klopries, F. Schulz, TU Dortmund/D
A 38 Chemical composition and phytotoxic effects of essential oils from Ailanthus altissima Miller Swingle
A. El Ayeb-Zakhama, L. Sakka-Rouis, University of Monastir/TN; G. Flamini, Dipartemento di Scienze Farmaceutiche, Pisa/I; H. Ben Jannet, F. Harzallah-Skhiri, University of Monastir/TN
A 39 Cytotoxic conjugates of disorazol Z with the LHRH receptor agonistic peptide D-Lys6-LHRH as targeted therapy of LHRH-R positive tumors
B. Aicher, T. Schuster, Aeterna Zentaris GmbH, Frankfurt am Main/D; A. Schubert, C. Gründker, University of Göttingen/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D and Helmholtz Centre for, Saarbrücken/D; E. Günther, M. Gerlach, M. Teifel, Aeterna Zentaris GmbH, Frankfurt am Main/D
A 40 New bioactive natural products discovery from marine sponge-associated actinomycetes
U. Abdelmohsen, University of Würzburg/D; C. Cheng, University of Strathclyde, Glasgow/UK; E.M. Othman, University of Würzburg/D; M. Szesny, University of Tübingen/D; T. Schirmeister, University of Mainz/D; S. Grond, University of Tübingen/D; H. Stopper, University of Würzburg/D; R. Edrada-Ebel, University of Strathclyde, Glasgow/UK; U. Hentschel, University of Würzburg/D
A 41 Preparation and physicochemical properties of lycopene-loaded nanostructured lipid carriers
S. Okonogi, P. Riangjanapatee, Chiang Mai University/T
A 42 Development of nano-cosmeceutical cream of lycopene
P. Riangjanapatee, S. Okonogi, Chiang Mai University/T
A 43 Synthesis and structural analysis of some monoterpenic ester derivatives of theophylline7-acetic acid
M. Georgieva, Medical University Sofia/BG; Y. Koleva, Prof. Assen Zlatarov University, Bourgas/BG; Al. Zlatkov, Medical University Sofia/BG
A 44 Synthesis and potential drug target identification, using PharmMapper server for group of amide derivatives of diphenylmethylpiperazine
M. Georgieva, B. Zlatkov, Al. Zlatkov, Medical University Sofia/BG
A 45 Functional analysis of prenyltransferase TldC
T. Mori, L. Zhang, T. Awakawa, The University of Tokyo/J; T. Ito, Y. Asakawa, Tokushima Bunri University/J; I. Abe, The University of Tokyo/J
A 46 High-level fermentation of fusicocca-2,10(14)-diene, the shared biosynthetic precursor of the diterpene fusicoccanes
J. Arens, D. Bergs, G. Schembecker, F. Schulz, TU Dortmund/D
A 47 Engineering peptides in vivo: The class II two-component lantibiotic lichenicidin and its derivatives
A. Kuthning, M.P. Exner, A. Denisiuk, N. Budisa, R.D. Süssmuth, TU Berlin/D
A 48 Studies towards the total synthesis of monilicine
C. Wink, S.R. Waldvogel, University of Mainz/D
A 49 Efficient evaluation of healthy tea, gromwell seed against tumor promoting stage
H. Tokuda, T. Arai, Y. Takimoto, J.M. Strong, N. Suzuzki, Kanazawa University/J
A 50 Chemoprevention of leaves of okinawa sweet potato cultuvars, kandabar on in vitro and in vivo carcinogenesis system
H. Tokuda, Kanazawa University/J; N. Oomi, Okinawa Prefectural Agricultural Research Center/J; N. Suzuki, Kanazawa University/J; E. Ichiishii, International University of Health and Welfare Hospital, Kanazawa/J
A 51 Distinct histone amino acids are involved in controling secondary metabolism in Aspergillus nidulans
J. Fischer, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D; H.-W. Nützmann, John Innes Centre, Norwich/UK; K. Scherlach, A.A. Brakhage, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D
A 52 Application of undifferentiated plant cells for the reliable large scale production of natural substances
D. Ullisch, M. Pump, K. Schütte, G. Gorr, Phyton Biotech GmbH, Ahrensburg/D
A 53 Biomimetic synthesis and proposal of relative and absolute stereochemistry of heronapyrrole C
J. Schmidt, C.B.W. Stark, Universität Hamburg/D
A 54 Ultrafast statistical profiling: FT-ICR based profiling of myxobacteria natural products for rapid detection and ID of marker compounds
D. Wunderlich, A. Barsch, Bruker Daltonik GmbH, Bremen/D; D. Krug, T. Hoffmann, Saarland University, Saarbrücken/D; M. Witt, Bruker Daltonik GmbH, Bremen/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D
A 55 Biosynthesis of JBIR-34,35, nonribosomal peptides containing unusual methyloxazoline group
Y. Katsuyama, A. Muliandi, The University of Tokyo/J; M. Izumikawa, Biomedicinal Information Research Center, Tokyo/J; T. Moriya, The University of Tokyo/J; I. Kozone, J. Hashimoto, M. Takagi, K. Shin-ya, Biomedicinal Information Research Center, Tokyo/J; Y. Ohnishi, The University of Tokyo/J
A 56 Recombineering methods promote natural product research
X. Bian, R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D; J. Fu, A.F. Stewart, TU Dresden/D; Y. Zhang, Shandong University, Jinan/CHN
A 57 Electrochemically generated polycyclic phenol oxidation products as starting material for drug synthesis
M. Mirion, S.R. Waldvogel, University of Mainz/D
A 58 Pharmacological properties of an indigenous medicinal plant, Artabotrys crassifolius Hook.f. & Thomson (Annonaceae)
K.K. Tan, T.J. Khoo, C. Wiart, The University of Nottingham Malaysia Campus, Selangor/MAL
A 59 Myxobacterial natural products: The emerging view from comprehensive secondary metabolome analysis
D. Krug, T. Hoffmann, S. Duddela, R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D
A 60 2-acylcyclohexane-1,3-diones from Peperomia trineura and P. alata
E.A. Ferreira, J.B. Reigada, Universidade de São Paulo/BR; M.C.M. Young, Instituto de Botânica, São Paulo/BR; E.F. Guimarães, Instituto de Pesquisa Jardim Botânico, Rio de Janeiro/BR; G.C. Franchi Junior, A.E. Nowill, Universidade de Campinas/BR; J.H.G. Lago, Universidade Federal de São Paulo, Diadema/BR; M.J. Kato, Universidade de São Paulo/BR
A 61 Caffeic acid-derived polymer from bugloss (Anchusa italica Retz.)
L. Amiranashvili, V. Barbakadze, L. Gogilashvili, M. Merlani, K. Mulkijanyan, Tbilisi State Medical University/GE
A 62 The microbial strain collection at the HZI -
uncommon microorganisms as source for new bioactive metabolites

J. Wink, Helmholtz Centre for Infection Research, Braunschweig/D; R. Garcia, R. Ritesh, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D; H. Steinmetz, K.I. Mohr, Helmholtz Centre for Infection Research, Braunschweig/D; D. Krug, J. Herrmann, R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D
A 63 Identification and activation of cryptic gene clusters in Streptomyces fulvissimus
N. Manderscheid, M. Myronovskyi, B. Tokovenko, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Saarbrücken/D; L. Petzke, BASF SE, Ludwigshafen/D; A. Luzhetskyy, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Saarbrücken/D
A 64 The myxobacterial compound chondramide affects actin dynamics in human macrophages and regulates their functions
C. Pergola, K. Schubert, O. Scherer, University of Jena/D; S. Hüttel, Saarland University, Saarbrücken/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; O. Werz, University of Jena/D
A 65 Discovery and characterization of new chondramides with improved bioactivity
J. Herrmann, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D; S. Hüttel, Saarland University, Saarbrücken/D; F. Förster, M. Menhofer, A.M. Vollmar, University of Munich/D; R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland and Saarland University, Saarbrücken/D
A 66 Bioactivity-guided isolation of new secondary metabolites from Myxobacteria
J. Herrmann, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D; J. Wink, H. Steinmetz, R. Jansen, M. Stadler, Helmholtz Centre for Infection Research, Braunschweig/D; R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland and Saarland University, Saarbrücken/D
A 67 Optimizing terpene synthase expression and bioconversion of FPP as a model system for production of high value sesquiterpenes
S. Hartwig, T. Frister, S. Beutel, T. Scheper, Leibniz University of Hannover/D
A 68 Characterization and engineering of cinnabaramide biosynthesis
L. Huo, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D; P. Barbie, U. Kazmaier, Saarland University, Saarbrücken/D; R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D
nach oben

B. Tuesday, 24 September 2013: Poster Session B

B 01 Investigations on rishirilide B biosysnthesis
J. Wunsch-Palasis, University of Freiburg/D; T. Paululat, University of Siegen/D; J. Derochefort, C. Zou, X. Yan, A. Bechthold, University of Freiburg/D
B 02 Linking the actin cytoskeleton to the mitochondrial apoptosis pathway by myxobacterial compound Chondramide A
F. Förster, S. Braig, University of Munich/D; H. Zischka, Helmholtz Zentrum, München/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; A.M. Vollmar, University of Munich/D
B 03 Pretubulysin - a new option for the treatment of metastatic cancer
R.M. Wiedmann, S. Braig, M. Singer, F. Förster, University of Munich/D; U. Kazmaier, Saarland University, Saarbrücken/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; A.M. Vollmar, University of Munich/D
B 04 Synthesis and antimalarial testing of neocryptolepine analogues
W.-J. Lu, L. Wang, Z.-W. Mei, M. Ojima, Okayama University/J; M. Kaiser, Swiss Tropical and Public Health Institute, Basel/CH; I. El Sayed, T. Inokuchi, Okayama University/J
B 05 Design, synthesis, and in-vitro cancer cell growth inhibition evaluation of trioxanes installed in cyclic 2-enoate substructure
M.I. Hossain, Okayama University/J; M. Switalska, Polish Academy of Sciences, Wroclaw/PL; W. Peng, M. Takashima, Okayama University/J; S. Dan, T. Yamori, Japanese Foundation for Cancer Research, Tokyo/J; J. Wietrzyk, Polish Academy of Sciences, Wroclaw/PL; H. Kawafuchi, Toyama National College of Technology/J; T. Inokuchi, Okayama University/J
B 06 Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles
W. Peng, Okayama University/J; M. Switalska, Polish Academy of Sciences, Wroclaw/PL; L. Wang, Y. Edazawa, C.-Q. Pang, I. El-Sayed, Okayama University/J; J. Wietrzyk, Polish Academy of Sciences, Wroclaw/PL; T. Inokuchi, Okayama University/J
B 07 Synthesis and antimalarial testing of isocryptolepine analogues
N. Wang, K. Imai, C.-Q. Pang, M.-Q. Wang, Okayama University/J; M. Kaizer, Swiss Tropical and Public Health Institute, Basel/CH; T. Inokuchi, Okayama University/J
B 08 The macyranines: A heterogeneous peptide family from the myxobacterial genus Cystobacter
L. Etzbach, A. Plaza, R. Garcia, R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D
B 09 Jahnellamides A and B, unusual peptides from the terrestrial Myxobacterium Jahnella sp.: Structure and biosynthesis
A. Plaza, S. Nadmid, K. Viehrig, R. Garcia, R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and Pharmaceutical Biotechnology, Saarbrücken/D
B 10 News from combinatorial biosynthesis: Point mutations as a tool for polyketide diversification
S. Kushnir, TU Dortmund/D; A. Ismail-Ali, U. Sundermann, S. Yahiaoui, MPI of Molecular Physiology, Dortmund/D; F. Schulz, TU Dortmund/D
B 11 Natural products discovery by chemical activation of secondary metabolism in actinomycetes
S. Pimentel-Elardo, A. Craney, McMaster University, Hamilton/CDN; J. Nodwell, McMaster University, Hamilton/CDN and University of Toronto/CDN
B 12 Exploration of new microbial drug source by genome mining: Discovery of nonribosomal peptides from pathogenic Gordonia
T. Fukuda, Toyama Prefectural University/J; H. Komaki, K. Suzuki, National Institute of Technology and Evaluation, Chiba/J; Y. Igarashi, Toyama Prefectural University/J
B 13 Deciphering the chlorotonil biosynthetic pathway in Sorangium cellulosum
K. Jungmann, D. Krug, Saarland University, Saarbrücken/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D
B 14 Hyaladione, an s-methyl cyclohexadiene-dione from the myxobacteria Hyalangium minutum
P.W. Okanya, TU of Kenya, Nairobi/EAK; K.I. Mohr, Helmholtz Centre for Infection Research, Braunschweig/D; V. Huch, Saarland University, Saarbrücken/D; M. Stadler, R. Jansen, R. Müller, Helmholtz Centre for Infection Research, Braunschweig/D
B 15 Characterisation of bacterial terpene synthase products
P. Rabe, J.S. Dickschat, TU Braunschweig/D
B 16 Culture supplement obtained from plant and insect for improving serum-free culture of mammalian cells
S. Terada, University of Fukui/J; M. Taniguchi, Niigata University/J; A. Ogawa, Suzuka National College of Technology/J; K. Kobayashi, Fukui Prefectural Food Processing Research Institute, Sakai/J; M. Sasaki, SEIREN Co. Ltd., Fukui/J; N. Moriyama, ELLE ROSE Co. Ltd., Sakai/J; T. Tsuno, Tsuno Food Industrial Co., Ltd, Wakayama/J
B 17 Juniperolide A: A new polyketide isolated from a terrestrial Actinomycete, Streptomyces sp.
R. Raju, Saarland University, Saarbrücken/D; O. Gromyko, V. Fedorenko, Ivan Franko National University, L'viv/UA; A. Luzhetskyy, A. Plaza, Saarland University, Saarbrücken/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D
B 19 Exploiting plant enzymes for novel bacterial strains producing terpenes
K. Schullehner, G. Jach, Phytowelt GreenTechnologies GmbH, Köln/D
B 20 Novel volatiles from the marine bacterium Streptomyces sp. CNR885
U. Groenhagen, TU Braunschweig/D; W. Fenical, University of California San Diego, La Jolla, CA/USA; S. Schulz, TU Braunschweig/D
B 21 Stimulating encounter: Activation of the silent fumicycline gene cluster in A. fumigatus by S. rapamycinicus
C. König, K. Scherlach, V. Schroeckh, C. Hertweck, A.A. Brakhage, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D
B 22 V-ATPase inhibition regulates anoikis resistance and metastasis of cancer cells
C. Schempp, K. von Schwarzenberg, L. Schreiner, R. Kubisch, University of Munich/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; E. Wagner, A.M. Vollmar, University of Munich/D
B 23 The myxobacterial compound Soraphen A: A potent inhibitor of migration and invasion in breast cancer
K. Ferkaljuk, University of Munich/D
B 24 Pomegranate wine lees as a valuable source of (poly)phenolic compounds
P. Mena, CEBAS-CSIC, Murcia/E; J.A. Ascacio-Valdés, Universidad Autónoma de Coahuila, Saltillo/MEX; D. Del Rio, University of Parma/I; D.A. Moreno, C. García-Viguera, CEBAS-CSIC, Murcia/E
B 25 Bio-inspired formal synthesis of the antitubercular hirsutellone B
B. Nay, X.W. Li, A. Ear, Muséum National d'Histoire Naturelle, Paris/F
B 26 HIF1α induced by V-ATPase inhibition leads to apoptosis in p53 wild type tumor cells
L. Schneider, University of Munich/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; A. Vollmar, K. Von Schwarzenberg, University of Munich/D
B 27 Cytotoxicity of carbazoles and coumarins from the roots of Clausena harmandiana
U. Sriphana, C. Yenjai, Khon Kaen University/T
B 28 Chemical constituents from the stem bark of Toddalia asiatica and their biological activities
R. Phatchana, C. Yenjai, Khon Kaen University/T
B 29 Salimabromide: Unexpected chemistry from the obligate marine myxobacterium Enhygromxya salina
S. Felder, S. Dreisigacker, S. Kehraus, E. Neu, G. Bierbaum, P.R. Wright, D. Menche, T.F. Schäberle, G.M. König, University of Bonn/D
B 30 Unique ß-amino acid biosynthetic pathways involved in bacterial macrolactam polyketides biosynthesis
F. Kudo, M. Takaishi, K. Amagai, T. Eguchi, Tokyo Institute of Technology/J
B 31 The double bond shift in corallopyronin A biosynthesis
T.F. Schäberle, F. Lohr, M. Frizler, University of Bonn/D; P.C. Dorrestein, University of California at San Diego, CA/USA; M. Gütschow, G.M. König, University of Bonn/D
B 32 Photochemical formation of intricarene
D. Stichnoth, T.J. Kimbrough, D. Trauner, University of Munich/D
B 33 Iterative marker excision system for Streptomycetes
M. Myronovskyi, B. Rosenkränzer, A. Luzhetskyy, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Saarbrücken/D
B 34 The diversity of pheromones in wing androconia of
Heliconius butterflies

F. Mann, TU Braunschweig/D; S. Vanjari, C. Jiggins, University of Cambridge/UK; S. Schulz, TU Braunschweig/D
B 35 Biodiversity of Myxobacteria in soil - Evaluation of established cultivation methods by clone bank analyses
M. Stechling, K.I. Mohr, J. Wink, Helmholtz Centre for Infection Research, Braunschweig/D; R. Müller, Helmholtz Institute for Pharmaceutical Research, Saarbrücken/D; M. Stadler, Helmholtz Centre for Infection Research, Braunschweig/D
B 36 An assembly and expression optimization pipeline for biosynthetic pathway reconstitution in microbial cell factories
M. Nielsen, J. Ranberg, S. Seppälä, K. Madsen, U. Christensen, B. Hamberger, B. Møller, M. Nørholm, Danish Technical University, Hørsholm/DK
B 37 Myrtucommulone A induces apoptosis by direct impairment of mitochondrial functions
K. Wiechmann, University of Jena/D; H. Müller, J. Jauch, Saarland University, Saarbrücken/D; O. Werz, University of Jena/D
B 38 Synthesis of optically active crinine-type alkaloid precursors
S. Bernhard, U. Nubbemeyer, University of Mainz/D
B 39 Synthesis of 4-hydroxy-pyran-2-ones by engineered fatty acid megasynthases
J. Gajewski, University of Frankfurt/D; S. Serdjukov, A. Matijczak, Max Planck Institute of Biochemistry, Martinsried/D; N. Cortina, M. Grininger, University of Frankfurt/D
B 40 Identification and synthesis of macrolides produced by mantellid frogs from Madagascar
P.S. Peram, M. Vences, S. Schulz, TU Braunschweig/D
B 41 Cubitanoids: Enantioselective total synthesis of (+)-cubitene and further strategies towards calyculone A
J. Wefer, K. Simon, T. Lindel, TU Braunschweig/D
B 42 Synthesis of optically active natural products using chiral building blocks prepared by enzymatic reaction
Y.M. Mizutani, J.N. Nokami, Okayama University of Science/J
B 43 Novel synthetic chain termination probes for the investigation of polyketide biosynthesis in vivo
J.S. Parascandolo, E. Riva, M. Tosin, University of Warwick, Coventry/UK
B 44 Esca (black measles) of grapevines: The role of secondary metabolites in the plant-pathogen interaction
J. Fischer, S. Schwarz, L. Licht, Institute of Biotechnology and Drug Research, Kaiserslautern/D; B. Berkelmann-Löhnertz, Geisenheim Research Centre/D; L. Sandjo, T. Opatz, University of Mainz/D; A. Schüffler, E. Thines, Institute of Biotechnology and Drug Research, Kaiserslautern/D
B 45 Archazolid inhibits the vacuolar-type ATPase and acts as anti-inflammatory agent in human monocytes
O. Scherer, C. Pergola, University of Jena/D; H. Steinmetz, Helmholtz Centre for Infection Research, Braunschweig/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; H. Kleinert, University of Mainz/D; O. Werz, University of Jena/D
B 46 Optimization of a droplet based ultra-high throughput screening for new antibiotics
L. Mahler, E. Zang, M. Tovar, K. Martin, U. Horn, M. Roth, Leibniz Institute for Natural Product Research and Infection Biology, Jena/D
B 47 Involvement of an iterative type I polyketide synthase in micacocidin biosynthesis
H. Kage, M. Kreutzer, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena/D; D. Hoffmeister, University of Jena/D; M. Nett, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena/D
B 48 Breaking of the regioselectivity of several prenyltransferases by non-natural alkyl donors
M. Liebhold, X. Xie, S.-M. Li, University of Marburg/D
B 49 Two products by one enzyme: Regular C2- and C3-prenylation by the prenyltransferase FtmPT1
B. Wollinsky, X. Xie, S.-M. Li, University of Marburg/D
B 50 Identification of the last gene for the biosynthesis of fumitremorgin A by comparative genomics
K. Mundt, B. Wollinsky, University of Marburg/D; H.-L. Ruan, Huazhong University of Science and Technology, Wuhan/CHN; Q. Gu, Ocean University of China, Qingdao/CHN; S.-M. Li, University of Marburg/D
B 51 Natural product discovery from Myxobacteria by combined screening and production processes
S. Hüttel, Saarland University, Saarbrücken/D; J. Herrmann, Helmholtz Centre for Infection Research, Saarbrücken/D; J. Wink, H. Steinmetz, R. Jansen, M. Stadler, Helmholtz Centre for Infection Research, Braunschweig/D; R. Müller, Helmholtz Centre for Infection Research, Saarbrücken/D
B 52 Nitro versus hydroxamate in siderophores of pathogenic bacteria: Impact of missing hydroxylamine protection in malleobactin biosynthesis
J. Franke, K. Ishida, M. Ishida-Ito, C. Hertweck, Hans-Knöll-Institute, Jena/D
B 53 Total synthesis and target identification of the antibacterial butenolide ramariolide A
J. Lehmann, S.A. Sieber, TU München, Garching/D
B 54 Synthetic studies towards activity based probes for evaluation of protein reactivity of the highly bioactive natural product (-)-nitidon
W. Heydenreuter, S.A. Sieber, TU München, Garching/D
B 55 Caenorhabditis elegans as a model organism for detection of anthelmintic compounds
H. Thomsen, K. Reider, K. Franke, S. Fobofou, L.A. Wessjohann, Leibniz Institute of Plant Biochemistry, Halle/D; J. Keiser, Swiss Tropical and Public Health Institute, Basel/CH; N. Arnold, Leibniz Institute of Plant Biochemistry, Halle/D
B 56 An open implementation of a natural-product-likeness scoring engine
K. Jayaseelan, C. Steinbeck, European Bioinformatics Institute, Cambridge/UK; P. Ertl, Novartis Institutes for BioMedical Research, Basel/CH
B 57 Chemo-microbial synthesis of erythromycin analogs
S. Klopries, U. Sundermann, K. Koopmans, F. Schulz, TU Dortmund/D
B 58 MetaboLights: The secondary metabolome and more
C. Steinbeck, European Bioinformatics Institute (EMBL-EBI), Cambridge/UK
B 59 Fungicidal secondary metabolites from the genus Hygrophorus
A. Otto, A. Teichert, T. Lübken, A. Porzel, J. Schmidt, L. Wessjohann, N. Arnold, Leibniz Institute of Plant Biochemistry, Halle (Saale)/D
B 60 Rational design of new cyanobacterial tricyclic microviridins greatly expands the protease inhibitory activity
S. Meyer, A.R. Weiz, University of Potsdam/D; K. Ishida, C. Hertweck, Hans-Knöll-Institute, Jena/D; E. Dittmann, University of Potsdam/D
B 61 Edible cyanobacteria as a resource for drug discovery
N. Oku, K. Yonejima, M. Matsumoto, Toyama Prefectural University/J; T. Sugawa, Toyama/J; K. Tansei, Suizenjinori-Hompo Tanseido, Kumamoto/J; Y. Igarashi, Toyama Prefectural University/J
B 62 Heterologous expression of biosynthetic genes: Total biosynthesis and genome mining of fungal natural products
K. Tagami, R. Fujii, R. Chiba, C. Liu, A. Minami, M. Noike, Hokkaido University, Sapporo/J; H. Toshima, Ibaraki University, Tsukuba/J; T. Dairi, H. Oikawa, Hokkaido University, Sapporo/J
B 63 Genome mining for drug discovery: Activation of silent biosynthetic gene clusters in Amycolatopsis japonicum
M. Spohn, W. Wohlleben, E. Stegmann, University of Tübingen/D
B 64 Pretubulysin a novel tubulin-antagonist hampers migration and invasion of highly invasive breast cancer cells
R. Kubisch, R. Wiedmann, M. Singer, M. von Gamm, L. Schreiner, S. Braig, E. Wagner, University of Munich/D; U. Kazmaier, Saarland University, Saarbrücken/D; A. Vollmar, University of Munich/D
B 65 Nitrogen metabolism and nitrogen regulation of NAI-107 production in Microbispora ATCC-5024
K. Walter, W. Wohlleben, A. Bera, University of Tübingen/D
B 66 Epigenetic modulation of secondary metabolism in Magnaporthe oryzea
L.P. Sandjo, University of Mainz/D; S. Herbrig, Institute of Biotechnology and Drug Research, Kaiserslautern/D; T. Opatz, University of Mainz/D; E. Thines, Institute of Biotechnology and Drug Research, Kaiserslautern/D
B 67 The myxobacterial compound chondramide shows anti-angiogenic and anti-migratory potency
M. Menhofer, R. Kubisch, L. Schreiner, E. Wagner, University of Munich/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; A.M. Vollmar, S. Zahler, University of Munich/D
B 68 Characterization and engineering of myxopyronin biosynthesis
H. Sucipto, S.C. Wenzel, R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D
B 69 Nogalamycin biosynthesis - discovery of an unusual monooxygenase
V. Siitonen, B. Blauenburg, P. Kallio, P. Mäntsälä, M. Metsä-Ketelä, University of Turku/FIN
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C. Wednesday, 25 September 2013: Poster Session C

C 01 Studies towards the biosynthesis and synthesis of annonaceous acetogenins
J. Adrian, C.B.W. Stark, University of Hamburg/D
C 02 Stimulation of olfactory sesquiterpenes from cell cultures of the agarwood producing plant species Aquilaria filaria
E. Listiana, Jülich Research Center/D; J. Panten, E. Diaz, M. Roloff, Symrise AG, Holzminden/D; B. Muktiono, C. Cerboncini, U. Schurr, Jülich Research Center/D
C 03 To be bald or not to be bald - The bldA gene as a tool to activate cryptic biosynthetic gene clusters in Streptomycetes
A. Gessner, University of Freiburg/D; D.L. Zechel, Queen's University, Kingston/CDN; A. Bechthold, University of Freiburg/D
C 04 Mutasynthesis of tomaymycins: A bimodular NRPS system with remarkable substrate flexibility
K. Harmrolfs, S. Werner, Helmholtz Centre for Infection Research (HZI), Saarbrücken/D; A. Bauer, M. Brönstrup, C. Lattemann, Sanofi-Aventis Deutschland GmbH, Frankfurt/D; R. Müller, Helmholtz Centre for Infection Research (HZI), Saarbrücken/D
C 05 Anthoceros agrestis: A hornwort that produces rosmarinic acid and other caffeic acid derivatives
S. Pezeshki, M. Petersen, University of Marburg/D
C 06 In vitro reconstruction of polyketide biosynthetic pathways - Towards a chemoenzymatic total synthesis the jerangolids
S. Friedrich, F. Hahn, Leibniz Universität Hannover/D
C 07 Stereoselectivity of isolated dehydratase domains of borrelidin polyketide synthase and their contribution to cis-double bond formation
N. Kandziora, F. Hahn, Leibniz Universität Hannover/D; J. Andexer, University of Freiburg/D; P. Leadlay, University of Cambridge/UK
C 08 In vitro studies on the biosynthesis of the eastern fragment of ambruticin
G. Berkhan, Leibniz Universität Hannover/D; C. Holec, University of Düsseldorf/D; F. Hahn, Leibniz Universität Hannover/D
C 09 Optimization of the precursor supply for the improved production of tacrolimus in Streptomyces tsukubaensis
S. Kocadinc, W. Wohlleben, A. Bera, University of Tübingen/D
C 10 Biosynthesis of lysolipin: Microbial communication or active defense?
S. Rohrer, P. Lopez, T. Weber, W. Wohlleben, University of Tübingen/D
C 11 Screening cyanobacteria from the Portuguese cost for anticancer activity
M. Costa, S.R. Costa, M.J. Ribeiro, P.N. Leão, A. Barreiro, Porto University/P; P. Barros, Polytechnic Institute of Porto, Vila Nova de Gaia/P; M. Garcia, J. Costa-Rodrigues, M.H. Fernandes, V. Vasconcelos, R. Martins, Porto University/P
C 12 Reprogramming of non-colinear modular polyketide synthases
Y. Sugimoto, B. Busch, L. Ding, N. Traitcheva, J. He, K. Ishida, C. Hertweck, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena/D
C 13 The biosynthesis of pyrroindomycin B requires PyrD4 an α/β hydrolase with associated Diels-alderase activity
E.P. Patallo, M. Gruner, TU Dresden/D; A.F. Brana, University of Oviedo/E; K.H. Van Pée, TU Dresden/D
C 14 Production of new bioactive compounds by plants and bacteria using new and improved halogenases
D. Milbredt, K.-H. van Pée, TU Dresden/D
C 15 The flavin-dependent phenylpyrrole halogenase PrnC from pyrrolnitrin biosynthesis - Purification and characterisation
A. Adam, K.-H. van Pée, TU Dresden/D
C 16 Chem-Bio-Chem cascade synthesis of erythromycin derivatives
N. Pryk, S. Klopries, U. Sundermann, F. Schulz, TU Dortmund/D
C 17 Contributions to the elucidation of pentachloropseudilin biosynthesis in Actinoplanes sp. ATCC 33002
V. Weichold, K.-H. van Pée, TU Dresden/D
C 18 Enhancing production of antitumor mithramycins in Streptomyces argillaceus by metabolic engineering
D. Zabala, A.F. Braña, A.B. Flórez, J.A. Salas, C. Méndez, University of Oviedo/E
C 19 Architecture of acyltrasferase (AT) machinery in trans-AT polyketide synthases
M. Till, P.R. Race, University of Bristol/UK
C 20 A straightforward synthesis of new pretubulysin-derivatives containing a photolabile protecting group via Ugi-reaction
J. Hoffmann, U. Kazmaier, Saarland University, Saarbrücken/D
C 21 "Glycosylation Switching": In vivo glycosylation of bioactive natural products regulates their mode-of-action
M. Ueda, Tohoku University, Sendai/J
C 22 New dioxolanone moiety containing secondary metabolites from the grape black rot fungus Guignardia bidwellii
I. Buckel, University of Mainz/D; D. Molitor, Centre de Recherche Public - Gabriel Lippmann, Belvaux/L; J.C. Liermann, L.P. Sandjo, University of Mainz/D; B. Berkelmann-Löhnertz, Hochschule Geisenheim University/D; T. Opatz, E. Thines, University of Mainz/D
C 23 Transposon mutagenesis of Streptomyces rapamycinicus to elucidate the interaction with the fungus Aspergillus nidulans
T. Netzker, V. Schroeckh, A.A. Brakhage, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D
C 24 Analysis of the biosynthesis of chlorinated pyrrole moieties from Aster tataricus, Penicillium islandicum and Streptomyces albogriseolus
L. Flor, TU Dresden/D; T. Weber, University of Tübingen/D; J. Kalinowski, University of Bielefeld/D; K.-H. van Pée, TU Dresden/D
C 25 Target identification with natural products based substances - A pharmaceutical perspective
D. Hoepfner, P. Krastel, F. Petersen, E. Schmitt, Novartis Pharma AG, Basel/CH
C 26 Total synthesis of (±)-trichodiene
A volatile marker for trichothecene biosynthesis

J. Gebauer, C. Wedler, H. Schick, ASCA GmbH, Berlin/D; M. Koch, BAM, Berlin/D
C 27 Hypoxylon rickii - A multiproducer of bioactive secondary metabolites
E. Kuhnert, F. Surup, M. Stadler, Helmholtz Centre for Infection Research, Braunschweig/D
C 28 Mevalonolactone isotopologues for structure elucidation of terpenoids via CLSA-NMR-technique
L. Barra, J.S. Dickschat, TU Braunschweig/D
C 29 Biocatalyst and process development for the fermentative synthesis of monoterpene-derived natural products
C. Willrodt, C. David, B. Bühler, M.K. Julsing, A. Schmid, TU Dortmund/D
C 30 Studies towards stereoselective syntheses of lipoxin B4 analogs
A. Nava, University of Mainz/D
C 31 Stereoselective synthesis of elaeocarpine
C. Heescher, University of Mainz/D
C 32 A novel approach towards equisetin analog syntheses
L. Hoffmann, University of Mainz/D
C 33 Determination of the absolute configuration of biologically active natural products by VCD spectroscopy
L. Andernach, I. Buckel, University of Mainz/D; P.H. Rieger, IBWF Kaiserslautern/D; E. Thines, T. Opatz, University of Mainz/D
C 34 Synthesis of polyhydroxylated indolizidine alkaloids and analogs
F. Bohland, University of Mainz/D
C 35 Iron- and haem-binding properties of the sensory protein HbpS from Streptomycetes
I. Wedderhoff, University of Osnabrück/D; A.E. Torda, Hamburg University/D; H. Schrempf, D. Ortiz de Orué Lucana, University of Osnabrück/D
C 36 Ultra-high throughput microbiology: redefining the screening capabilities for natural products from Actinobacteria using microfluidic culture droplets
M. Tovar, E. Zang, K. Martin, T. Weber, Leibniz Institute for Natural Product Research (HKI), Jena/D; T. Henkel, Institute of Photonic Technology (IPHT), Jena/D; M. Roth, Leibniz Institute for Natural Product Research (HKI), Jena/D
C 37 Environmentally desirable synthesis of natural products without use of organic solvent at room temperature
H. Dokari, M. Hammadi, B. Hamada, University M'hamed Bougara of Boumerdes/DZ
C 38 Impact of prebiotics on bile acid induced colon cancer
B. Afolabi, S. Appiah, P. Azra, L. Ghali, Middlesex University, London/UK
C 39 Microliter-scale synthesis of megasynthases
N. Cortina, University of Frankfurt/D
C 40 Intercallated metal phthalocyanine: Multistep electron transfert oxidations
N. Benferrah, M. Hammadi, H. Dokari, N. Ouslimani, University M'hamed Bougara of Boumerdes/DZ
C 41 Mensacarcin biosynthesis and the role of MsnO8 in epoxide formation
S. Maier, T. Pflüger, S.L. Andrade, University of Freiburg/D; T. Paululat, University of Siegen/D; A. Bechthold, University of Freiburg/D
C 42 Studies on the biosynthesis of gabaculine
S. Haßler, V. Brecht, S. Ferlaino, M. Müller, University of Freiburg/D
C 43 Chemical communication between endophytic fungi and the plant microbiome: From molecular mechanisms to bioactive compounds
M. Vallet, S. Amand, A. Combès, B. Nay, S. Prado, Muséum National d'Histoire Naturelle, Paris/F
C 44 XptB from Aspergillus nidulans is an O-prenyltransferase for xanthones
D. Pockrandt, University of Marburg/D
C 45 Pipeline for ab initio NMR spectra simulation
L. de Figueiredo, European Bioinformatics Institute, Cambridge/UK; A.R. Allouche, Université Lyon 1, Villeurbanne/F; A.M. Castillo, Universidad Nacional de Colombia, Bogotá D.C./CO; J. Wist, Universidad del Valle, Cali/CO; L. Patiny, Ecole Polytechnique Fédérale de Lausanne/CH; C. Steinbeck, European Bioinformatics Institute, Cambridge/UK
C 46 The role of Streptomyces prodiginines to suppress the fungus Verticillium dahliae
H. Meschke, H. Schrempf, University of Osnabrück/D
C 47 Astin and cyclochlorotine - Two similar non-ribosomal peptides from unrelated organisms
T. Schafhauser, A. Kulik, T. Weber, W. Wohlleben, University of Tübingen/D
C 48 Imidacins - Novel secondary metabolites from the myxobacterium Stigmatella aurantiaca identified by total synthesis
M. Kostka, TU Braunschweig/D; D. Krug, Saarland University, Saarbrücken/D; R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D; S. Schulz, TU Braunschweig/D
C 49 New pyrroloquinoline alkaloids from Mycena pelianthina
A. Pulte, University of Bremen/D; S. Peters, TU München, Garching/D; P. Spiteller, University of Bremen/D
C 50 Discovery and characterization of a trans-3/4-proline hydroxylase in the putative pneumocandin biosynthesis cluster of Glarea lozoyensis
S. Houwaart, W. Hüttel, University of Freiburg/D
C 51 Identification of the 20S proteasome as a functional target of pretubulysin, a microtubule-destabilizing agent
B. Mönch, University of Jena/D; A. Ullrich, J. Burkhart, U. Kazmaier, Saarland University, Saarbrücken/D; N. Wielsch, A. Svatos, Max Planck Institute for Chemical Ecology, Jena/D; C. Pergola, O. Werz, University of Jena/D
C 52 Secondary metabolites of Streptomyces collinus Tü 365
D. Iftime, A. Kulik, T. Weber, W. Wohlleben, University of Tübingen/D
C 53 Combinatorial metabolic engineering of microorganisms for the synthesis of plant natural products
P.V. van Summeren-Wesenhagen, M. Bott, J. Marienhagen, Forschungszentrum Jülich GmbH/D
C 54 Reprogramming the nonribosomal code for click amino acids
H. Kries, R. Wachtel, A. Pabst, B. Wanner, D. Hilvert, ETH Zurich/CH
C 55 A subdomain swap strategy for NRPS reengineering
H. Kries, D. Niquille, D. Hilvert, ETH Zurich/CH
C 56 Elucidation of chelocardin biosynthesis in Amycolatopsis sulphurea: Towards a platform for producing atypical tetracycline antibiotic
T. Lukezic, U. Lesnik, A. Podgorsek, B. Jenko, J. Horvat, Acies Bio, Ltd., Ljubljana/SLO; T. Polak, University of Ljubljana/SLO; M. Sala, National Institute of Chemistry, Ljubljana/SLO; P. Herron, I.S. Hunter, University of Strathclyde, Glasgow/UK; G. Kosec, S. Fujs, H. Petkovic, Acies Bio, Ltd., Ljubljana/SLO
C 57 Decipher the biochemistry of gliotoxin biosynthesis
D. Scharf, A. Habel, P. Chankhamjon, T. Heinekamp, A. Brakhage, C. Hertweck, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D
C 58 Synthetic and structure-activity relationship studies on muraymycin nucleoside-peptide antibiotics
C. Ducho, A.P. Spork, M. Büschleb, O. Ries, University of Paderborn/D; G. Mieskes, R. Jahn, Max Planck Institute of Biophysical Chemistry, Göttingen/D
C 59 Novel simocyclinones from Kitasatospora sp.
O. Bilyk, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken/D; T. Paululat, University of Siegen/D; A. Luzhetskyy, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken/D
C 60 The cyanobacterial hepatotoxin microcystin is interfering with major path of carbon in Microcystis aeruginosa
S. Meissner, University of Potsdam/D; J. Fastner, Federal Environmental Agency, Berlin/D; D. Steinhäuser, Max Planck Institute of Molecular Plant Physiology, Potsdam/D; E. Dittmann, University of Potsdam/D
C 61 Scaffolding platform for expression of cytochrome P450 enzymes
U. Christensen, S. Seppälä, M.T. Nielsen, K.M. Madsen, J. Andersen-Ranberg, B. Hamberger, B. Lindberg-Møller, M.H.H. Nørholm, TU of Denmark (DTU), Hørsholm/DK
C 62 Vinylogous carbon chain cranching catalyzed by a dedicated polyketide synthase module
T. Bretschneider, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D; J. Heim, University of Tübingen/D; D. Heine, B. Busch, R. Winkler, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D; G. Zocher, University of Tübingen/D; T. Stehle, University of Tübingen, Jena/D and University School of Medicine, Nashville, TN/D; C. Hertweck, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D
C 63 Chartreusin-gilvocarcin-hybrids
N. Ueberschaar, Z. Xu, K. Scherlach, M. Metsä-Ketelä, T. Bretschneider, H.-M. Dahse, C. Hertweck, Leibniz Institute for Natural Product Research and Infection Biology e.V. - Hans-Knöll-Institute, Jena/D
C 64 Rapid aging of a complex polyketide with impact on quorum sensing
K. Ishida, T. Lincke, C. Hertweck, Leibniz Institute for Natural Product Research and Infection Biology, Jena/D
C 65 Total synthesis and biological evaluations of an aplyronine A-mycalolide B hybrid
K. Kobayashi, H. Kogen, Meiji Pharmaceutical University, Tokyo/J; I. Hayakawa, H. Kigoshi, University of Tsukuba/J
C 66 Bioproduction of prostaglandins in recombinant E. coli cells
J. Guder, M. Buchhaupt, J. Schrader, DECHEMA Research Institute, Frankfurt/D
C 68 Phenylphenalenone-type compounds and its role as phytoalexins in the pathosystem Musa - M. fijiensis
W. Hidalgo Bucheli, M. Reichelt, B. Schneider, Max Planck Institute for Chemical Ecology, Jena/D
C 69 Artificial multi-gene expression systems for natural product formation and its deployment -in vivo or in vitro
G. Zipf, ATG:biosynthetics, Merzhausen/D; J. Maier, IStLS, Boll/D; H. Bernauer, ATG:biosynthetics, Merzhausen/D; G. Schmidt, ATG:biosynthetics, Boll/D
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