10th Status Seminar Chemical Biology


Tuesday, 20 January 2015

12:50 Keynote Lecture
Towards a chemical probe set targeting the human bromodomain family
S. Knapp, University of Oxford/UK
13:30 Unravelling the alternative RNA splicing labyrinth with chemical biological tools
G. Burley, University of Strathclyde, Glasgow/UK
13:50 Regulation of the transcription cycle by Cyclin-dependent kinases
A.K. Greifenberg, C.A. Bösken, D. Hönig, K. Anand, M. Geyer, University of Bonn/D
14:10 Specific antidotes for dabigatran: structure-guided affinity optimisation and functional characterisation
H. Nar, Boehringer Ingelheim Pharma GmbH & Co. KG/D
14:30 Coffee break
14:50 Developing antagonists for the MET-HGF/SF protein-protein interaction using a fragment-based approach
A. Winter, University of Leicester/UK; A. Sigurðardóttir, D. DiCara, MRC Laboratory of Molecular Biology, Cambridge/UK; G. Valenti, Max Delbrück Center, Berlin/D; T.L. Blundell, The University of Cambridge/UK; E. Gherardi, MRC Laboratory of Molecular Biology, Cambridge/UK
15:10 Selective Sirt2-inhibition by ligand-induced rearrangement of the active site
T. Rumpf, M. Schiedel, University of Freiburg/D; B. Karaman, C. Roessler, University of Halle-Wittenberg/D; B.J. North, Harvard Medical School, Boston, MA/USA; A. Lehotzky, Hungarian Academy of Sciences, Budapest/H; M. Pannek, C. Steegborn, University of Bayreuth/D; D.A. Sinclair, Harvard Medical School, Boston, MA/USA; S. Gerhardt, University of Freiburg/D; J. Ovádi, Hungarian Academy of Sciences, Budapest/H; M. Schutkowski, W. Sippl, University of Halle-Wittenberg/D; O. Einsle, M. Jung, University of Freiburg/D
15:30 Prediction of peptide binding modes using small molecule docking programs
B. Windshügel, Fraunhofer IME, Hamburg/D
15:50 Keynote Lecture
How to kill a mocking bug - structural insights into Tc toxin complex action

S. Raunser, Max-Planck-Institut für molekulare Physiologie, Dortmund/D
16:30 Coffee break
16:50 Lectures of selected posters

P 06
Towards the discovery of a selective EPHA2 inhibitor
S. Heinzlmeir, G. Medard, University of Munich, Freising/D; K. Saxena, H. Schwalbe, University of Frankfurt/D; B. Kuster, University of Munich, Freising/D

  P 09
Wnt signaling inhibition by withanolide-inspired small molecules:β-catenin on a rollercoaster ride
S. Kapoor, M. Sheremet, S. Sievers, S. Ziegler, K. Kumar, H. Waldmann, Max Planck Institute of Molecular Physiology, Dortmund/D

P 12
Novel, highly selective benzoxazepine-type inhibitors for the CREBBP/EP300 bromodomains
F. Bracher, T.A. Popp, University of Munich/D; O. Fedorov, C. Tallant, S. Knapp, SGC Oxford/UK


P 13
Natural product inspired compound collection emphasizes the MAP4K4 connection to neuritogenesis
P. Schröder, T. Förster, S. Ziegler, K. Kumar, H. Waldmann, Max Planck Institute of Molecular Physiology, Dortmund/D


P 14
Distinct signaling requirements for the establishment of naïve pluripotency in chemical reprogramming of late-stage epiblast stem cells
D.J. Illich, M. Zhang, Max Planck Institute for Molecular Biomedicine, Münster/D; A. Ursu, Max Planck Institute of Molecular Physiology, Dortmund/D; R. Osorno, G. Wu, D. Esch, K. Adachi, D. Sabour, M. Stehling, S. Höing, Max Planck Institute for Molecular Biomedicine, Münster/D; S. Ziegler, H. Waldmann, Max Planck Institute of Molecular Physiology, Dortmund/D; H.R. Schöler, Max Planck Institute for Molecular Biomedicine, Münster/D


P 15
Multivalent DOTAM derivatives for bacteria theranostic applications
H.-Y. Hu, B. Rais, N. Meier, G. Sergeev, P. P. Müller, M. Brönstrup, Helmholtz Center for Infection Research, Braunschweig/D


P 17
Transition-metal-mediated uncaging in living human cells - an emerging alternative to photolabile protecting groups
T. Völker, E. Meggers, Universität Marburg/D


P 19
Multivalent peptide-conjugates to address viral interactions
M. Glanz, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin/D; D. Lauster, Humboldt-Universität zu Berlin/D; M. Hellmund, K. Ludwig, C. Böttcher, R. Haag, FU Berlin/D; A. Herrmann, Humboldt- Universität zu Berlin/D; C.P.R. Hackenberger, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin/D

17:20 Keynote Lecture
Chemical glycobiology enabled by automated glycan synthesis
P.H. Seeberger, Max Planck Institute of Colloids and Interfaces, Berlin/D
Postersession & Get together


Wednesday, 21 January 2015

08:40 Keynote Lecture
Peptide antibiotics in bacterial host pathogen interactions
R. Süßmuth, TU Berlin/D
09:20 The chemistry and biology of Englerin A
S. Hahn, T. Seitz, L. Radtke, M. Willot, M. Christmann, FU Berlin/D
09:40 Marine alkaloids and analogues are synthesized in very concise sequentially Pd-catalyzed processes in a one-pot fashion
T.J.J. Müller, University of Düsseldorf/D
10:00 Small molecule modulators of histone-modifying enzymes
A. Ganesan, University of East Anglia, Norwich/UK
10:20 Coffee break
10:40 How best to discover bioactive chemotypes?
A. Nelson, University of Leeds/UK
11:00 A rationally designed modular construction kit for small-molecule inhibitors of protein-protein interactions involving proline-rich motifs
H.-G. Schmalz, University of Köln/D; R. Kühne, Leibniz Institute for Molecular Pharmacology, Berlin/D



The structure of CotB2 a bacterial diterpene cyclase is reported. Plasticity residues have been mutated resulting in new, bioactive products
R. Janke, FU Berlin/D; C. Görner, M. Hirte, T. Brück, TU München, Garching/D; B. Loll, FU Berlin/D
11:40 Keynote Lecture
Enrichung chemical space to drug undruggable targets
D. Spring, University of Cambridge/UK
12:20 Lunch break
13:20 Macrocycles in medicinal chemistry: strategies and synthetic approaches
F. Giordanetto, Taros Chemicals GmbH & Co. KG, Dortmund/D



Generic cell-permeable probes of eukaryotic and bacterial sialyl transferases: new targets in inflammation and cancer?
J.J. Preidl, University of Berlin/D; V.S. Gnanapragassam, R. Horsttkorte, University of Halle-Wittenberg/D; J. Rademann, University of Berlin/D
14:00 Unravelling the structure of amyloid fibrils
L.C. Serpell, University of Sussex, Brighton/UK
14:20 Keynote Lecture
Two adventures in chemical biology - Palladium mediated cellular chemistry and in vivo optical medical imaging
M. Bradley, University of Edinburgh/UK
15:00 Coffee break
15:20 Synthetic polymers and biological responses
P. Magennis, S. Spain, J. Magnusson, G. Sicilia, L. Sasso, G. Mantovani, K. Winzer, C. Alexander, University of Nottingham/UK
15:40 Gel forming biomaterials based on short peptides
H. Eickhoff, U. Wank, L. Schindler, K.-H. Wiesmüller, EMC microcollections GmbH, Tübingen/D
16:00 Keynote Lecture
Programming supramolecular biomaterials for biomedical applications
T. Weil, University of Ulm/D
16:40 Closing
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