From the inventory of a cell by –omics to synthetic biology, from strain development to industrial biotechnological processes including downstream processing
KMUs aus z.B. den Bereichen der Agrar- / Forstwirtschaft und der chemischen Industrie, sollen über ein im Rahmen des Projekts zu entwickelndes Multikriterien-Systems Hilfestellung für Entwicklungs- und Investitionsentscheidungen erhalten. Auch Wissenschaftler sollen durch das Tool bei der Ausrichtung ihrer Forschungs- und Entwicklungsprojekte unterstützt werden können. Das in EvaChem zu entwickelnde Werkzeug soll sich von bestehenden Werkzeugen dadurch unterscheiden, dass es gegenüber bereits existierenden, komplexen Methoden - die meist nur durch Experten und mit einem hohen Aufwand durchgeführt werden können - leicht in der Praxis anwendbar ist aber gleichzeitig eine im Vergleich zu bekannten, vereinfachten Methoden deutlich höhere Aussagekraft besitzt.
For more information please visit https://foodbiotech.uni-hohenheim.de/ .
2. revised edition
The Escherichia coli model process described in the recommendation also makes it possible to characterise the biological performance of a system. The standardised process aims to determine the performance of bioreactors, in particular single-use bioreactors, and to evaluate their suitability for microbial applications. Since microbial processes place high demands on the bioreactor system with regard to oxygen transfer, this is of particular importance; another important parameter is heat removal.
The associated Excel tool offers the possibility of a standardised evaluation, so that a comparison across bioreactor systems is possible. Calculations, e.g. of the volumetric mass transfer coefficient, will be performed automatically after input of the raw data.
Recommendation and Excel tool were developed by the "Single-Use Microbial" working group of DECHEMA's expert group "Single-Use Technology in Biopharmaceutical Manufacturing".
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