Enzymes for Industrial Applications 2020


Conference Programme

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TUESDAY, 4 February 2020
10:00 Check-in and opening of exhibition
  Moderation: Dr. Emil Byström, CEO, SpinChem, Umea/Sweden
11:00 Opening
Dr. Kathrin Rübberdt
, Head of Biotechnology
DECHEMA e.V., Frankfurt/Germany
11:05 Welcome address
Dr. Carsten Ott
, Head of Technology & Innovation
Hessen Trade & Invest GmbH, Wiesbaden/Germany
Session 1: Process development
11:15 Development of an in situ-product crystallization (ISPC) concept to shift the reaction Equilibria of selected transaminase-catalyzed reactions
  • Development of screening procedure for suitable counter ions
  • Combination of ISPC with transaminase reaction
  • Application example for API-intermediate
Dr. Philipp Süss, Group Leader Biocatalysis and Chemical Synthesis
Enzymicals, Greifswald/Germany


Developing and scaling up laboratory processes of (1S,3R)-3-Acetamidocyclohexane-1-carboxylic Acid

  • Novozym 435 Mediated Acetylation for the Preparation of key building block
  • Using Spinchem® RBR Technology for Immobilized Enzymatic Reactions
  • A Comparative Study with Traditional Batch Synthesis

Dr. Subhash Pithani, Senior Research Scientist, LSC Medicinal Chemistry AstraZeneca R&D, Gothenburg/Sweden


Membrane assisted process intensification for enzymatic production of chiral amines, esters and oligosaccharides

  • Process intensification plays an important role in the industrial application of enzymatic processes
  • Results of membrane assisted enzymatic synthesis for three selected products
  • Example products: chiral amines, esters and oligosaccharides

Dr. Yamini Satyawali, R&D, Bioprocess development
Flemish Institute for Technological Research (VITO), Mol/Belgium

12:45 Exhibitor Pitches
13:00 Lunch break, interactive networking and discussion @ "topic tables" in exhibition area
Session 2: Industrial processes
14:15 Cell-free synthetic biology for the production of functional ingredients
  • Multi-enzyme cascase reactions to make high-value products
  • In vivo versus in vitro approaches
  • Enzyme engineering as key enabling technology

Dr. Marc Struhalla, CEO
c-LEcta, Leipzig/Germany

14:45 Efficient and safe biocatalytic processes to oxyfunctionalised products using hydratases and biooxidations with water and oxygen as reactants
  • Enzymes are valuable biocatalysts especially because of their chemo-, regio- and enantioselectivity
  • Oxygen can be used in a safe way with organic compounds by thorough selection of reagents, solvents and reaction conditions
  • Water additions by hydratase enzymes is an under-represented but promising strategy to produce secondary and tertiary alcohols
Dr. Martin Schürmann, Principal Scientist Biocatalysis
InnoSyn, Geleen/The Netherlands


What can a new CRO offer to the biotech industry?

  • Digging into the repertoire of oxidoreductases and other known but forgotten enzymes
  • Experimental validation of computational predictions
  • Enzyme stabilization and improvement

Dr. Nikola Loncar, CEO
Gecco Biotech, Groningen/The Netherlands

15:45 Exhibitor Pitches
16:00 Coffee break, interactive networking and discussion @ "topic tables" in exhibition area
Start-Up Session
 17:15 Enzyme engineering made easier
  • A brief description of Zymvol Biomodeling

  • Computational enzyme discovery and design

  • Achievements and challenges faced in the last 2 years

Dr. Maria F. Lucas, Managing Director
ZYMVOL, Barcelona/Spain

17:35 Scaling of biopolymer synthesis − requirements vs. costs
  • Identification & elimination of cost drivers in upstream and downstream processes
  • Early stage process development in a vague requirements environment
  • Building block systems − an option for required flexibility or a money burner?

Dr. Konstantinos Antonopoulos, Co-Founder & CEO
mk2 Biotechnologies, Munich/Germany


Enzyme cascades - Industrial processes inspired by nature

  • Versatility for process development
  • Improved downstream performance
  • Reduced side products

André Pick, CEO and Founder
CASCAT, Straubing/Germany

18:15 Discussion @ "topic tables" in exhibition area
19:00 Networking dinner at Senckenberg Natural History Museum
23:00 End of first PRAXISforum day


WednesDAY, 5 February 2020
08:30 Re-opening of exhibition
Session 4: Enzyme immobilization


Carrier-bound immobilized enzymes

  • Why immobilize an enzyme?
  • How to immobilize an enzyme
  • Immobilized enzymes in various applications

Dr. Rob Schoevaart, Managing Director
ChiralVision, Leiden/The Netherlands


Using green chemistry efficiently

  • Utilising enzymes efficiently is the key challenge to enable their use in industrial applications
  • Efficient immobilisation of enzymes and uses them in packed bed reactors
  • The technology has been demonstrated at industrial relevant scales

Dr. Elin Stridfeldt, Lead Researcher
EnginZyme, Solna/Sweden


Applications of immobilized enzymes in pharma, chemical and food industry

  • Key applications of immobilized enzymes in industry
  • Applications discussed by type of reactor used, type of media used
  • More than 50 different interesting applications

Dr. Alessandra Basso, Business Development Manager Life Sciences
Purolite, South Wales/Great Britain

10:30 Coffee break, interactive networking and discussion @ "topic tables" in exhibition area
SESSION 5: Enzymes 4.0 − Modelling, Simulation and ENGIneering


Next generation enzyme discovery AI based identification and optimization of enzyme candidates using 3D point-cloud CatalophoresTM

  • In-silico enzyme discovery
  • Computational enzyme design and optimisation
  • Machine learning based structural bioinformatics

Dr. Christian Gruber, CEO
Innophore, Graz/Austria


From computer aided enzyme engineering to biocatalytic manufacturing at scale

  • Benefits of biocatalysis
  • Computer guided enzyme evolution
  • Examples of biocatalytic processes at scale

Dr. Grzegorz Kubik, Business Development Manager
Enzymaster Deutschland, Düsseldorf/Germany


Engineering enzyme cascades for highly efficient pharmaceutical manufacturing

  • Utilized Codexis proprietory protein engineering technology
  • Optimized the activity, stability, and specificity of enzymes under process conditions
  • The multi-enzyme cascade generated the single desired product in high overall yield

Dr. Margie Borra-Garske, Senior Scientist
Codexis, Redwood City/USA

13:15 Lunch, interactive networking and discussion @ "topic tables" in exhibition area
14:30 End of PRAXISforum

*Programme subject to change

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