1st European Conference on Natural Products

Oral Programme


Sunday, 22 September 2013
17:00  Registration and Welcome Reception (to 19:00)
  Monday, 23 September 2013
09:30 Opening Session

K. Wagemann, DECHEMA e.V., Frankfurt/D
R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken/D and Helmholtz Centre for Infection Research, Saarbrücken/D
E. Dittmann,
Universität Potsdam/D and VAAM e.V., Frankfurt/D

  Exploiting Plant Natural Products
  Chairs: D. Ober, University of Kiel/D,
S. O'Connor, The John Innes Centre, Norwich/UK
09:45 Keynote Lecture
Molecular breeding of medicinal crops and discoveries along the way
I. Graham, University of York/UK
10:30 Transport of plant natural products
B.A. Halkier, University of Copenhagen/DK
11:00 Coffee Break
11:30 Benzylisoquinoline alkaloid biosynthesis - a brave new world built on a century of discovery
P. Facchini, University of Calgary/CND

The plant cell is a smart green cell factory
K.-M. Oksman-Caldentey, M. Nees, A. Ritala, S. Häkkinen, L. Nohynek, H. Rischer, VTT Technical Research Centre of Finland, Espoo/FIN

  Poster Presentations

Poster A 12
A phenotypic screening toolbox permits the identification of novel compounds with anti-cancer properties derived from marine fungi

B. Ellinger, European ScreeningPort GmbH, Hamburg/D; J. Landskron, Biotechnology Centre of Oslo/N; A. Prashar, Hypha Discovery Ltd., Uxbridge/UK; J. Silber, Kieler Wirkstoff-Zentrum am Helmholtz-Zentrum für Ozeanforschung (GEOMAR)/D; S. Wrigley, Hypha Discovery Ltd., Uxbridge/UK; K. Tasken, Biotechnology Centre of Oslo/N; A. Labes, Kieler Wirkstoff-Zentrum am Helmholtz-Zentrum für Ozeanforschung (GEOMAR)/D; P. Gribbon, European Screeningport GmbH, Hamburg/D


Poster A 52
Application of undifferentiated plant cells for the reliable large scale production of natural substances

D. Ullisch, M. Pump, K. Schütte, G. Gorr, Phyton Biotech GmbH, Ahrensburg/D


Poster A 60
2-Acylcyclohexane-1,3-diones from Peperomia trineura and P. alata

E.A. Ferreira, J.B. Reigada, Universidade de São Paulo/BR; M.C.M. Young, Instituto de Botânica, São Paulo/BR; E.F. Guimarães, Instituto de Pesquisa Jardim Botânico, Rio de Janeiro/BR; G.C. Franchi Junior, A.E. Nowill, Universidade de Campinas/BR; J.H.L. Lago, Universidade Federal de São Paulo, Diadema/BR; M.J. Kato, Universidade de São Paulo/BR

13:00 Lunch
14:00 Postersession A
  Genome Mining and Biodiversity
  Chairs: M. Stadler, Helmholtz Centre for Infection Research, Braunschweig/D; 
J.A. Salas, University of Ovieto/E
15:00 Chemodiversity and chemiconsistency in Penicillium, Aspergillus and Talaromyces
J.C. Frisvad, Technical University of Denmark, Lyngby/DK
15:30 Discovery new bioactive metabolites by high quality screening of actinomycetes
S. Donadio, KtedoGen/NAICONS, Milano/I
16:00 Activation of silent gene clusters for natural products in actinomycet
J.A. Salas, University of Ovieto/E
16:30 Coffee Break
17:00 Second version of versatile Streptomyces host for heterologous expression of biosynthetic gene(s) for secondary metabolites
H. Ikeda, Kitasato University/J

Poster Presentations


Poster A 02
Evolution of secondary metabolite biosynthesis pathways in marine actinomycetes: clues from genome mining

S.B. Zotchev, O.N. Sekurova, Norwegian University of Science and Technology, Trondheim/N


Poster A 20
Genome mining of lasso peptides from Proteobacteria

J. Hegemann, M. Zimmermann, S. Zhu, M. Marahiel, University of Marburg/D


Poster A 03
Genome mining of animal and plant pathogenic fungi for bioactive metabolites

Y.H. Chooi, P.S. Solomon, Australian National University, Acton/AUS; Y. Tang, University of California at Los Angeles, CA/USA

18:00 End of 1st day
19:30 Conference Dinner at the Restaurant "DEPOT 1899" in Frankfurt-Sachsenhausen (to 23:00)

  Tuesday, 24 September 2013
  Chemical and Biological Synthesis
  Chairs: R. Müller, Helmholtz-Institute for Pharmaceutical Research Saarland,  Saarbrücken/D and Helmholtz Centre for Infection Research, Saarbrücken/D;
J.T. Rohr, University of Kentucky, Lexington, KY/USA
09:00 Keynote Lecture
Translating fungal chemical biology into human chemical biology
G.F. Bills, The University of Texas, Houston, TX/USA
09:45 Biofunctional enzymes - key features of biosynthetic pathways to natural product drugs
J.T. Rohr, University of Kentucky, Lexington, KY/USA
10:15 Total-, semi- and mutasynthesis - the trident of natural product synthesis
A. Kirschning, Leibniz Universität Hannover/D
10:45 Coffee Break
11:15 Total synthesis of antibacterial natural products and SAR studies
K.-H. Altmann, ETH Zürich/CH
11:45 Polyketide-terpene natural products from Filamentous fungi: biosynthetic studies on viridicatumtoxin and fumagillin
Y. Tang, Y.H. Chooi, H.-C. Lin, University of California, Los Angeles, CA/USA
  Poster Presentations

Poster B 30
Unique ß-amino acid biosynthetic pathways involved in bacterial macrolactam polyketides biosynthesis

F. Kudo, M. Takaishi, K. Amagai, T. Eguchi, Tokyo Institute of Technology/J


Poster B 42
Synthesis of optically active natural products using chiral building blocks prepared by enzymatic reaction

Y.M. Mizutani, J.N. Nokami, Okayama University of Science/J


Poster B 71
Novel synthetic chain termination probes for the investigation of polyketide biosynthesis in vivo

J.S. Parascandolo, E. Riva, M. Tosin, University of Warwick, Coventry/UK

12:45 Lunch
13:45 Postersession B
  Natural Products - Synthesis, Derivates and Application
  Chairs: M. Brönstrup, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main/D;
F. Bischoff, Boehringer Ingelheim Animal Health GmbH, Ingelheim/D

Efficacy of natural products to reduce the foodborne pathogen, campylobacter in poultry
H. Arambel, D. Donoghue, University of Arkansas/USA

15:15 Cytotoxic conjugates of Disorazol Z with the LHRH receptor agonistic peptide D-Lys6-LHRH as targeted therapy of LHRH-R positive tumors
B. Aicher, T. Schuster, Æterna Zentaris GmbH, Frankfurt am Main/D; A. Schubert, C. Gründker, University Göttingen/D; R. Müller, Helmholtz Centre for Infection Research and Pharmaceutical Biotechnology, Saarbrücken/D; E. Günther, M. Gerlach, M. Teifel, Æterna Zentaris GmbH, Frankfurt am Main/D
15:45 From sugar to antimalarial agent artemisinin
A. Burgard, R. Feling, R. Göller, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main/D
16:15 Coffee Break
  Poster Presentations

Poster B 18
DEM30355/A A novel first in class polyketide from an Amycolatopsis sp.

B. Kepplinger, M. Hall, M. Goodfellow, J. Errington, Newcastle University/UK; N. Allenby, Demuris Ltd., Newcastle upon Tyne/UK


Poster B 69
Nogalamycin biosynthesis - discovery of an unusual monooxygenase

V. Siitonen, B. Blauenburg, P. Kallio, P. Mäntsälä, M. Metsä-Ketelä, University of Turku/FIN


Poster B 03
Pretubulysin - a new option for the treatment of metastatic cancer

R.M. Wiedmann, S. Braig, M. Singer, F. Förster, University of Munich/D; U. Kazmaier,
R. Müller, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D and Helmholtz Centre for Infection Research, Saarbrücken/D; A.M. Vollmar, University of Munich/D

17:15 Get-together with drinks and snacks
18:45 Keynote Lecture
Progress on understanding and engineering biosynthetic enzymes and pathways
A.G. Newman, P.A. Storm, C.R.E. Huitt-Roehl, A.L. Vagstad, R.A. Oliver, R.M. Phelan, C.A. Townsend, Johns Hopkins University, Baltimore, MD/USA
19:30 End of the conference day

  Wednesday, 25 September 2013
  Physiology and Regulation
  Chairs: W. Wohlleben, University of Tübingen/D;
E. Thines, TU Kaiserslautern/D
09:00 Keynote Lecture
Understanding and manipulating antibiotic production in actinomycetes

M. Bibb, John Innes Centre, Norwich/UK

09:45 Unravelling the regulatory networks that control sporulation in Streptomyces
M. Buttner, John Innes Centre, Norwich/UK
10:15 Fungal siderophore metabolism and its role in physiology and virulence
H. Haas/A, Innsbruck Medical University/A
10:45 Coffee Break
11:15 Coordination of secondary metabolism and differentiation in fungi
G. Braus, University of Göttingen/D
11:45 Context dependent antibiotic biosythesis in microorganisms
C. Hertweck, Leibniz Institute for Natural Product Research and Infection Biology, Jena/D

Poster Presentations


Poster C 21
"Glycosylation Switching": In vivo glycosylation of bioactive natural products regulates their mode-of-action

M. Ueda, Tohoku University, Sendai/J


Poster C 35
Iron- and haem-binding properties of the sensory protein HbpS from streptomycetes

I. Wedderhoff, University of Osnabrück/D; A.E. Torda, Hamburg University/D; H. Schrempf, D. Ortiz de Orué Lucana, University of Osnabrück/D


Poster C 18
Enhancing production of antitumor mithramycins in Streptomyces argillaceus by metabolic engineering

D. Zabala, A.F. Braña, A.B. Flórez, J.A. Salas, C. Méndez, University of Oviedo/E

12:45 Lunch
13:45 Postersession C
  Natural Functions of Secondary Metabolites
  Chairs: A. Brakhage, Hans-Knöll-Institut Jena/D;
J. Piel, ETH Zurich/CH
14:45 Keynote Lecture
New ways to exploit natural products for sustainable pest management
J.A. Pickett, Rothamstead Research, Harpenden/UK
15:30 Biosynthesis with a twist - Polytheonamides isolated from the sponge Theonella swinhoei
M. Freeman, ETH Zurich/CH
16:00 Chemical communication in marine plankton
G. Pohnert, University of Jena/D
16:30 Coffee Break
17:00 Natural products from entomopathogenic bacteria
H.B. Bode, University of Frankfurt/D

Poster Presentations


Poster C 23
Transposon mutagenesis of Streptomyces rapamycinicus to elucidate the interaction with the fungus Aspergillus nidulans

T. Netzker, V. Schroeckh, A.A. Brakhage, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena/D


Poster C 60
The cyanobacterial hepatotoxin microcystin is interfering with major path of carbon in Microcystis aeruginosa

S. Meissner, University of Potsdam/D; J. Fastner, Federal Environmental Agency, Berlin/D; D. Steinhäuser, Max Planck Institute of Molecular Plant Physiology, Potsdam/D; E. Dittmann, University of Potsdam/D


Poster C 46
The role of Streptomyces prodiginines to suppress the fungus Verticillium dahliae

H. Meschke, H. Schrempf, University of Osnabrück/D

18:00 End of the conference


 (Programme subject to change)


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Andrea Köhl
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