12:50 | Keynote Lecture Towards a chemical probe set targeting the human bromodomain family S. Knapp, University of Oxford/UK |
13:30 | Unravelling the alternative RNA splicing labyrinth with chemical biological tools G. Burley, University of Strathclyde, Glasgow/UK |
13:50 | Regulation of the transcription cycle by Cyclin-dependent kinases A.K. Greifenberg, C.A. Bösken, D. Hönig, K. Anand, M. Geyer, University of Bonn/D |
14:10 | Specific antidotes for dabigatran: structure-guided affinity optimisation and functional characterisation H. Nar, Boehringer Ingelheim Pharma GmbH & Co. KG/D |
14:30 | Coffee break |
14:50 | Developing antagonists for the MET-HGF/SF protein-protein interaction using a fragment-based approach A. Winter, University of Leicester/UK; A. Sigurðardóttir, D. DiCara, MRC Laboratory of Molecular Biology, Cambridge/UK; G. Valenti, Max Delbrück Center, Berlin/D; T.L. Blundell, The University of Cambridge/UK; E. Gherardi, MRC Laboratory of Molecular Biology, Cambridge/UK |
15:10 | Selective Sirt2-inhibition by ligand-induced rearrangement of the active site T. Rumpf, M. Schiedel, University of Freiburg/D; B. Karaman, C. Roessler, University of Halle-Wittenberg/D; B.J. North, Harvard Medical School, Boston, MA/USA; A. Lehotzky, Hungarian Academy of Sciences, Budapest/H; M. Pannek, C. Steegborn, University of Bayreuth/D; D.A. Sinclair, Harvard Medical School, Boston, MA/USA; S. Gerhardt, University of Freiburg/D; J. Ovádi, Hungarian Academy of Sciences, Budapest/H; M. Schutkowski, W. Sippl, University of Halle-Wittenberg/D; O. Einsle, M. Jung, University of Freiburg/D |
15:30 | Prediction of peptide binding modes using small molecule docking programs B. Windshügel, Fraunhofer IME, Hamburg/D |
15:50 | Keynote Lecture How to kill a mocking bug - structural insights into Tc toxin complex action S. Raunser, Max-Planck-Institut für molekulare Physiologie, Dortmund/D |
16:30 | Coffee break |
16:50 | Lectures of selected posters |
P 06 |
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P 09 Wnt signaling inhibition by withanolide-inspired small molecules:β-catenin on a rollercoaster ride S. Kapoor, M. Sheremet, S. Sievers, S. Ziegler, K. Kumar, H. Waldmann, Max Planck Institute of Molecular Physiology, Dortmund/D |
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P 12 |
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P 13 |
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P 14 |
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P 15 |
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P 17 |
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P 19 |
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17:20 | Keynote Lecture Chemical glycobiology enabled by automated glycan synthesis P.H. Seeberger, Max Planck Institute of Colloids and Interfaces, Berlin/D |
18:00- 21:00 |
Postersession & Get together |
08:40 | Keynote Lecture Peptide antibiotics in bacterial host pathogen interactions R. Süßmuth, TU Berlin/D |
09:20 | The chemistry and biology of Englerin A S. Hahn, T. Seitz, L. Radtke, M. Willot, M. Christmann, FU Berlin/D |
09:40 | Marine alkaloids and analogues are synthesized in very concise sequentially Pd-catalyzed processes in a one-pot fashion T.J.J. Müller, University of Düsseldorf/D |
10:00 | Small molecule modulators of histone-modifying enzymes A. Ganesan, University of East Anglia, Norwich/UK |
10:20 | Coffee break |
10:40 | How best to discover bioactive chemotypes? A. Nelson, University of Leeds/UK |
11:00 | A rationally designed modular construction kit for small-molecule inhibitors of protein-protein interactions involving proline-rich motifs H.-G. Schmalz, University of Köln/D; R. Kühne, Leibniz Institute for Molecular Pharmacology, Berlin/D |
11:20 NEW |
The structure of CotB2 a bacterial diterpene cyclase is reported. Plasticity residues have been mutated resulting in new, bioactive products R. Janke, FU Berlin/D; C. Görner, M. Hirte, T. Brück, TU München, Garching/D; B. Loll, FU Berlin/D |
11:40 | Keynote Lecture Enrichung chemical space to drug undruggable targets D. Spring, University of Cambridge/UK |
12:20 | Lunch break |
13:20 | Macrocycles in medicinal chemistry: strategies and synthetic approaches F. Giordanetto, Taros Chemicals GmbH & Co. KG, Dortmund/D |
13:40 NEW |
Generic cell-permeable probes of eukaryotic and bacterial sialyl transferases: new targets in inflammation and cancer? J.J. Preidl, University of Berlin/D; V.S. Gnanapragassam, R. Horsttkorte, University of Halle-Wittenberg/D; J. Rademann, University of Berlin/D |
14:00 | Unravelling the structure of amyloid fibrils L.C. Serpell, University of Sussex, Brighton/UK |
14:20 | Keynote Lecture Two adventures in chemical biology - Palladium mediated cellular chemistry and in vivo optical medical imaging M. Bradley, University of Edinburgh/UK |
15:00 | Coffee break |
15:20 | Synthetic polymers and biological responses P. Magennis, S. Spain, J. Magnusson, G. Sicilia, L. Sasso, G. Mantovani, K. Winzer, C. Alexander, University of Nottingham/UK |
15:40 | Gel forming biomaterials based on short peptides H. Eickhoff, U. Wank, L. Schindler, K.-H. Wiesmüller, EMC microcollections GmbH, Tübingen/D |
16:00 | Keynote Lecture Programming supramolecular biomaterials for biomedical applications T. Weil, University of Ulm/D |
16:40 | Closing |