8th Status Seminar Chemical Biology

Programme

 

 

Tuesday, January 22, 2013

12:30

Mitgliederversammlung der Fachgemeinschaft Chemische Biologie (nur für Mitglieder)
Screening and compound collections

13:00

KEYNOTE LECTURE
Enabling chemical biology by de novo molecular design

G. Schneider, Swiss Federal Institute of Technology, Zurich/CH
13:40

ACCESS: an academic chemical screening platform for Switzerland
G. Turcatti, École Polytechnique Fédérale de Lausanne (EPFL)/CH

14:00

Small-molecule modulation of 14-3-3 protein-protein Interactions
C. Ottmann, TU Eindhoven/NL

14:20

Who cares for the protons?
P. Czodrowski, Merck KGaA, Darmstadt/D

14:40 Coffee break
15:10 KEYNOTE LECTURE

Drug screening for neglected tropical diseases in an academic environment
R. Brun, University of Basel/CH

15:50

A microscope-based high-throughput screen identifies novel compounds interfering with Notch trafficking/processing
A. Krämer, T. Mentrup, Leibniz Institute for Age Research, Jena/D; B. Kleizen, Utrecht University/NL; E. Rivera-Milla, D. Reichenbach, Leibniz Institute for Age Research, Jena/D; C. Enzensperger, E. Täuscher, H.-D. Arndt, O. Werz, University of Jena/D; C. Englert, A. Ploubidou, C. Kaether, Leibniz Institute for Age Research, Jena/D

16:10

3D Hepatocyte culture to profile compounds
M. Esner, M. Stoeter, A. Janosch, N. Tomschke, M. Bickle, Max Planck Institute of Molecular Biology and Genetics, Dresden/D

16:30 Coffee break
16:50

Poster short presentations

P.02
Design, synthesis and evaluation of TLS DNA polymerase inhibitors
T. Carell, M. Ehrlich, Universität München/D

P.04
Looking for the target: synthesis of peptides found in photorhabdus and xenorhabdus spp

F. Nollmann, H.B. Bode, University of Frankfurt/D

P.09
Probing the signalling complexity of tumor cells by functional screening of peptide and small molecule libraries
C. Schuldt, J. Körner, S. Hallmann, B. Wiedenmann, C. Grötzinger, Charité - Universitätsmedizin Berlin/D

P.12
Archazolid, a novel vacuolar-type ATPase inhibitor, blocks proinflammatory cytokine secretion from human monocytes
O. Scherer, University of Jena/D; R. Müller, Saarland University, Saarbrücken/D; C. Pergola, O. Werz, University of Jena/D

P.22
Development of antibiotic RNA aptamers
K. von Laer, TU Darmstadt/D; G. Mayer, University of Bonn/D; B. Suess, TU Darmstadt/D

P.27
Application of different cryogels for three-dimensional cell culture
A. Baecker, F.J. Gruhl, Karlsruhe Institute of Technology (KIT)/D

17:20 KEYNOTE LECTURE
A new protected open-innovation approach for accelerating translational research
M. Reichman, P.S. Donover, G.C. Prendergast, LIMR Chemical Genomics Center Inc., Wynnewood, PA/USA
18:00 Poster Session
19:00 Buffet
   
  Wednesday, January 23, 2013
Probes and technologies 
 9:00 KEYNOTE LECTURE

Shadowing biological targets by natural product derivatives
K. Gademann, University of Basel/CH

 9:40

Development of a selective PIM1 inhibitor by biophysical tools
T. Neumann, Graffinity Pharmaceuticals GmbH, Heidelberg/D; J-P. Renaud, L. Hijfte, NovAliX, Strasbourg/F

10:00

Capture compound mass spectrometry: chemical biology and molecular modeling on the tracks of membrane protein SAR and novel drug targets
C. Blex, F.G. Quast, J.J. Fischer, A. Marais, S. Michaelis, caprotec bioanalytics GmbH, Berlin/D; A. Diehl, Leibniz-Institut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V.(FMP), Berlin/D; K. Bartho, O.Y. Graebner, A.K. Schrey, M. Sefkow, M. Dreger, H. Koester, F. Kroll, caprotec bioanalytics GmbH, Berlin/D

10:20

Converting peptides into drugs: GPCR ligands for tumor imaging and therapy
S. Bandholtz, A. Klußmeier, J. Körner, Q. Schefer, P. Schulz, B. Wiedenmann, C. Grötzinger, Charité - Universitätsmedizin Berlin/D

10:40 Coffee break
11:00

KEYNOTE LECTURE
Nucleic acid programmed reactions and assemblies for Chemical Biology

O. Seitz, Humboldt Universität zu Berlin/D

11:40

Bicyclic peptide antagonists isolated from phage display libraries
C. Heinis, École Polytechnique Fédérale de Lausanne (EPFL)/CH

12:00

Catalytic alkylation of nucleic acids
D. Gillingham, University of Basel/CH

12:20

KEYNOTE LECTURE
Synthesis of tool compounds for target identification and target validation

R. Breinbauer, Graz University of Technology/A

13:00 Lunch break
13:40 D-A-CH-Förderung in der Grundlagenforschung
G. Bechtold, Deutsche Forschungsgemeinschaft (DFG), Bonn/D
Target identification & MoA
14:00 KEYNOTE LECTURE

Exploiting the protein-fishing approach for target identification of small molecules
O. Werz, University of Jena/D

14:40

Using chemical proteomics to reveal drug targets, drug selectivity, mechanism of action and resistance formation
B. Kuster, TU München, Freising/D

15:00

Lysophosphatidic acid acyltransferase 3 - the missing link between polyunsaturated fatty acids and fertility?
A. Koeberle, University of Jena/D; H. Shindou, T. Harayama, K. Yuki, T. Shimizu, The University of Tokyo/J

15:20 Quantitative chemical proteomics for target deconvolution and biological selectivity analysis
H. Daub, Evotec (München) GmbH, Martinsried/D
15:40 KEYNOTE LECTURE
Target identification with natural products based substances - a pharmaceutical perspective
F. Petersen, Novartis AG, Basel/CH
16:20 Closing
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