11th Status Seminar Chemical Biology

Lecture programme

Tuesday, 19 January 2016

09:00
-12:00
TUTORIAL WORKSHOP

Target Identification – illuminating the interface between chemistry and biology

(separate registration necessary)

   
12:50 Welcome
Chemical Biology of Natural Products
13:00

KEYNOTE LECTURE
Gallic acid-derived polyphenols – from the plant to the cell under the auspices of bacchus

S. Quideau1
¹ IECB Bordeaux/F

13:40

Exploration of chemical signals from microalgae that structure the marine environment

G. Pohnert1
¹ University of Jena/D

14:00 Synthesis of a Brasilicardin A analogue featuring a simplified core
P. Koch¹; M. Jung²
¹ Eberhard Karls Universität Tübingen/D; ² University of California, Los Angeles, Los Angeles/USA
14:20 Natural Products as Sources for the Rational Design of Small-Molecule Myosin Inhibitors
M. Preller¹
¹ Medizinische Hochschule Hannover/D
14:40

KEYNOTE LECTURE
Intelligent design of non-ribosomal peptides by microbes and man
H. Bode1

1 University of Frankfurt/D

15:20 Coffee break
15:40 Investigation of aglycon maturation in the biosynthesis of glycopeptide antibiotics
C. Brieke¹; M. Peschke¹; K. Haslinger¹; M. Cryle¹
¹ Max Planck Institute for Medical Research, Heidelberg/D
16:00 Development of inhibitors for the anti-infective target DXS using ligand-based virtual screening 
A. Hirsch¹
¹ University of Groningen/NL
16:20 Soraphen A - targeting the membrane composition as an innovative approach to fight cancer
K. Stoiber¹; A. Koeberle²; C. Händel³; S. Schmidt³; O. Werz²; J. Käs³; R. Müller⁴; A. Vollmar¹; S. Braig1
¹ Universität München/D; ² University of Jena/D; ³ University of Leipzig/D; ⁴ Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D
16:40 Targeting human sulfation pathways
J. Mueller¹
¹ University of Birmingham/UK 
17:00 Poster short lectures
17:30 Poster party
20:00 EVENING LECTURE

Controlling biological function with photopharmacology

D. Trauner1
1 Universität München/D

20:40 General assembly of the Joint Working Group Chemical Biology

 Wednesday, 20 January 2016

08:40

KEYNOTE LECTURE
A chemical approach to understanding cell division
U. Eggert1
1
King's College London, UK

09:20 Towards a comprehensive strategy to target identification for small molecule drug candidates
M. Schirle1

1 Novartis Institutes for BioMedical Research, Inc., Cambridge, MA/USA

09:40

Increasing biological relevance in vitro: From single microtissues to micro-physiological systems for substance testing
S. Messner1

1 InSphero AG, Schlieren/CH

10:00 Integrating approaches for target identification and elucidation of mechanism of action in phenotypic drug discovery
Y. Rudhard1, I. Sternberger1
1 Evotec AG, Hamburg/D
10:20 KEYNOTE LECTURE
Chromobodies and the fluorescent 2-hybrid assay: new technologies to study proteins and protein interactions in living cells
U. Rothbauer1
1 NMI Reutlingen/D
11:00 Coffee break
11:20 Chemical proteomics for cancer research
G. Médard¹
¹ Univertät München, Freising/D
11:40 Tracking drug action in living cells by thermal profiling of the proteome
M. Savitski¹
¹ Cellzome, Heidelberg/D
12:00 The power of unique CXCR3 allosteric modulators: probe dependence and bias signaling
N. Tschammer¹
¹ University of Erlangen-Nürnberg, Erlangen/D
12:20 Receptor derived peptides and peptide mimetics as chemokine inhibitors
K. Schmitz¹; D. Helmer²; I. Rink¹; J. Dalton³; K. Brahm¹; J. Wack¹; P. Wadhwani²; G. Brenner-Weiss²; J. Giraldo3
¹ TU Darmstadt/D; ² Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen/D; ³ Universitat Autònoma de Barcelona/E
12:40 Lunch break
13:40 KEYNOTE LECTURE
Conformationally arrested peptidomimetics targeting outer membrane proteins in Gram-negative bacteria
J. Robinson1
1 University of Zürich/CH
14:20

Sigma hole bonding in kinase drug discovery

F. Böckler1
1 University of Tübingen/D
14:40 Diverse chemistry to modulate 14-3-3 protein-protein interactions 
C. Ottmann1
1 TU Eindhoven/NL
15:00

Genetic encoding of chemical tools to study G-protein coupled receptors
I. Coin1
1 University of Leipzig/D

15:20 KEYNOTE LECTURE
The discovery of inhibitors of the p53-MDM2 protein-protein interaction
P. Furet1
1 Novartis Pharma AG, Basel/CH
16:00 Closing
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