Programme

• FIS and FIS R&D brief general presentation
• Why biocatalysis in industry
• FIS research model for biocatalysis implementation
• Examples with different enzymes

• The challenge of developing superior enzymes for complex industrial applications
• Multiple parameter optimization of camel chymosin by DoE-based library design
• Combination of various enzyme engineering strategies

12:15

Lunch and networking at the exhibition floor,
Interactive discussions @ "topic tables"

The merit of the enzymes utilized in the reactions which enzymes do better than the chemical reactions will be introduced:

• Hydration and dehydrataion reactions (nitrile hydratase and aldoxime dehydratase)
• Regioselective reaction (acid phosphatase)
• Dynamic kinetic resolution (hydrolysis of nitrile)
• Deracemization of racemic amines (amine oxidase)
• Stereoselective lyase reaction (hydroxynitrile lyase)

• Diverse, exciting application areas for enzymes in F&F
• Different enzyme-based catalyst and reaction formats
• Plug-in solutions for multi-step synthetic schemes (hybrid routes)
• Engineering options help to address performance and cost issues
• Partnering offers unique opportunities

• Identification and characterization of a microbial transglutaminase
  from the spore-forming bacterium Kutzneria albida
• From a promiscuous to a specific enzyme - How digitally controlled
  high-density peptide arrays may predict the best substrates
• Versatile enzyme enabling bio-orthogonal production of active diagnostic and pharmaceutical ingredients on the industrial scale

15:45

Coffee break and networking at the exhibition floor,
Interactive discussions @ "topic tables"

• The importance of speeding up enzyme discovery & development
• Why we use computer simulations to design industrial enzymes
• Case studies from Zymvol Biomodeling

• Enzyme archetypes: Clustering sequence space by functional hotspot positions
• Mutational hotspots: An accelerated molecular dynamics approach
• Enzyme Optimization: Combinatorial library design by virtual prototyping

• White biotechnology is Corden BioChem’s business, your biotech hub in the heart of Europe
• Corden BioChem is an industrial manufacturing partner supplying into food, feed as well as pharma and fine chemical market
• Experienced team for industrialization and scale-up
• Compliance to work with different authorities

• Strategy to optimize new biocatalysts
• Enzyme toolbox
• Case studies

• Integration of biocatalysis into chemical production processes
• Strategies to produce hydroxy-functionalised molecules biocatalytically
• Enzyme and Reaction engineering to optimize biocatalytic processes
• Scale-up of hydratase and monooxygenase reaction

M. Schürmann, Principal Scientist Biocatalysis
InnoSyn / The Netherland

• General overview about the application of enzymes in the whole
  Südzucker group (Inulin, Starch, Isomalt, Ethanol)
• Focus will be enzymes in ethanol production
• Details about the application of α-amylases, glucoamylases,
  proteases, viscosity reducing enzymes, trehalases and phytases

M. Klingeberg, Senior Manager Microbiology
Südzucker / Germany

Coffe break and networking at the exhibition floor,
Interactive discussions @ "topic tables"

• Enzymes are incredibly powerful catalysts – opening new opportunities for the chemical industry
• First applications aimed at chiral intermediates for pharma
• The scope of enzyme catalysis can be extended to high volume petrochemicals

• Identification and characterization of a fibrin degrading protease from the larvae of Lucilia sericata
• Development of a scalable microbial production process for the new enzyme Aurase
• Development of a formulation that enables application of the enzyme product after long storage under unfavourable conditions in order to effectively treat potentially millions of patients worldwide that suffer from painful chronic wounds.

Viral contaminations: a common problem for microbial enzyme production

• Phages – overview
• Phages as contaminants in enzyme production and fermentation processes
• Detection methods
• Corrective actions
• Outlook
  

A. Dreusch, CEO
MicroMol / Germany