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On the basis of a microorganism widely used in industry, an innovative platform for the production of economically relevant chemicals will be created, which - compared to existing systems - allows significantly higher yields and conversion rates. The organism will be able to metabolize lignocellulosic sugars from agricultural waste and convert them into basic and fine chemicals via a novel synthetic metabolic pathway. To this end, the central metabolism is fundamentally altered, thereby enabling a direct coupling of growth and bioproduction. Furthermore, scale-up and product separation processes will be optimized, thus creating industry-relevant conditions. Accompanying analysis of markets, technologies and environmental impacts as well as the involvement of industry representatives guarantee a tailor-made development of processes and products.

Latest publications:

  • Schwardmann, L.S. et al. (2023) Formamide-based production of amines by metabolically engineering Corynebacterium glutamicum. Appl Microbiol Biotechnol doi: 10.1007/s00253-023-12592-3 (link)
  • Schwardmann, L.S. et al. (2023) Nitrogen-controlled Valorization of Xylose-derived Compounds by Metabolically Engineered Corynebacterium glutamicum. Synthetic Biology and Engineering 1, 1–14 (link)
  • Werner F, Schwardmann L, Siebert D, et al. (2023) Metabolic engineering of Corynebacterium glutamicum for fatty alcohol production from glucose and wheat straw hydrolysate. Biotechnology for Biofuels and Bioproducts. (link)
  • K. Wowra, E. Hegel, A. Scharf, A. Grünberger, K. Rosenthal (2023) Estimating environmental impacts of early-stage bioprocesses. Trends in Biotechnology, 2332 (link)
  • S. Wenk, N. J. Claassens, S. N. Lindner, Synthetic metabolism approaches: A valuable resource for systems biology. Current Opinion in Systems Biology, 100417 (2022). (link)
  • E. Orsi, N. J. Claassens, P. I. Nikel, S. N. Lindner, Growth-coupled selection of synthetic modules to accelerate cell factory development. Nature communications 12, 5295 (2021). (link)
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