3D Cell Culture 2014 - Advanced Model Systems, Applications & Enabling Technologies

Poster Programme

(subject to change)

Advanced cell culture models for substance testing

Development of 3D basememt membranes
A. Rossi, K.-H. Heffels, J. Groll, H. Walles, University Hospital Würzburg/D

Dynamic culture of human liver equivalents inside a micro-bioreactor for long-term substance testing
E.M. Materne, I. Wagner, T. Hasenberg, A. Lorenz, K. Schimek, R. Horland, S. Hoffmann, TU Berlin/D; M. Gruchow, F. Sonntag, U. Klotzbach, Fraunhofer IWS, Dresden/D; R. Lauster, TU Berlin/D; U. Marx, TissUse GmbH, Spreenhagen/D

Performance of human intestinal organoid cultures in a microliter-scale multi-organ-chip (MOC) for ADMET testing
A. Jaenicke, N. Sambo, TU Berlin/D; S. Nietzer, C. Tripp, University of Würzburg/D; F. Schmieder, Fraunhofer IWS, Dresden/D; F. Sonntag, Fraunhofer IWS, Dreden/D; H. Walles, University of Würzburg/D; R. Lauster, U. Marx, TU Berlin/D

3D cell culture models for in vitro biocompatibility testing, cell survival and migration studies
A. Lavrentieva, I. Pepelanova, Leibniz Universität Hannover/D; C. Blume, Leibniz Universität Hannover & Hannover Medical School/D; F. Stahl, T. Scheper, Leibniz Universität Hannover/D

Establishment of primary human tissue models of the intestine
M. Schweinlin, S. Wilhelm, H. Walles, M. Metzger, University Hospital of Würzburg/D

Targeted single-chain TRAIL is a potent cytotoxic agent in a 3D model of colorectal cancer
Y. Möller, S. Beyes, M. Siegemund, University of Stuttgart/D; R. Herr, University of Freiburg/D;
D. Lecis, D. Delia, Fondazione IRCCS Istituto Nazionale Tumori, Milan/I; R. Kontermann, University of Stuttgart/D; T. Brummer, University of Freiburg/D; K. Pfizenmaier, M.A. Olayioye, University of Stuttgart/D

Polymer foil scaffold with integrated impedance sensors for 3D tissue culture
G. Blume, C. Goepfert, W. Müller-Wichards, H.K. Trieu, R. Pörtner, Hamburg University of Technology/D

Measurement of angiogenetic and proliferative activity using 3D co-spheroids combining leukemic and different stromal cells
J. Ganesan, H. Weber, S. Umber, O. Siedentopf, D. Feger, M.H.G. Kubbutat, J.E. Ehlert, ProQinase GmbH, Freiburg/D

Optimised media and protocols can significantly improve the barrier function of 3D epidermal keratinocyte models
S. Baertschi, CELLnTEC Advanced Cell Systems, Bern/CH; F. Morf, C. Adlhart, Zurich University of Applied Sciences, Wädenswil/CH; G. Imanidis, University of Applied Sciences and Arts Northwestern, Basel/CH; U. Graf-Hausner, Zurich University of Applied Sciences, Wädenswil/CH; P. Girling, CELLnTEC Advanced Cell Systems, Bern/CH

Artificial micro blood-brain barrier - a microfluidic 3D cell culture model for in vitro drug studies
H. Kiessling, D. Raible, V. Rack, NMI Natural and Medical Sciences Institute, Reutlingen/D;
H. Becker, microfluidic ChipShop GmbH, Jena/D; E. Haltner, Across Barriers GmbH, Saarbrücken/D; M. Stelzle, J. Schütte, NMI Natural and Medical Sciences Institute, Reutlingen/D

Synergistic effect of microencapsulation and 3D configuration for differentiation towards highly functional hepatic cells
S. Rebelo, R. Costa, M. Estrada, IBET / ITQB-UNL, Oeiras/P; C. Chesné, Biopredic International, Rennes/F; C. Brito, IBET / ITQB-UNL, Oeiras/P; P.M. Alves, IBET /ITQB-UNL, Oeiras/P

Development of a 3D-in vitro-Test Model of small-cell lung carcinoma (SCLC)
C. Goepfert, S. Juli, Hamburg University of Technology/D; U. Valentiner, U. Schumacher, University Medical Center Hamburg-Eppendorf/D; R. Pörtner, Hamburg University of Technology/D

3D cell culture for nanoparticle safety testing
F. Sambale, F. Stahl, D. Bahnemann, T. Scheper, Leibniz University Hannover/D

Novel human 3D cell models for neurotoxicity studies
A. Terrasso, L. Ardaya, M. Serra, IBET / ITQB-UNL, Oeiras/P; A.E. Filipe, A.L. Ferreira, P. Pedroso, Tecnimede, Sintra/P; P.M. Alves, C. Brito, IBET / ITQB-UNL, Oeiras/P

Cryogels as a possible novel analysis tool in prostate cancer research
B. Goeppert, F. Keller, A. Baecker, F. Gruhl, Karlsruher Institute of Technology, Eggenstein-Leopoldshafen/D

An in vitro testing strategy for the development of novel inhaled therapeutics using human 3D airway epithelium model (MucilAirTM)
S. Constant, S. Huang, L. Wiszniewski, Epithelix, Plan-les-Ouates/CH

Modelling pharmacokinetics and mass transport in lab-on-chip-systems with SimulationX
M. Busek, F. Schmieder, Fraunhofer IWS, Dresden/D; K. Hofmann, U. Grätz, ITI GmbH, Dresden/D; F. Sonntag, Fraunhofer IWS, Dresden/D

A novel vascular 3D microtissue model for HTS-compatible testing of vaso-constrictors and -dilators
I. Agarkova, InSphero AG, Schlieren/CH; E. Ehler, King's College London/UK; J.M. Kelm, InSphero AG, Schlieren/CH

Standardized high-purity human pancreatic islets amenable to high throughput screening in diabetes research
J. Bourland, R. Prazak, InSphero AG, Schlieren/CH; R. Zuellig, University Hospital, Zurich/CH;
J. Kelm, W. Moritz, InSphero AG, Schlieren/CH

A 3D heterotypic hair-follicle spheroid model for the investigation of diminished hair-growth and hair-growth promoting compounds
T. Hengl, S. Krischok, K. Riegel, Merz Pharmaceuticals, Frankfurt am Main/D; N. Ansari,
E. Stelzer, Goethe University Frankfurt/D; H.F. Abts, Merz Pharmaceuticals, Frankfurt am Main/D

Antioxidative properties of plant extracts tested using a three-dimensional (3D) liver cell model
M.R. Lornejad-Schäfer, K.R. Schröder, C. Schäfer, BioMed-zet Life Science GmbH, Linz/A

A new in vitro approach for studies of bone-oriented materials
B.-S. Kopf, A. Schipanski, EMPA, St. Gallen/CH; S. Berner, Institute Straumann AG, Basel/CH;
K. Maniura-Weber, EMPA, St. Gallen/CH

Targeted therapies of different BRAF-mutated cell lines: establishment of a 3D tumor model using a decellularized intestinal matrix
F. Baur, G. Dandekar, S. Nietzer, H. Walles, Universitätsklinikum Würzburg/D

Re-establishment of hepatic functions of in vitro expanded hepatocytes in 3D culture conditions
C. Lipps, H. Hauser, Helmholtz Centre for Infection Research, Braunschweig/D; P.M. Alves, ITQB-UNL/IBET, Oeiras/P; T. May, InScreenEx GmbH, Braunschweig/D; D. Wirth, Helmholtz Centre for Infection Research, Braunschweig/D

Establishment of a three-dimensional human lung tumor test system applied for the analysis of targeted treatment effects
C. Göttlich, S. Nietzer, G. Dandekar, University Hospital Würzburg/D; H. Walles, Fraunhofer Project Group "Regenerative Technologies in Oncology", Würzburg/D

HepaRG spheroid based assays: transparency into the effects on interior architecture and morphology
R. Richa, F. Pampaloni, E.H.K. Stelzer, Universität Frankfurt/D

Characterisation of 2D and 3D skin models used in genotoxicity and sensitisation assays for ethical and accurate risk assessment
J. Kühnl, Beiersdorf AG, Hamburg/D; R. Fautz, Kao Germany GmbH, Darmstadt/D; K. Reisinger, Henkel AG & Co. KGaA, Düsseldorf/D; G. Quedraogo, L'Oreal Research & Innovation, Aulnay-sous-Bois/F; A. Latil, Pierre Fabre, Toulouse/F; J. Kenny, GlaxoSmithKline, Ware/UK; P. Fowler, Unilever, Sharnbrook/UK; N.H. Hewitt, Cosmetics Europe, Erzhausen/D; M. Klaric, Cosmetics Europe, Brussels/B; S. Pfuhler, Procter & Gamble Co., Cincinnati, OH/USA

Small intestinal submucosa (SIS) matrix induces epithelial morphogenesis of renal proximal tubular cells
A. Hoppensack, University Hospital Würzburg/D; C.C. Kazanecki, Janssen Diagnostics, Inc., Raritan, NJ/USA; D. Colter, Janssen Research & Development, LLC, Springhouse, PA/USA;
J. Schanz, Fraunhofer IGB, Stuttgart/D; H. Walles, University Hospital Würzburg and Fraunhofer IGB, Würzburg/D

Establishment of an intestinal model for oral vaccination testing
C. Lotz, M. Schweinlin, H. Walles, University Hospital Würzburg/D; M. Metzger, Fraunhofer IGB, Würzburg and University Hospital Würzburg/D

Targeting ErbB2-induced, lysosome-mediated invasion
D. Brix, B. Rafn, K. Bundgaard Clemmensen, S. Hagel Andersen, Danish Cancer Society Research Center, Copenhagen/DK; N. Ambartsumian, University of Copenhagen/DK;
M. Jäättelä, K. Kallunki, Danish Cancer Society Research Center, Copenhagen/DK

A co-culture model of human monocytes and mesenchymal stem cells for the investigation of bone remodeling processes
F. Schmid, Fraunhofer IGB, Stuttgart/D; C. Kleinhans, Fraunhofer IGB, Stuttgart/D and University of Stuttgart/D; F. Schmid, Fraunhofer IGB, Stuttgart/D; P.J. Kluger, Fraunhofer IGB, Stuttgart/D and Hochschule Reutlingen/D

The open source reconstructed epidermis - results of a catch-up validation study for skin irritation testing
K.R. Mewes, K. Daton, Henkel AG & Co. KGaA, Düsseldorf/D; L. Schober, A. Traube, Fraunhofer Institute for Manufacturing Engineering and Automation, Stuttgart/D; F. Groeber, H. Walles, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D; H. Gonska,
M. Schäfer-Korting, Freie Universität Berlin/D; S. Hoffmann, seh consulting & services, Paderborn/D; D. Petersohn, Henkel AG & Co. KGaA, Düsseldorf/D

A 3D tissue culture-based ultra-high-content screening platform that uses phenotypic profiling to identify selective inhibitors of receptor tyrosine kinases
M. Klop, OcellO B.V., Leiden/NL; T.H. Booij, Z. Di, B. van de Water, J. Meerman, Leiden University/NL; L.S. Price, Leiden University and OcellO B.V., Leiden/NL

Advanced cell culture models for understanding of diseases

Properties of cryogels as requirements for highly specialized cell culture model systems of prostate cancer cells
A. Baecker, B. Goeppert, J. Oberle, F.J. Gruhl, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen/D

Long-term organ culture of dermal units in a chip based perfusion system
G. Lindner, B. Atac, A. Wanzek, D. Reismann, I. Wagner, R. Horland, TU Berlin/D; F. Sonntag, Fraunhofer IWS, Dresden/D; M. Blechert, Fraunhofer IZM, Berlin/D; R. Lauster, A. Thomas,
U. Marx, TU Berlin/D

Generation of a 3D tissue model for the human airway mucosa to study virulence mechanisms of Bordetella pertussis
M. Steinke, University Hospital of Würzburg/D; R. Gross, S. Bauer, University of Würzburg/D;
T. Walles, H. Walles, University Hospital of Würzburg/D

3D cell culture of bovine mammary epithelial cells from milk - Induction of lactogenesis and former use of the 3D cell culture model
C. Schmautz, M. Hillreiner, M.W. Pfaffl, H. Kliem, TU München/ZIEL, Freising-Weihenstephan/D

An effective hydrogel-based 3D mouse lymphoma cell culture system
H.Y. Kang, M. Ikram, F. Subhan, H.J. Choi, C.W. Hong, S. Yoon, Pusan National University, Yangsan/ROK

Synthesis and evaluation of new type alginate hydrogel for 3D human ovarian cancer cell culture
D.J. Choi, F. Subhan, M. Ikram, H.J. Min, H.Y. Kang, C.W. Hong, S.I. Shin, Y.J. Na, S. Yoon, Pusan National University, Yangsan/ROK

A novel 3D cell culture technique for mouse thymic epithelial cells using nanofiber scaffolds
S.M. Choi, D.J. Choi, H.J. Choi, C.W. Hong, Pusan National University, Yangsan/ROK; Y.H. Jeong, Korea Polytechnic University, Siheung/ROK; J.Y. Kwak, Dong-A University, Busan/ROK; S. Yoon, Pusan National University, Yangsan/ROK

SZ95 sebocytes substitute the sebaceous glands in a co-culture ex vivo skin model
G. Nikolakis, H. Seltmann, A. Hossini, C.C. Zouboulis, Dessau Medical Center/D

Epigenetic boundaries of mesenchymal cells in 3D culture
S. Kadler, Ö. Vural, R. Lauster, M. Rosowski, TU Berlin/D

Mechanisms of ERBB2-driven invasion in breast cancer
A. Balwierz, J. Sonntag, C. Previti, A. Yousaf, German Cancer Research Center, Heidelberg/D;
Ö. Sahin, Bilkent University, Ankara/TR; S. Wiemann, German Cancer Research Center, Heidelberg/D

A novel scalable strategy to study breast tumour-stroma interactions and disease progression
M. Estrada, S. Rebelo, V.E. Santo, iBET / ITQB, Oeiras/P; G. Sflomos, C. Brisken, École Polytechnique Fédérale de Lausanne/CH; E. Anderson, Boehringer Ingelheim, Vienna/A;
P. Alves, C. Brito, iBET / ITQB, Oeiras/P

Primary cultures of human hepatocytes: increased complexity in a spheroid-based model
S. Rebelo, R. Costa, IBET / ITQB-UNL, Oeiras/P; R. Li, Biopredic International, Rennes/F;
C. Brito, P.M. Alves, IBET / ITQB-UNL, Oeiras/P

Novel 3D models of non-small-cell lung carcinoma for target validation and tumour-stroma crosstalk elucidation through bioreactor cultures
V.E. Santo, M. Estrada, S.C. Veloso, M.F.Q. Sousa, iBET, Oeiras/P; H. van der Kuip, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart/D; M. Oren, The Weizmann Institute, Rehovot/IL; E.R. Boghaert, AbbVie, Chicago, IL/USA; P.M. Alves, C. Brito, iBET, Oeiras/P

An in vitro tumor-stroma co-culture model using a biomimetic hydrogel and Raman spectroscopy analysis
C. Hoffmann, B. Angres, Cellendes GmbH, Reutlingen/D; K. Schütze, R. Gangnus, CellTool GmbH, Bernried/D

Use of a new 3D-model of human liver to study the infection of a flavivirus, the Yellow Fever virus
N. Masse-Deragon, N. Mantel, Sanofi Pasteur, Lyon/F; C. Legras-Lachuer, Plateforme ProfileXpert, Lyon/F; V. Barban, Sanofi Pasteur, Lyon/F

Multicolor clonal cell tracking in mammary epithelial spheroids
J. Neugebauer, L. Maier, J.-P. Bergeest, R. Eils, C. Conrad, German Cancer Research Center, Heidelberg/D

Establishment of a 3D mamma carcinoma test system on a decellularized scaffold
L. Müller, H. Walles, Fraunhofer Project Group "Regenerative Technologies in Oncology", Würzburg/D; S. Nietzer, G. Dandekar, University Hospital Würzburg/D

Studying cancer mechanobiology in the 3D tissue models. How matrix tension drives metastasis?
K.S. Kopanska, T. Betz, Institute Curie, Paris/F

Injectable hydrogels for tissue neo-vascularization
A. Forget, Universität Freiburg/D; R. Gianni'Barbera, B. Fogli, A. Banfi, University Hospital Basel/CH; P.V. Shastri, Universität Freiburg/D

Novel tissue engineered human 3D infection models to study pathogenesis of Helicobacter pylori and Campylobacter jejuni
M. Alzheimer, S.M. Tirier, University of Würzburg/D; M. Schweinlin, M. Metzger, H. Walles, University Hospital Würzburg/D; C.M. Sharma, University of Würzburg/D

Skin reconstructed as a platform to study MMPs production in tumoral invasion of melanoma tumor cells resistant to BRAF inhibitor
S. Silvana Sandri, F. Faião-Flores, P.C. Pennacchi, M. Tiago, P. Casari, R.R. Massaro,
S.S. Maria-Engler, University of São Paulo/BR

3D cell culture of functional beta-cells within a peptide hydrogel
L. Byrne, B. Furman, R.V. Ulijn, University of Strathclyde, Glasgow/UK

Analysis of isogenic glioblastoma U251MG cell lines in 2D- and 3D-culture with respect to invasion and migration
H. Kuhn, A. Holloschi, University of Applied Sciences Mannheim/D; J. Mollenhauer, University of Southern Denmark, Odense/DK; P. Kioschis, University of Applied Sciences Mannheim/D

Comparison of different methods to generate spheroids with special emphasis on the glioblastoma U251MG cell line
H. Kuhn, A. Holloschi, University of Applied Sciences Mannheim/D; J. Mollenhauer, University of Southern Denmark, Odense/DK; P. Kioschis, University of Applied Sciences Mannheim/D

A biohybrid microfluidic system for an in vitro analysis of tumor metastases through blood vessels
S. Kayo, HSG-IMIT, Villingen-Schwenningen/D; C. Kuehlbach, J. Sechi, Furtwangen University, Villingen-Schwenningen/D; H. Hoefemann, S. Herrlich, R. Zengerle, HSG-IMIT, Villingen-Schwenningen/D; M. Mueller, Furtwangen University, Villingen-Schwenningen/D

Establishment of a standardized 3D in vitro tumor-stroma model
S. Hensler, B. Kotkamp, Hochschule Furtwangen University, Villingen-Schwenningen/D; K.I. Pohl, University of Applied Sciences, Albstadt-Sigmaringen/D; N. Linde, Laboratory of Signaling and Metastasis Mount Sinai School of Medicine, New York/USA; D. Stoll, University of Applied Sciences, Albstadt-Sigmaringen/D; M.M. Müller, Hochschule Furtwangen University, Villingen-Schwenningen/D

Adult stem cells based 3D primary cultures from human epithelial tissues as model to study infection and disease
M. Kessler, A. Imai-Matsushima, P. Schlaermann, K. Hoffmann, B. Toelle, L. Martin-Sancho, Max Planck Institute for Infection Biology, Berlin/D; M. Glanemann, S.C. Schmidt, Charite University Medicine, Berlin/D; J. Ordemann, Charite Univeristy Medicine, Berlin/D; C. Fotopuolou, Imperial College, London/UK; M. Mangler, Charite University Medicine, Berlin/D; A.C. Hocke, Charite university Medicine, Berlin/D; S. Hippenstiel, Charite University Medicine, Berlin/D; T.F. Meyer, Max Planck Institute for Infection Biology, Berlin/D

Using microfluidic culture conditions in a 3D co-culture model to study the effect of environmental impacts on the airway mucosa
C. Blume, E.J. Swindle, M. Held, R. Reale, J.E. Collins, T.M. Millar, H. Morgan, D.E. Davies, University of Southampton/UK

High content drug screening for cystic fibrosis using patient derived organoids
B. Herpers, OcellO B.V., Leiden/NL; F. Dekkers, UMC Utrecht/NL; L.S. Price, Leiden University and OcellO B.V., Leiden/NL; J. Beekman, UMC Utrecht/NL

Advanced cell culture models for ADME - safety testing of drugs

Long-term in vitro 3D co-cultured human liver microtissues: characterization and implication for drug-induced hepatotoxicity studies
P. Gunness, S. Messner, InSphero AG, Schlieren/CH; L. Fredriksson, Karolinska Institutet, Stockholm/S; J. Kelm, W. Moritz, InSphero AG, Schlieren/CH; M. Ingelman-Sundberg, Karolinska Institutet, Stockholm/S

3D Organotypic cultures of liver cells for metabolism and toxicity testing
F. Noor, D. Mueller, S. Klein, P. Gunness, V. Shevchenko, E. Heinzle, M. Ingelman-Sundberg, Saarland University, Saarbrücken/D

A novel two-circuit microfluidic device for simulation of the kidney proximal tubule and ADMET profiling
C. Drewell, A. Ramme, TU Berlin/D; L. Aschauer, P. Jennings, Innsbruck Medical University/A;
F. Schmieder, F. Sonntag, Fraunhofer IWS Dresden/D; R. Lauster, TU Berlin/D; U. Marx, TissUse GmbH, Spreenhagen/D

Cytochrome P450 activity and bile acid analysis in advanced hepatocyte cultures
M. Mayer, U. Müller-Vieira, J. Sennhauser, K.M. Biemel, Pharmacelsus GmbH, Saarbrücken/D

Advanced cell culture models for industrial applications

Core-shell microbeads for cultivation of mammalian cells in 3-D suspension environment
F. Rüdinger, Leibniz Universität Hannover/D; D. Seliktar, Israel Institute of Technology, Haifa/IL;
T. Scheper, Leibniz Universität Hannover/D

Improving cell based models through viral vector technology - chances for target research and personalized treatment strategies
M. Salomon, V. Jagusch, Sirion Biotech GmbH, Martinsried/D; N. Anastasov, I. Höfig, Helmholtz Zentrum München, Neuherberg/D; J. Kelm, InSphero AG, Schlieren/CH; K. Schmitt, C. Thirion, Sirion Biotech GmbH, Martinsried/D

More physiologically relevant cellular models compatible with high content analysis
J. Young, E. Duchemin-Pelletier, F. Monjaret, D. Morales, J. Michaud, P. Poydenot, Y. Margaron,
M. Fernandes, S. Degot, CYTOO, Grenoble/F

Advanced cell culture models for evolving from organ to body on a chip

Establishing a physiological vasculature in a dynamically perfused multi-organ-chip (MOC) microbioreactor
T. Hasenberg, K. Schimek, TU Berlin/D; M. Busek, Fraunhofer IWS, Dresden/D; S. Brincker,
B. Groth, A. Lorenz, R. Horland, S. Hoffmann, TU Berlin/D; F. Sonntag, U. Klotzbach, Fraunhofer IWS, Dresden/D; R. Lauster, TU Berlin/D; U. Marx, TU Berlin and TissUse GmbH/D

"Skin and liver on a chip" - perfused long term co-culture of skin and liver tissue
I. Wagner, E. Matern, A. Lorenz, A. Jaenicke, TU Berlin/D; F. Sonntag, Fraunhofer IWS, Dresden/D; R. Lauster, U. Marx, TU Berlin/D

Permeation of a fluorescent substance trough a gel matrix in a multi-organ-chip and simulation of this system with COMSOL multiphysics
H. Hsu, Hamburg University of Technology/D; G. Lindner, TU Berlin/D; F. Sonntag, Fraunhofer IWS, Dresden/D; U. Marx, TU Berlin/D; R. Pörtner, Hamburg University of Technology/D

Enabling technologies - devices for 3D cell culture

Bioreactor-based 3D cell culture systems under perfusion
A. Papadimitropoulos, Cellec Biotek AG, Basel/CH; I. Martin, University Hospital Basel/CH

Mimetix® electrospun scaffolds for 3D cell culture of upcyte® and primary human hepatocytes
E. Heister, R. McKean, The Electrospinning Company Ltd., Didcot/UK; S. Ramachandran, Medicyte GmbH, Heidelberg/D; B. Burkhardt, A. Nüssler, University of Tübingen/D

Electrospun scaffolds for 3D culture of human epithelial breast cancer cells
E. Heister, R. McKean, The Electrospinning Company Ltd., Didcot/UK; H. McLuskey, T. Duff,
C. Wilde, Avanticell Ltd., Ayr/UK

Dynamically perfused chip-based platform for 3D in vitro hair follicle cultures
B. Ataç, TU Berlin/D; S. Giselbrecht, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen/D; G. Lindner, R. Horland, C. Magauer, R. Lauster, U. Marx, TU Berlin/D

Dynamic 3D cell microenvironments with phototunable characteristics
L. García-Fernández, A. del Campo, MPI für Polymerforschung, Mainz/D

A novel method for rapid assembly of microtissues
C. Millan, M. Zenobi-Wong, ETH Zurich/CH

Complex tissue models fabricated by 3D plotting of cells suspended in biopolymer hydrogels
A. Lode, K. Schütz, A.M. Placht, B. Hoyer, M. Gelinsky, TU Dresden/D

Simple and robust microfluidic platform for spheroid culturing
J. Kim, A. Hierlemann, O. Frey, ETH Zurich, Basel/CH

A standardized 3D clonogenic assay using a microstructured hydrogel
A.R. Thomsen, N. Melin, C. Aldrian, C. Zamboglou, N. Wiedenmann, M.-B. Messmer, N. Nanko, A.-L. Grosu, G. Niedermann, University Hospital of Freiburg/D

NanoCulture®Plates: 3D cell culture featuring the ease-of-use, scalability and automatibility of conventional 2D systems
K. Buyens, JSR Micro NV, Leuven/B; H. Miura, Scivax USA Inc., Woburn/USA; K. Arai, M. Itoh, Scivax Life Sciences Inc., Kawasaki/J

Platform technology for routine generation of advanced organotypic three dimensional cell culture models
S. Przyborski, Durham University/UK

Hollow fiber-based lab-on-a-chip dual perfusion system with integrated fluorescence-based oxygen monitoring
C. Winkelmann, F. Schmieder, S. Grünzner, Fraunhofer IWS, Dresden/D; U. Marx, TU Berlin, Berlin/D; F. Sonntag, Fraunhofer IWS, Dresden/D

Multilayer based lab-on-chip-systems for substance testing
F. Sonntag, H. Stehr, R. Eger, Fraunhofer IWS, Dresden/D; U. Marx, TU Berlin/D; U. Klotzbach,
V. Franke, Fraunhofer IWS, Dresden/D

NovaMatrix®-3D: an alginate-based 3D cell culture system
T. Andersen, M. Dornish, BioPolymer AS/NovaMatrix, Sandvika/N

Validation of a novel tumoroid-based cell culture model to perform 3D in vitro cell signaling analyses
B. Larson, BioTek Instruments, Inc., Winooski, VT/USA; G. Cameron, TAP Biosystems, Royston/UK; N. Pierre, Cisbio Bioassays, Codolet/F; P. Banks, BioTek Instruments, Inc., Winooski, VT/USA

Use of Schwann cell-seeded nanofiber as nerve conduit
W.T. Tung, K.W. Tam, Y.S. Chan, D.K.Y. Shum, The University of Hong Kong/PRC

Immediate drop on demand technology - new platform for cell applications and toxicity testing
L. Schober, C. Laske, E. Büttner, T. Brode, A.F. Traube, A. Traube, Fraunhofer Institute for Manufacturing Engineering and Automation IPA, Stuttgart/D

Organotypic 3D cell culture engineering in core-shell hydrogels
A. Funfak, N. Atrux-Tallau, H. Doméjean, N. Bremond, J. Baudry, ESPCI, Paris/F; G. Rousseau, ESPCI, Paris/F and UPMC, Paris/F; M.C. Giarratana, L. Douay, UPMC, Paris/F; K. Alessandri,
V.V. Gurchenkov, Institut Curie, Paris/F; P. Nassoy, Institut d'Optique d'Aquitaine, Talence/F;
J. Bibette, ESPCI, Paris/F

Nanofibrillar cellulose hydrogel provides a 3D scaffold for liver cell culturing
L. Kanninen, M. Malinen, M. Bhattacharya, Y-R. Lou, P. Lauren, R. Harjumäki, University of Helsinki/FIN; A. Corlu, Université de Rennes 1/F; H. Isoniemi, The Hospital District of Helsinki and Uusimaa/FIN; A. Urtti, M. Yliperttula, University of Helsinki/FIN

Enabling technologies - imaging technologies

Handling, automatization and substance testing in multi-organ-chips
L. Kloke, A. Jaenicke, A. Ramme, K. Schimek, R. Horland, M. Busek, F. Schmieder, C. Polk, TU Berlin/D; F. Sonntag, U. Klotzbach, Fraunhofer IWS, Dresden/D; R. Lauster, U. Marx, TU Berlin/D; V. Artyushenko, ART Photonics GmbH, Berlin/D; M. Bürger, GeSiM mbh, Großerkmannsdorf/D

Monitoring metabolic processes in 3D biomaterials with chemical optical sensors
G. Liebsch, D. Achatz, PreSens Precision Sensing GmbH, Regensburg/D

The automated FADU-assay to quantify formation and repair of DNA strand breaks - a rapid and meaningful genotoxicity quantification
H. Käser, M. Pilartz, M. Unger, Cetics Healthcare Technologies GmbH, Esslingen/D; M. Moreno-Villanueva, University of Konstanz/D; D. Dressler, K. Engelhart-Jentzsch, I. Pfitzner, BioTeSys GmbH, Esslingen/D

Simplifying high throughput 3D tumour spheroid growth and shrinkage assays using live content imaging
T. Dale, K. Patel, T. O’Callaghan, D. Trezise, Essen BioScience, Welwyn Garden City/UK;
B. O'Clair, D. Appledorn, Essen BioScience, Ann Arbor, MI/USA

TissueSurgeon - laser based multipurpose instrument for 3D-tissue culture imaging and processing
H. Richter, F. Will, B. Stolze, LLS ROWIAK LaserLabSolutions GmbH, Hannover/D

Enabling technologies - systems biology

Unbiased discovery of acetaminophen toxicity in 3D human liver microtissues by global proteomic analysis
C. Escher, R. Ossala, Biognosys AG, Schlieren/CH; P. Gunness, InSphero AG, Schlieren/CH;
M. Bober, F. Grimm, L. Reiter, Y. Butscheid, Biognosys AG, Schlieren/CH; S. Messner, InSphero AG, Schlieren/CH

Dynamic hydrogels for the study of cell-materials interactions
L. Garcia-Fernandez, A. del Campo, Max-Planck-Institut für Polymerforschung, Mainz/D

Ultra high content analysis and phenotype profiling of 3D cultured breast cancer microtissues
Z. Di, Leiden University/NL; K. Yan, M.J.D. Klop, OcellO B.V., Leiden/NL; S. van Asten,
V.-M. Rogkoti, Leiden University/NL; G. Keri, Vichem Chemie, Budapest/H; B. van de Water,
F.J. Verbeek, Leiden University/NL; L.S. Price, Leiden University and OcellO B.V., Leiden/NL; J.H.N. Meerman, Leiden University/NL

Enabling technologies - stem cells

Novel 3D culture approaches for the scalable production of pure cardiomyocytes derived from iPSC
C. Correia, M. Serra, M. Sousa, N. Espinha, C. Brito, ITQB-UNL / IBET, Oeiras/P; K. Burkert,
A. Fatima, J. Hescheler, University of Cologne/D; M.J.T. Carrondo, FCT / IBET, Oeiras/P; T. Saric, University of Cologne/D; P.M. Alves, ITQB-UNL / IBET, Oeiras/P

New defined cell culture conditions in combination with a 3D-scaffold for ASCs bone tissue engineering
M. Corazza, G. Minonzio, L. Mariotta, Swiss Stem Cell Foundation, Gentilino/CH; M. Gola, Stem Cell Research, Gentilino/CH; G. Soldati, Swiss Stem Cell Foundation, Gentilino/CH

Microtissue arrays as organotypic high-throughput-/high-content-analysis tissue models
E. Gottwald, S. Giselbrecht, R. Truckenmüller, P. Haug, 300Microns, Eggenstein-Leopoldshafen/D

Microcarrier-based expansion of bone marrow-derived human mesenchymal stem cells in clinically relevant doses
A. Ott, V. Jossen, S. Kaiser, Zurich University of Applied Sciences, Wädenswil/CH; A. Siehoff,
S. Brill, A. Safavi-Nab, F. Jüngerkes, Lonza Cologne GmbH/D; J. Herrmann, A. Tappe, Sartorius Stedim Biotech, Göttingen/D; C. van den Bos, Lonza Cologne GmbH/D; D. Eibl, R. Eibl, Zurich University of Applied Sciences, Wädenswil/CH

Nanofibrillar cellulose hydrogel supports three-dimensional culture of human pluripotent stem cells
Y-R. Lou, L. Kanninen, T. Kuisma, J. Niklander, University of Helsinki/FIN; L. Noon, D. Burks, Principe Felipe Centro de Investigacion, Valencia/E; A. Urtti, M. Yliperttula, University of Helsinki/FIN







Poster programme on 3D cell culture model systems, applications and enabling technologies
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