11th Status Seminar Chemical Biology

Poster programme

Chemical biology of natural products
P 1.01 Labyrinthopeptins – new lantibiotics with broad anti-viral activity
H. Prochnow¹; S. Birudukota1,S. Blockus²; S. Gordts4, S. Haid²; T. Pietschmann²; T. Schulz³; D. Schols⁴; M. Brönstrup1
¹ Helmholtz Centre for Infection Research, Braunschweig/D; ² TWINCORE, Centre for Experimental and Clinical Infection Research GmbH, Hannover/D; ³ Hannover Medical School/D; German Center for Infection Research (DZIF), Hannover/D; ⁴ University of Leuven/B
P 1.02 Synthetic strategy towards cystobactamid analogs
G. Testolin¹; H. Prochnow¹; M. Brönstrup¹
¹ Helmholtz Centre for Infection Research, Braunschweig/D
P 1.03 Synthesis of natural products from entomophatogenic bacteria and their fluorescent analogs for use in visual imaging
F. Wesche¹; H. Adihou1; H. Bode1
² University of Frankfurt/D
P 1.04 MS-based structure and biosynthesis elucidation of stackepeptins – supersized class III lanthipeptides
N. Jungmann¹; E. van Herwerden¹; M. Hügelland¹; R. Süssmuth¹
¹ TU Berlin /D
P 1.05 A fluorogenic dye-based system for monitoring bacterial compound uptake
V. Fetz¹; K. Ferreira¹; H. Hu²; M. Brönstrup¹
¹ Helmholtz Centre for Infection Research, Braunschweig/D; ² Institute of Materia Medica, Beijing/CN
P 1.06 From insects to hydrozoa: communication strategies in microbe-host interactions
C. Beemelmanns¹
¹ Hans-Knöll-Institut Jena/D
P 1.07 Blending chemoproteomics and structural biology - the discovery of a selective EphA2 inhibitor
S. Heinzlmeir¹; G. Médard²; D. Kudlinzki³; S. Gande³; V. Linhard³; K. Saxena³; J. Lohse²; T. Treiber²; H. Schwalbe³; B. Kuster¹
¹ DKTK Munich and TU München, Freising/D; ² TU München/D; ³ DKTK Frankfurt and University of Frankfurt/D
P 1.08

Guideline for reprogramming non-ribosomal peptide synthetases

K. Bozhüyük¹; F. Fleischhacker1

¹ Goethe-Universität Frankfurt am Main/D

P 1.09

Understanding iterative nonribosomal peptide synthetases from Xenorhabdus KJ12.1

S. Nowak¹

¹ Goethe-Universität Frankfurt am Main/D

Phenotypic Screening
P 2.01 Phenotypic screening with Ras-FRET biosensors identifies cancer stem cell inhibitors
D. Abankwa¹
¹ Åbo Akademi, Turku/FIN
P 2.02 MALDI mass spectrometry imaging enables simultaneous measurement of donepezil distribution and its pharmacological efficacy in-Situ in rat brain
S. Schulz¹; B. Meyer¹; J. Fuchser²; C. Hopf¹
¹ University of Applied Sciences Mannheim/D; ² Bruker Daltonik GmbH, Bremen/D
P 2.03

Cell separation by small molecule - protein interaction using capture compounds

T. Lenz¹; C. Dalhoff¹; M. Sefkow¹; M. Dreger¹; H. Köster¹

¹ caprotec Bioanalytics GmbH, Berlin/D

P 2.04

Screening for inhibitors of the Escherichia coli outer membrane channel TolC

S. Schrüfer¹; W. Tegge¹; M. Brönstrup¹; U. Bilitewski¹

¹ Helmholtz-Zentrum für Infektionsforschung (HZI), Braunschweig/D

Protein-protein interaction
P 3.01

Contact area extension defines the interaction specificity of conserved enzymatic subunits and unlinks two essential metabolic pathways

F. Semmelmann¹

¹ University of Regensburg/D

P 3.02

Exploring the molecular mechanism of viral interference

R. Hoffmann¹; J. Schaubächer²; B. Schmidt²; J. Eichler¹

¹ FAU Erlangen-Nürnberg, Erlangen/D; ² Universität Regensburg/D

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