In recent years, Advanced Therapy Medicinal Products (ATMP) have evolved into a promising and highly hoped-for medical approach to cure a broad spectrum of inherited and acquired human diseases, ranging from cancer to immunological disorders and rare diseases. However, the path from development to clinical application is not yet routine.
The conference will highlight the challenging field of gene and cell therapeutics.
Advances in development and manufacturing will be presented at ATMP 2022, as well as quality control methods and regulatory aspects: The focus is on the path to safe and beneficial advanced therapies for the patient.
The registration is open:
| 10:00 | Registration |
|---|---|
| 11:00 | Welcome |
| Session: Innovative iPSC- and MSC-derived therapeutics Chair: Roland Wagner, Technical University Braunschweig |
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| 11:05 |
Keynote lecture: "Scalable generation of custom-made immune cells for innovative cell-based immunotherapies and industrial applications" Nico Lachmann, MHH Medizinische Hochschule Hannover |
| 11:45 |
"Process design considerations for hMSC-based products" Jan Barekzai; Florian Petry; Peter Czermak; Denise Salzig, |
| 12:05 |
Poster talk: "Biomimetic matrices enable highly defined isolation of functional mesenchymal stromal cells in xeno-/serum-free media" Kristina Thamm¹; Kristin Moebus²; Russel Towers²; Richard Wetzel¹; |
| 12:10 |
Short break |
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Session: Therapeutic exosomes |
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| 12:20 |
Keynote lecture: "Functional extracellular vesicles as new therapeutic modality – Exosomes’ Road to the clinic" Jens Gruber, Curexsys GmbH, Göttingen |
| 13:00 |
Poster talk: "Challenges and Solutions for Production of Therapeutic Exosomes" |
| 13:05 |
Lunch |
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Session: New approaches in cell-based therapies |
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| 14:00 |
Keynote lecture: "Engineering T cell receptors for adoptive cell therapy" Kilian Schober, Universitätsklinikum Erlangen |
| 14:40 |
"Cell-mediated visualization of local infections and drug delivery " Dagmar Wirth¹; Mario Köster¹; Sandhya Kumar¹; Peter Behrens²; Hansjörg Hauser¹; Andreas Kirschning³, ¹ Helmholtz Zentrum für Infektionsforschung mbH; ² Institute for Anorganic Chemistry; Leibniz University Hannover; ³ Institute for Organic Chemistry, Leibnitz University Hannover |
| 15:00 |
Keynote lecture: "Harnessing human 3D Cell Models to accelerate the development of advanced therapies" Catarina Brito, iBET & ITQB-NOVA, Oeiras/Portugal |
| 15:40 | Coffee break |
| Session: Tumor vaccines - strategies for personalisation and production Chair: Jessica Horbelt, Fraunhofer IPA, Stuttgart |
|
| 16:15 |
Keynote lecture: "Application of mRNA technology in cancer therapy" Felicitas Müller, BioNTech SE, Mainz |
| 16:55 |
"Improved production strategies for oncolytic Measles virus as therapeutic Dustin Eckhardt; Denise Salzig; Peter Czermak, Technische Hochschule Mittelhessen |
| 17:15 | End of lecture programme of day 1 |
| 17:30 - 20:00 | Get Together / Poster Session |
| Session: Clinical ATMP application and manufacturing Chair: Andrea Traube, KyooBe Tech GmbH, Leinfelden-Echterdingen |
|
| 09:00 |
Keynote lecture: "Home brewn CAR-T-Cell" Michael Schmitt, Uniklinik Heidelberg, Heidelberg |
| 09:40 |
"Running title: Modular mini-factories for the automated and scalable production of ATMPs" Andreas Traube; Jessica Horbelt; Martin Thoma; Natalie Gebken; Sarah Kleine-Wechelmann; Milena Frahm; Markus Schandar; Michael Klinger; Sebastian Puls; Rolf Wössner; Michael Pfeifer; Tobias Sauer, Fraunhofer IPA |
| 10:00 |
"Real laboratory for automated and digitalized ATMP production" Georg Popp¹; Rolf van Lengen²; Andreas Traube³; Karsten Seidl⁴; Carsten Claussen⁵; Michael Baßler⁶; Paul Franz¹; Anna Dünkel¹; Ulrike Köhl¹; Stephan Fricke¹, |
| 10:20 | Coffee break |
| Session: Innovative production strategies Chair: Anna Katharina Heide, RUHR-IP Patentanwälte, Essen |
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| 11:00 | Keynote lecture: "Single Cell Multi-Omics Driving the Future of Adoptive Cell Therapy" Andreas Schmidt, Singleron Biotechnologies GmbH, Köln/D |
| 11:40 | "AIDPATH – Modular Manufacturing Platform for AI-enabled hospital-based ATMP Production – A Concept Presentation" Frederik Erkens, Fraunhofer Institute for Production Technology IPT |
| 12:00 | Poster talk: "Fluidic imaging as PAT tool for cell aggregate monitoring" Martin Kraft, Bayer AG |
| 12:05 |
Keynote lecture: "Tackling the Challenges of AAV Vector Manufacturing" Nicole Faust, CEVEC Pharmaceuticals GmbH, Köln |
| 12:45 | Lunch |
| Session: From regulatory framework to clinical application Chair: Hansjörg Hauser, Helmholtz Centre for Infection Research, Braunschweig |
|
| 13:30 |
"Risk Assessment – An intelligent tool for the evaluation of critical starting material" Claudia Papewalis¹; Marco Schmeer²; Martin Schleef², ¹ Valicare GmbH; |
| 13:50 |
"Plausibility of EP Patents - Post-filed experimental data as support of Anna Katharina Heide, RUHR-IP Patentanwälte, Essen |
| 14:10 |
"The current regulatory framework of ATMP storage and distribution – consequences and challenges " Andrea Zobel, World Courier |
| 14:30 | Coffee & Networking |
| 15:00 |
End of conference |
(as of 9 May 2022, subject to change)
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Catarina Brito
Keynote lecture: „Harnessing human 3D Cell Models to accelerate the development of advanced therapies“
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|---|---|
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Nicole Faust
Keynote lecture: "Tackling the Challenges of AAV Vector Manufacturing" |
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Jens Gruber
Keynote lecture: "Functional extracellular vesicles as new therapeutic modality – Exosomes’ Road to the clinic"
|
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Nico Lachmann
Keynote lecture: "Scalable generation of custom-made immune cells for innovative cell-based immunotherapies and industrial applications"
His statement: "Technical innovations along with stem cell technologies pave the way for the development of novel cells and ATMPs for innovative industrial applications and future immunotherapies, respectively." |
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Felicitas Müller
Keynote lecture: "Application of mRNA technology in cancer therapy" |
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Andreas Schmidt
Keynote lecture: "Single Cell Multi-Omics Driving the Future of Adoptive Cell Therapy"
|
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Michael Schmitt Keynote lecture: „Home brewn CAR-T-Cell“ |
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Kilian Schober (Universitätsklinikum Erlangen/D)
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The conference will highlight the challenging field of gene and cell therapeutic approaches, especially focusing on the following topics:
Ulf Bethke
Miltenyi Biotec GmbH, Bergisch Gladbach
Hansjörg Hauser
Helmholtz Centre for Infection Research, Braunschweig
Anna Katharina Heide
RUHR-IP, Essen
Jessica Horbelt
Fraunhofer IPA, Stuttgart
Cornelia Kasper
University of Natural Resources and Life Sciences, Vienna
Konrad Kohler
BioMedTech, Forschungscampus Reutlingen
Thomas Noll
University of Bielefeld
Ralf Pörtner
Technical University Hamburg
Denise Salzig
University of Applied Sciences Mittelhessen, Gießen
Bernd Schröder
Miltenyi Biotec GmbH, Teterow
Karin Tiemann
DECHEMA e.V., Frankfurt am Main
Andrea Traube
KyooBe Tech GmbH, Leinfelden-Echterdingen
Roland Wagner
Technical University Braunschweig
The challenges and issues of manufacturing and analytics of gene and cell therapeutics are very different from all other therapeutics, including biopharmaceuticals. A key factor of success is the management of multiple challenges addressing safety, purity and potency of these advanced therapies.
Robust and reliable manufacturing processes are still far from routine. Efficient gene transfer vectors, delivering the therapeutic gene into the target cells without causing any associated pathogenic effect, need to be developed and produced in large-scale.
Depending on the complexity and individuality of this product class, cell therapy manufacturing processes may comprise consistent procedures of culture, expansion, genetic manipulation, stimulation, and in case of treatments of multiple patients, cell banking. Analytics and quality control need to be adapted to this broad range of complex manufacturing processes ensuring adequate safety, purity and potency of the final products.
The conference is an initiative of the DECHEMA working groups Cell Culture Technology and Medical Biotechnology.
Mehr Informationen: Programme Keynote 2022 Conference Topics Committee Privacy Policy Terms & Conditions
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