10:30 Welcome address
Chair: J.D. Hoheisel, German Cancer Research Center, Heidelberg
10:40 Differentiation of murine ESCs to cardiomyocytes: miRNA profiling, transcriptome
analysis and their interaction
L. Gan, RWTH Aachen; S. Schwengberg, Axiogenesis AG, Cologne; B. Denecke, RWTH
Aachen
11:00 Somatic mutations in acute promyelocytic leukemia (APL) identified by exome
sequencing
P.A. Greif, LMU Munich / Helmholtz Zentrum Munich; M. Yaghmaie, Tehran University of
Medical Sciences/IR; N.P. Konstandin, LMU Munich / Helmholtz Zentrum Munich;
K. Alimoghaddam, A. Ghavamzadeh, Tehran University of Medical Sciences; A. Hauser,
A. Graf, S. Krebs, H. Blum, LMU Munich; S.K. Bohlander, LMU Munich / Helmholtz Zentrum
Munich
11:20 Fully-automated electrochemical biochip platform for rapid, simultaneous and
sensitive bioagent detection
C. Pöhlmann, T. Elßner, Bruker Daltonik GmbH, Leipzig
11:40 Coffee break and poster viewing
Chair: T. Joos, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen
12:00 Parallel proteomics and gene expression analysis of breast cancer
J. Budczies, C. Denkert, Charité - Universitätsmedizin Berlin; O. Fiehn, B. Perroud,
University of California, Davis, CA/USA
12:20 Identification of drug-associated proteins in NSCLC xenograft models by
reverse-phase-protein-arrays
H. Hülsmann, German Cancer Research Center / National Center for Tumor Diseases,
Heidelberg; C. Bender, German Cancer Research Center, Heidelberg; J. Rolff,
Experimental Pharmacology & Oncology Berlin-Buch GmbH / Max-Delbrück-Center, Berlin;
I. Fichtner, Max-Delbrück-Center, Berlin; R. Herwig, MPI for Molecular Genetics, Berlin;
U. Korf, German Cancer Research Center, Heidelberg; H. Sültmann, R. Kuner, German
Cancer Research Center / National Center for Tumor Diseases, Heidelberg
12:40 Systematic high-throughput / high content analysis of the immune-proteome using
chip-based arrays and bead-based suspension arrays
H. Goehler, J. Schwermann, P. Pews, V. Trappe, K. Marquardt, D. Chamrad, A. Lueking,
P. Schulz-Knappe, Protagen AG, Dortmund; T. Joos, N. Schneiderhan-Marra, NMI Natural
and Medical Sciences Institute at the University of Tübingen, Reutlingen
13:00 Lunch
Chiar: T. Gress, Marburg University Hospital
14:30 Challenges in the planning and statistical analysis of diagnostic studies
A. Ziegler, Universität zu Lübeck
15:00 Validation of biomarkers: challenges from the pharmaceutical industry view
K. Dücker, Merck KGaA, Darmstadt
15:20 Validation of biomarkers: life cell-based assay for the detection of functionally
activating adrenoceptor autoantibodies in heart failure
R. Jahns, Würzburg University Hospital
15:40 Pitfalls and perspectives of molecular diagnostics studies: a personal view
M. Stürzl, University of Erlangen-Nuremberg
16:00 Coffee break and poster viewing
16:30 PLENARY LECTURE
Chair: M. Hrabĕ de Angelis, German Research Center for Environmental Health, Munich
& TU München
The dynamic of epigenomic landscapes in development and disease
J. Walter, University of Saarland, Saarbrücken
17:15 PANEL DISCUSSION
Systems biology - fact or fiction?
18:15 Poster party
20:30 End of the first day
Chair: M. Buchholz, Marburg University Hospital
9:15 Effective lead selection for improved protein production in Aspergillus niger based on
integrated genomics
I. Jacobs, M.A. Olsthoorn, DSM Biotechnology Center, Delft/NL; I. Maillet, DSM Nutritional
Products, Basel/CH; M. Akeroyd, S. Breestraat, DSM Biotechnology Center, Delft/NL;
A.M.J.J. Cees, R. Kooistra, Leiden University/NL; H. Menke, DSM Biotechnology Center,
Delft/NL; W. Muller, Utrecht University/NL; N.M.E. Peij, DSM Biotechnology Center, Delft/NL;
A. Ram, Leiden University/NL; J. Verkleij, Utrecht University/NL; H.J. Pel, H. Stam,
C.M.J. Sagt, DSM Biotechnology Center, Delft/NL
9:35 Personalised shRNA libraries - ENTRACE technology for functional screening in
tumours
C. Schmees, H. Volkmer, K.A. Boehme, NMI Natural and Medical Sciences Institute at the
University of Tübingen, Reutlingen
9:55 Essential genes and synthetic lethality in pancreatic cancer
J. Fredebohm, M. Böttcher, J.D. Hoheisel, German Cancer Research Center, Heidelberg
10:15 High-throughput analyses of 80 cancer candidate genes reveals a central role for
Cofilin-1 (CFL1) in regulation of cell proliferation in pancreatic cancer
S. Melchisedech, T. Honstein, R. Kreider, University of Marburg; B. Sipos, J. Sperveslage,
University of Tübingen; T. Gress, M. Buchholz, University of Marburg
10:35 Coffee break and poster viewing
11:05 PLENARE LECTURE
Chair: J.D. Hoheisel, German Cancer Research Center, Heidelberg
High resolution whole genome analysis and cancer
I. Gut, National Genome Analysis Centre, Barcelona/E
Chair: T. Herget, Merck KGaA, Darmstadt
11:50 Monitoring drug effects in preclinical R&D by multiplex indicator protein detection
J. Schache, Merck Millipore, Darmstadt; F. Zenke, Merck Serono, Darmstadt; B. Becher,
T. Herget, C. Koemen, Merck Millipore, Darmstadt; G. Kuehn, Merck Serono, Darmstadt;
S. Kloos, E. Staub, Merck Millipore, Darmstadt; S. Wong, EMD Millipore, Madison, WI/USA;
V. Wuensche, A. Ososipe, T. Henzler, A. Krog, Merck Millipore, Darmstadt
12:10 Profiling of EGFR phosphorylation in Caco-2 gut epithelial cells upon treatment with
proinflammatory cytokines
M. Schmohl, N. Schneiderhan-Marra, NMI Natural and Medical Sciences Institute at the
University of Tübingen, Reutlingen; M. Blum, G. Stein, M. Schmolz, EDI Experimental and
Diagnostic Immunology GmbH, Reutlingen; T.O. Joos, NMI Natural and Medical Sciences
Institute at the University of Tübingen, Reutlingen
12:30 Highly specific activity-based probes for target validation studies of deubiquitinating
enzymes
A. Iphöfer, R. Franke, L. Jänsch, Helmholtz Centre for Infection Research, Braunschweig
12:50 Poster awards
13:00 Closing remarks
13:05 Lunch and end of the conference