(as of 27 November 2012)
10:30 Welcome address
Chair: T.M. Gress, Marburg University Hospital
10:40 Detection and characterization of disease genes in pancreatic cancer through serial
gene expression profiling and parallelized functional assays
S. Melchisedech, T. Honstein, R. Kreider, University Marburg; B. Sipos, J. Sperveslage,
University of Tübingen; N. Giese, University of Heidelberg; T.M. Gress, M. Buchholz,
Marburg University Hospital
11:00 In vivo RNAi screen identifies tumor suppressors in breast cancer
J. Wolf, German Cancer Research Center, Heidelberg; F. Zhang, M.G. Shahmorad,
MD Anderson Cancer Center, Houston, TX/USA; C. Flechtenmacher, University Hospital,
Heidelberg; G. Mills, MD Anderson Cancer Center, Houston, TX/USA; K. Müller-Decker,
J.D. Hoheisel, M. Böttcher, German Cancer Research Center, Heidelberg
11:20 Profiling signal transduction pathways in human tumours: hundreds of "Westerns"
from laser capture dissected samples
F. Treindl, Y. Heubach, NMI Natural and Medical Sciences Institute at University of
Tübingen; S. Schultz, T. Fehm, H. Neubauer, Tübingen University Clinic; M.F. Templin, NMI
Natural and Medical Sciences Institute at University of Tübingen
11:40 Coffee break and poster viewing
Protein Biomarkers
Chair: M. Buchholz, Marburg University Hospital
12:00 Autoantibody signatures of rheumatoid arthritis patients identified with a bead-based
assays approach
H. Goehler, J. Schwermann, M. Gamer, K. Marquardt, A. Telaar, D. Chamrad, C. Theek,
A. Lueking, Protagen AG, Dortmund; J. Fischer, M. Schneider, University Hospital
Düsseldorf; P. Schulz-Knappe, Protagen AG, Dortmund
12:20 Identification of autoantibody biomarkers for prostate cancer screening using protein
microarrays
J. Luna Coronell, M. Gamperl, R. Kulovics, AIT Austrian Institute of Technology GmbH,
Vienna/A; P. Hofer, A. Gsur, Medical University Vienna/A; J. Hofbauer, F. Längle,
Landesklinikum Wiener Neustadt/A; A. Weinhäusel, AIT Austrian Institute of Technology
GmbH, Vienna/A
12:30 Protein biomarker signature for risk classification of ERalpha positive breast cancer
patients identified using reverse phase protein arrays
J. Sonntag, C. Bender, German Cancer Research Center, Heidelberg; S. Aulmann,
University of Heidelberg; S. von der Heyde, M. Nietert, University Medical Center Göttingen;
A. Lier, German Cancer Research Center, Heidelberg; B. Burwinkel, University of
Heidelberg; S. Wiemann, German Cancer Research Center, Heidelberg; T. Beissbarth,
University Medical Center Göttingen; H.P. Sinn, A. Schneeweiss, University of Heidelberg;
U. Korf, German Cancer Research Center, Heidelberg
12:50 Lunch
14:15 PLENARY LECTURE
Chair: T. Herget, Merck KGaA, Darmstadt
Diagnostic reaches pharmacy - treating patients instead of treating diseases
T. Dingermann, Goethe University Frankfurt am Main
Modelling
Chair: T. Herget, Merck KGaA, Darmstadt
15:00 A Boolean model of the cardiac gene regulatory network determining first and second
heart field identity
A. Groß, F. Herrmann, D. Zhou, H.A. Kestler, M. Kühl, Ulm University
15:10 Dynamic multi-scale modeling for individualized spatiotemporal prediction of drug
effects
J. Diaz Ochoa, J. Bucher, J. Niklas, K. Mauch, Insilico Biotechnology AG, Stuttgart
15:30 A model of the DNA damage response (DDR) regulatory network in aging
A. Scheffold, C. Müssel, F. Herrmann, K.L. Rudolph, H.A. Kestler, Ulm University
15:40 Coffee break and poster viewing
16:10 PLENARY LECTURE
Chair: M. Hrabĕ de Angelis, German Research Center for Environmental Health, Munich,
and TU München
System-based biomedicine
R. Balling, Luxembourg Centre for Systems Biomedicine/L
16:55 PANEL DISCUSSION
Personalized medicine - pros and cons
Rudi Balling, Luxembourg Centre for Systems Biomedicine/L
Thomas Gress, Marburg University Hospital
Martin Hrabĕ de Angelis, German Research Center for Environmental Health, Munich, and
TU München (moderation)
Bruce Quinn, Foley Hoag LLP, Boston, MA/USA
18:00 Poster party
20:30 End of the first day
Tools
Chair: T. Joos, NMI Natural and Medical Sciences Institute, Reutlingen
09:30 Improving the biomarker validation by a cross-platform comparison
K. Köhler, H. Seitz, Fraunhofer Instiute for Biomedical Engineering, Potsdam
09:40 Impedance sensing in trans-well chambers shows metastasis promoting potential of
mesenchymal stem cells
F. Graf, German Cancer Research Center & Mannheim University of Applied Sciences,
Heidelberg; M. Boutros, German Cancer Research Center & Heidelberg University;
C. Maercker, Mannheim University of Applied Sciences & German Cancer Research
Center Heidelberg
09:50 Technical realization of a new synthetic bio production system generating human
tumor specific targeted cytokines in personalized medicine
N. Klehr, L. Bauer, H. Focke, B. Brüderl, J. Setter, Dr. Klehr Institut für Immunologie und
Zellbiologie, Munich
10:00 High throughput in vitro antibody generation for gene function analysis
S. Dübel, Technische Universität Braunschweig
10:20 Coffee break and poster viewing
Protein Microarrays
Chair: J.D. Hoheisel, German Cancer Research Center, Heidelberg
10:50 On demand protein arrays for personalised proteomics - a progress report
R. Schmidt, D. Kastelic, E. Cook, M.J. Taussig, O. Stoevesandt, Babraham Institute,
Cambridge/UK
11:00 Creating protein patterns with light by maskless projection lithography
B. Waterkotte, A. Waldbaur, B.E. Rapp, Karlsruhe Institute of Technology, Eggenstein-
Leopoldshafen; K. Schmitz, Technical University of Darmstadt
11:10 Pitfalls and payoffs in relative protein quantification using protein microarrays
R. Wellhausen, H. Seitz, Fraunhofer Institute for Biomedical Engineering IBMT,
Potsdam-Golm
11:20 Antibody microarray proteomics of pancreatic cancer cells under the effect of stromal
secretory mediators
A. Yildirim, A. Marzoq, M.S.S. Alhamdani, J.D. Hoheisel, German Cancer Research Center,
Heidelberg
11:30 PLENARY LECTURE
Chair: T. Joos, NMI Natural and Medical Sciences Institute, Reutlingen
Genomic tests: the impact of pharmacoeconomic and comparative effectiveness
studies on adoption
B. Quinn, Foley Hoag LLP, Boston, MA/USA
12:15 Poster Prizes
12:30 Closing remarks
12:35 Lunch and end of the conference