Scale-up and scale-down of bioprocesses

Poster Programme

P 1

Effects of fermentation scales on biomass development and yeast cell viability under beer fermentation conditions
X. Zhao, S. Procopio, T. Becker, TU München, Freising/D

P 2

INOSIM process: simulation based scale-up of bioprocesses
K. Sulzbacher, INOSIM Consulting GmbH, Dortmund/D; G. Schembecker, TU Dortmund/D

P 3

Development of a new training simulator for bio-ethanol plants and its application for ressource efficiency studies
V. Hass, Hochschule Furtwangen, Villingen-Schwenningen/D; S. Kuntzsch, Hochschule Bremen/D; K.-M. Schoop, Ingenieurbüro Schoop GmbH, Hamburg/D; M. Winterhalter, Universität Bremen/D; R. Pörtner, TU Hamburg-Harburg/D

P 4

Multiple and directed integration of recombinant protein expression cassettes into the genome of Pichia pastoris
J-P. Schwarzhans, D. Wibberg, J. Kalinowski, K. Friehs, Universität Bielefeld/D

P 5

Oligosaccharide synthesis by use of ß-galactosidase in a variety of organic solvents and a ionic liquid
R. Brakowski, K. Pontius, J. Hübner, M. Franzreb, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen/D

P 6

Enzymatic carboxylation of phenolics utilizing CO2 as starting material
L. Pesci, P. Gurikov, I. Smirnova, TU Hamburg-Harburg/D; K. Faber, University of Graz/A; A. Liese, TU Hamburg-Harburg/D

P 7

Specific power input in orbitally shaken bag bioreactors: an engineering parameter for scale-up and scale-down
S. Werner, D. Eibl, Zurich University of Applied Sciences, Wädenswil/CH

P 8

Parallel cultivation of microorganisms using bench scale and small scale rigid-wall single-use bioreactors
S. Kleebank, DASGIP GmbH, Jülich/D; A. Niehus, Eppendorf AG, Jülich/D

P 9

Characterization of an E.coli production process using a scale down model
K. Miehe, N. Zagler, D. Hädicke, S. Martens, T. Kaiser, B. Krampe, H. Tebbe, Roche Diagnostics GmbH, Penzberg/D

P 10

Scale-down of a HGMS filter unit for lab scale implementation of separation and reaction procedures in integrated processes
H. Al-Kaidy, R. Ulber, N. Tippkötter, TU Kaiserslautern/D

P 11

An automated magnetic platform for controlled enzymatic reactions of lab-in-a-drop systems
H. Al-Kaidy, R. Ulber, N. Tippkötter, TU Kaiserslautern/D

P 12

Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas, M. Schaletzky, R. Pörtner, TU Hamburg-Harburg/D; B. Frahm, Hochschule Ostwestfalen-Lippe, Lemgo/D; V. Sandig, ProBioGen AG, Berlin/D

P 13

Metabolic engineering of Corynebacterium glutamicum for increasing lysine production using a lysine riboswitch
L.B. Zhou, R.R. Bommareddy, A.P. Zeng, TU Hamburg-Harburg/D

P 14

Characterization of continuous nisin-production by Lactococcus lactis biofilms on microstructured surfaces
M. Huster, C. Schlegel, R. Ulber, TU Kaiserslautern/D

P 15

Automated small-scale enzymatic membrane reactor: design, control and its applications
A. Sitanggang, TU Berlin/D; A. Drews, Hochschule für Technik und Wirtschaft Berlin/D; M. Kraume, TU Berlin/D

P 16

The cell cycle as a process parameter in mammalian cell culture
G. Fuge, TU Hamburg-Harburg/D; K. Riecken, Universitätsklinikum Hamburg-Eppendorf/D; A. E. Castillo, U. Jandt, A. P. Zeng, TU Hamburg-Harburg/D

P 17

Production of the antibody fragment D1.3scFv in Bacillus sp.
A. Lakowitz, R. Biedendieck, R. Krull, TU Braunschweig/D

P 18

In situ purification of his-tagged products using functionalized super paramagnetic iron oxide nanoparticles in Bacillus megaterium
J. Gädke, R. Biedendieck, R. Krull, TU Braunschweig/D

P 19

Production of high value food products by fermentation of biogenic waste streams
N. Wolters, G. Schembecker, J. Merz, TU Dortmund/D

P 20

Production of recombinant proteins with E. coli from shake flask to industrial scale
K. Friehs, R.S. Velur Selvamani, M. Telaar, E. Flaschel, Bielefeld University/D

P 21

Effective L-tryptophan production in Escherichia coli created by rational and integrative molecular engineering
L. Chen, A.P. Zeng, TU Hamburg-Harburg/D

P 22

Production of fusicoccadiene by Saccharomyces cerevisiae
L. Halka, M. Freder, R. Wichmann, TU Dortmund/D

P 23

Gas-fermentation with Acetobacterium woodii in a membrane reactor
C. Kantzow, A. Mayer, D. Weuster-Botz, TU München, Garching b. München/D

P 24

Scale-up / scale-down studies of fermentation processes with Komagataella pastoris
A. Schmideder, TU München, Garching b. München/D; A. Stratmann, W42 Industrial Biotechnology GmbH, Marl/D; D. Weuster-Botz, TU München, Garching b. München/D

P 25

Tunable aqueous polymer-phase impregnated resins-technology - a technology for downstream processing of biomolecules
I. Kaplanow, G. Schembecker, J. Merz, TU Dortmund/D

P 26

3D-printed individual labware in biosciences by rapid prototyping
T. Lücking, F. Sambale, D. Bulnes-Abundis, C. Busse, S. Beutel, T. Scheper, Universität Hannover/D

P 27

Inertial based fast media exchange in a microfluidic spiral cell separator for metabolomic analysis of microorganisms
E. Hans, S. Bohne, A.-P. Zeng, TU Hamburg-Harburg/D

P 28

iHCDC - improved high cell-density cultivation process for E. coli
E. Sanders, B. Beckmann, S. Kaul, P. Derr, Hochschule für Angewandte Wissenschaften Hamburg/D

P 29

New perspectives in shake flask monitoring using a multisensory platform for scale up process improvement
C. Ude, Universität Hannover/D; M. Findeis, G.T. John, PreSens Precision Sensing GmbH, Regensburg/D; T. Scheper, S. Beutel, Universität Hannover/D

P 30

New high capacity chromatography resins for antibody purification
M. Frhr. v. Roman, S. Berensmeier, TU München, Garching b. München/D

P 31

Bench-top lab automation systems for a faster scale up of bioprocesses - current solutions and future prospects
F. Lenk, M. Vogel, C. Otto, P. Labudde, P. Oberthür, T. Bley, E. Boschke, TU Dresden/D

P 32

100 years of fed-batch technology - scaling experiences and implications for further developments
P. Neubauer, S. Junne, TU Berlin/D

P 33

Quasi-continuous bioprocessing with Pichia pastoris - scale-up productivity in a scale-down production plant
S.-O. Borchert, F. Aupert, M. Huettemann, S. Weyand, C. Kober, R. Luttmann, TU Hamburg-Harburg/D

P 34

Systems biology approach for determining the physiology of an oleaginous yeast
R.R. Bommareddy, W. Sabra, A.P. Zeng, TU Hamburg-Harburg/D

P 35

Multiscale cytokine purification using membrane chromatography
G. Brockmeier, I. Pepelanova, S. Beutel, U. Rinas, Universität Hannover/D; L. Villain, Sartorius Stedim Biotech GmbH, Göttingen/D; T. Scheper, Universität Hannover/D

P 36

Scale down of bioprocesses - the "pipe based bioreactors" concept
G. Gastrock, Institut für Bioprozess- und Analysenmesstechnik e.V., Heilbad Heiligenstadt/D

P 37

Enzymatic production of acetylated cello-oligomers from water-soluble cellulose acetate
S. Kluge, A.C. Spiess, RWTH Aachen/D

P 38

Scale-up of fermentative lactic acid production from renewable feedstocks
D. Pleissner, Leibniz-Institute for Agricultural Engineering, Potsdam/D; J. Venus, Leibniz-Institute of Agricultural Engineering, Potsdam/D

P 39

Scalability of marine cultivations of the heterotrophic algae Crypthecodinium cohnii in single-use bioreactors
A. Marbà-Ardébol, F. Hillig, O. Zakrzewski, TU Berlin/D; J. Emmerich, SOPAT GmbH, Berlin/D; P. Neubauer, S. Junne, TU Berlin/D

P 40

The importance of local mass transfer phenomena in scale-up processes
S. Heithoff, N. Räbiger, Universität Bremen/D

P 41

Seamless scale-up of an antibody upstream process from early process development to 2500L pilot scale supported by PAT
J. Dietrich, Bayer Healthcare Pharma, Wuppertal/D; C. Knappe, Bayer Technology Services GmbH, Leverkusen/D; T. Thuete, Bayer Healthcare Pharma, Wuppertal/D; J. Traenkle, Bayer Technology Services GmbH, Leverkusen/D; A. Jockwer, Bayer Healthcare Pharma, Wuppertal/D

P 42

Decision tree for selection of suitable cultivation parameters for mammalian cell culture processes
R. Pörtner, S. Kern, TU Hamburg-Harburg, Hamburg/D; D. Eibl, Zürcher Hochschule für Angewandte Wissenschaften, Wädenswil/CH

P 43

Novel two compartment setup enables faster scale-up study: a tribute to the robustness of C. glutamicum
M. Limberg, T. Aryani, W. Wiechert, M. Oldiges, Forschungszentrum Jülich GmbH/D

P 44

Scale-down approach: tools for the understanding of cellulase production for 2G-bioethanol
N. Hardy, IFP Energies nouvelles, Rueil-Malmaison/F; C. Béal, UMR 782 AgroParisTech INRA, Thiverval-Grignon/F; F. Augier, H. Gonzalez Penas, M. Moreaud, IFP Energies nouvelles, Solaize/F; F. Ben Chaabane, IFP Energies nouvelles, Rueil-Malmaison/F; A. W. Nienow, University of Birmingham/UK

P 45

Bioprocess automation for fast microbial strain selection and detailed quantitative phenotyping
A. Radek, S. Unthan, M. Oldiges, S. Noack, Forschungszentrum Jülich GmbH/D

P 46

5-Hydroxytryptophan and serotonin production by synthetic pathways of engineered Escherichia coli strains
J.A. Mora-Villalobos, TU Hamburg-Harburg/D

P 47

On-line monitoring and control of a production process with Pichia pastoris based on spectroscopic measurements and MVDA
J.-P. Voss, N.E. Mittelheuser, R. Lemke, J. Hirsch, R. Luttmann, Hochschule für Angewandte Wissenschaften Hamburg/D

P 48

Simulating large scale conditions in a scale-down bioreactor: impacts on cell physiology of recombinant Escherichia coli
C. Reitz, L. Ping, S. Junne, P. Neubauer, TU Berlin/D

P 49

Scale up and scale down of truly continuous bioprocesses
K. Bühler, R. Karande, B. Halan, A. Schmid, Helmholtz Zentrum für Umweltforschung UFZ, Leipzig/D

P 50

In silico scale-down/scale-up of column liquid chromatography using a generalized porous media equation
T. Hahn, T.C. Huuk, Karlsruhe Institute of Technology (KIT), Karlsruhe/D; V. Heuveline, Universität Heidelberg/D; J. Hubbuch, Karlsruhe Institute of Technology (KIT), Karlsruhe/D

P 51

Implementation of an alternative concept for process integration in USP and DSP of antibody manufacturing
P. Gronemeyer, R. Ditz, J. Strube, TU Clausthal/D

P 52

Internal illumination of a 15 L - airlift photobioreactor via wireless light emitters
M. Heining, A. Sutor, R. Buchholz, Universität Erlangen-Nürnberg/D

P 53

In situ reactive extraction of itaconic acid from Aspergillus terreus fermentation broth
D. Kreyenschulte, R. Kossack, L. Regestein, J. Büchs, RWTH Aachen/D

P 54

Scalability of mechanistic models for ion exchange chromatography
T. Huuk, T. Hahn, Karlsruhe Institute of Technology (KIT)/D; J. Griesbach, S. Hepbildikler, Roche Diagnostics GmbH, Penzberg/D; J. Hubbuch, Karlsruhe Institute of Technology (KIT)/D

P 55

Basidiomycetous enzymes for flavour transformation reactions
B. Fuchs, V. Esparan, U. Krings, R.G. Berger, Universität Hannover/D

P 56

A multi-fixed-bed fermenter system as a powerful tool for bioprocess development applied for immobilized lactic acid bacteria
R. Faschian, S. De, TU Hamburg-Harburg/D; C. Zenneck, medorex e.K., Nörten-Hardenberg/D; R. Pörtner, TU Hamburg-Harburg/D

P 57

Bioactive metabolites from Myxobacetria - process characterization and development towards increased productivity
A. Beckmann, S. Bernecker, K. Bohle, M. Stadler, Helmholtz Centre for Infection Research, Braunschweig/D

P 58

Perspectives for the production of ethyl acetate by yeasts based on renewable raw material
C. Löser, TU Dresden/D; T. Urit, Nakhon Sawan Rajabhat University/T; T. Bley, TU Dresden/D

P 59

Model-based scale-up in membrane chromatography
P. Ghosh, E. Velali, E. von Lieres, Forschungszentrum Jüllich GmbH/D

P 60

Die Zentrifugalverteilungschromatographie als Reaktor zur enzymatischen Hydrolyse in wässrig/organischen Zweiphasensystemen
J. Krause, G. Schembecker, J. Merz, TU Dortmund/D

P 61

Miniaturization of purification strategies for systematic downstream process development
F. Thygs, J. Merz, G. Schembecker, TU Dortmund/D

P 63

Production of the tryptophan based antibiotic rebeccamycin
J. Blotenberg, R. Krull, TU Braunschweig/D

P 64

Considerations for cell passaging in cell culture seed trains
T. Hernández Rodríguez, Ostwestfalen-Lippe University of Applied Sciences, Lemgo/D; R. Pörtner, TU Hamburg-Harburg/D; B. Frahm, Ostwestfalen-Lippe University of Applied Sciences, Lemgo/D

P 65

Making predictions for systems metabolic engineering of E. coli using a "real cell" model
L. Song, A.P. Zeng, TU Hamburg-Harburg/D

P 66

Optimization of AMDase catalyzed profene synthesis
M. Aßmann, TU Hamburg-Harburg/D; S. Gaßmeyer, R. Kourist, Ruhr-Universität Bochum/D; A. Liese, TU Hamburg-Harburg/D

P 67

Fast transcriptional responses of Corynebacterium glutamicum facing CO2 gradients
M. Graf, Universität Stuttgart/D; J. Buchholz, Universität Stuttgart/D and Sandoz GmbH, Kundl/A; A. Freund, T. Busche, J. Kalinowski, Center for Biotechnology (CeBiTec), Bielefeld/D; B. Blombach, R. Takors, Universität Stuttgart/D

P 68

Rational design of riboswitch with expanded response range of small molecules for metabolic flux control
C. Ma, L. Zhou, A.-P. Zeng, TU Hamburg-Harburg/D

P 69

Manipulation of multi-enzyme complex: computational and experimental analyses of structure and function
U. Jandt, S. Hezaveh, J. Guo, A.P. Zeng, TU Hamburg-Harburg/D

P 70

Transcription profiling of scale-up dependent regulatory phenomena
J. Simen, M. Löffler, A. Freund, Universität Stuttgart/D; G. Jäger, Universität Tübingen/D; R. Takors, Universität Stuttgart/D

P 71

Modelling of local behavior of the gas phase in stirred tank bioreactors with CFD: an Euler-Lagrange approach for scale-up predictions
J. Wutz, A. Lapin, Universität Stuttgart/D; M. Berger, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss/D; R. Takors, Universität Stuttgart/D

P 72

Electricity driven synthesis in bioreactors: upgrading conventional infrastructure
C. Stang, L. Rosa, S. Hunger, C. Gimkiewicz, T.R. dos Santos, A. Zehnsdorf, F. Harnisch, Helmholtz Centre for Environmental Research, Leipzig/D

P 73

Improved method for the screening and sizing of depth and sterile filters in-line
M. Hannappel, Merck Chemicals GmbH - Merck Millipore, Schwalbach/D

P 74

Modeling mass transfer in small scale reactors using Computational Fluid Dynamics
H. Larsson, K. V. Gernaey, U. Krühne, Technical University of Denmark/DK

P 75

The trail to the industrial scale
S. Briechle, M. –H. Kopf, S. Freyer, BASF SE, Ludwigshafen/D

P 76

Scale up of a Salvia suspension culture from shake flask to bioreactor systems of several litres
C. Haas, HTW Dresden/D and TU Dresden/D; Mario Opitz, HTW Dresden/D; Thomas Bley, TU Dresden/D; Jörg-Uwe Ackermann, HTW Dresden/D

P 77

Transient physiologic states: friend or foe?
W.N. Reichelt, M. Brillmann, P. Thurrold, C. Herwig, Vienna University of Technology/A

P 78

Natural elicitors enhancing triterpene production
S. Kümmritz, M. Louis, S. Gantz, H. Delenk, TU Dresden/D; C. Haas, TU Dresden/D and Hochschule für Technik und Wirtschaft Dresden/D; T. Bley, J. Steingoewer, TU Dresden/D

P 79

BioSpeckle: development of a non-invasive sensor for determination of biomass in biotechnological processes by Laser-Speckle-Photometry
C. Schott, T. Bley, J. Steingroewer, TU Dresden/D; B. Bendjus, U. Cikalova, Fraunhofer IKTS/D; T. Werner, Werner industrial electronics, Kreischa/D

P 80

Determination of the volumetric mass transfer coefficient (kLa) using the dynamic Na2SO3-method: Analysis with offgas-sensors
D.Bittner, Westfälische Hochschule Recklinghausen/D; H. Müller, Blue Sens gas sensor GmbH, Herten/D; F. Eiden, Westfälische Hochschule Recklinghausen/D

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