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Channeling of substrates, metabolites and products is a crucial issue in any biotech process. In this workshop, the latest developments regarding transport processes in enzymatic or microbial systems will be presented and discussed.
So far industrial biotechnology research has focused mainly on the development of new production methods: Screening and optimization of enzymes with new functions, their expression and the construction of new metabolic pathways as well as their regulation are familiar challenges in this field of research.
In recent years, it has become evident that there are other fields where bioengineering can contribute: The channeling of molecules is crucial for the development of any industrial process. Today we know channels and loop areas of enzymes as starting points for the optimization of enzymes. They allow to control toxic compounds and metabolic traffic. However, channeling is not limited to the transport of substrates, metabolites and products to and from the catalytic centers of enzymes, but also relevant within synthesis particles or microorganisms. When consortia come into play, the targeted transport of molecules between individual cells or different microorganisms is essential. Synthesis vesicles and protein cages are but one approach to this challenge. The understanding of intra- and intercellular transport phenomena opens up new opportunities for the optimization and design of biotechnological production systems. Computer simulations help to reduce the lab work and gain new insights.
In this workshop, new developments will be presented and we discuss whether we can expect these new systems and their control to contribute to a more efficient development in both enzyme engineering and metabolic engineering.
| 09:00 | Registration |
|---|---|
| 10:00 | Opening B. Hauer, University of Stuttgart/D |
| 10:10 | A light at the end of the tunnel: Possibilities of enzyme engineering beyond the active site L. Rapp, BASF SE, Ludwigshafen/D |
| 10:40 | Title tba M. Warren, Quadram Institute Bioscience, Norwich/UK |
| 11:10 | Coffee break |
| 11:30 | Compartmentalization & de novo organelles as platform for channeling effects - new paradigms for biocatalysis in biotechnology?
S. Schiller, Albert Ludwig University of Freiburg/D |
| 12:00 | Visualization of the gene expression hardware for m-xylene degradation of P. putida mt-2
V. de Lorenzo, National Center for Biotechnology, Madrid/E |
| 12:30 | Lunch break |
| 14:00 |
Artificial transport metabolons: bringing together sugar transport and metabolism M. Oreb, Goethe University Frankfurt/D |
| 14:30 |
Production of biochemicals using bacterial consortia A. Toftgaard Nielsen, Technical University of Denmark, Lyngby/DK |
| 15:00 |
The impact of transport phenomena on translation and metabolism in E. coli R. Takors, University of Stuttgart/D |
| 15:30 |
Resumé / Discussion B. Hauer, University of Stuttgart/D |
| 15:45 |
End of Workshop |
DECHEMA-Haus
Theodor-Heuss-Allee 25
D-60486 Frankfurt/Main
Germany
Directions to DECHEMA: Please find a detailed description at www.dechema.de/location.
Parking capacities at DECHEMA are limited. Please also use public parking lots along Theodor-Heuss-Allee: Congress-Center-Messe (CMF) or at the fair tower (Messeturm).
We recommend the following hotels. We have not reserved any contingent of rooms. Please book a room by yourself. When using the booking code you will get a special rate.
Mercure Hotel (10 min walking distance)
Voltastr. 29
60486 Frankfurt am Main
Phone: +49 69 7926 2709
E-Mail:
Single room: 107 EUR per night and incl. breakfast and wifi.
You can book your rooms directly with the booking code "DECHEMA".
HOTEL FRANKFURT MESSE managed by Meliá Hotels International
Katharinenkreisel (Opelrondell)
60486 Frankfurt am Main
Tel.: 707 30 500, Fax: 707 30 333
Single room: 85 EUR per night and incl. breakfast and wifi.
Trade fair rate: 185 EUR
You can book your rooms directly with the booking code "DECHEMA".
Motel One Frankfurt-Messe
Europa-Allee 25
60327 Frankfurt
Single room: 92,50 EUR per night (rate during trade fair to be requested) and incl. breakfast and wifi.
You can book your rooms directly with the booking code "DECHEMA".
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Image source: Universität Stuttgart, IBTB, Abt. Technische Biochemie
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