(subject to change, as of 30 April 2021)
Wednesday, 5 May 2021
| 10:00 |
Opening and Technical Remarks |
|---|---|
Synthetic Biology, Screening Platforms and Metabolomics
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| 10:10 |
Keynote Lecture 1
Toward a world of ElectroGeneticsM. Fussenegger¹; ¹ ETH Zurich/CH |
| 10:40 | Advanced in vitro management of three-dimensional cell cultures and explanted tissue S. Kreß¹; D. Egger¹; C. Kasper¹ ¹ University of Natural Resources and Life Sciences (BOKU), Vienna/A |
| 10:55 |
Label-free measurements of the metabolic activity within 3D cell culture model via automated 3D microphysiometry |
| 11:10 |
P2.2.04 Hypoxia or normoxia: mesenchymal stem cells and chondrocytes with a genetically integrated hypoxia sensor in different 3D cell culture systems |
| 11:15 |
EU-OPENSCREEN: A novel collaborative model for accelerating early phase drug discovery |
| 11:30 | Discussion with all speakers of this session |
| 11:45 | Lunch Break |
Advanced 3D Models for Tumor ResearchChair: J.M. Kelm, PreComb Therapeutics AG, Wädenswil/CH |
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| 13:30 |
Keynote Lecture 2
Organotypic 3D models to characterize the molecular requirements of immune cell infiltration and activationW. Sommergruber¹; A. Osswald²; I. Voelkl³; V. Hedrich³; A. Rudisch³; N. Harrer³; M. Dong⁴; H. van der Kuip⁴; A. Wernitznig³; A. Bernthaler³; J. Lipp³; S. Rebelo⁵; C. Pinto³; C. Brito⁵; S. Hall⁶ ¹ University of Applied Sciences Vienna/A; ² Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/D; ³ Boehringer Ingelheim RCV GmbH & Co KG, Vienna/A; ⁴ University of Tuebingen/D; ⁵ iBET, Universidede Nova de Lisboa/P; ⁶ University Hospital Bern/CH |
| 14:00 |
Development of a 4D-in vitro-test system for specificity and potency of 3rd generation chimeric antigen receptor-T-cells (CAR-T-cells) based on microcavity array-bioreactors ² University Hospital Heidelberg/D |
| 14:15 |
3D modelling of the chronic lymphocytic leukaemia microenvironment |
| 14:30 | Targeting the fibrotic tumor microenvironment: Novel 3D co-culture organoids for pancreatic adenocarcinoma (PDAC) drug discovery J. Hänsel¹; K. Peter¹; T. Kurz²; R. Mrsny³; N. Teusch¹ ¹ Universität Osnabrück/D; ² Heinrich-Heine-Universität Düsseldorf/D; ³ University of Bath/UK |
| 14:45 |
P3.3.01 Generation of multicellular spheroid culture models of pediatric vital tumor samples obtained through the INFORM registry study for functional studies |
| 14:50 | Discussion with all speakers of this session |
| 15:05 |
Poster Session 1 / Exhibition |
| 16:45 |
End of Day 1 |
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17:00 -18:00 |
Section Member Assembly DECHEMA Sections "Cell Culture Technology" and "Medical Biotechnology" |
Complex and Multi-Celltype ModelsChair: C. Kasper, University of Natural Resources and Life Sciences, Vienna/A |
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| 09:00 |
Image based quantification of myeloid cell repolarization and their interplay within the tumor microenvironment in 3D |
| 09:15 | Application of ultrasmall gold nanoparticles (2 nm) in a 3D blood-brain-barrier in vitro model V. Sokolova¹; G. Mekky²; S. van der Meer¹; M. Seeds³; A. Atala³; M. Epple¹ ¹ University of Duisburg-Essen, Essen/D; ² Zagazig University/ET; ³ Wake Forest School of Medicine, Winston-Salem, NC/USA |
| 09:30 |
Manufacturing of functional beta cell-mesenchymal stem cell-spheroids for transplantation or drug testing ² University of Giessen/D |
| 09:45 | Assembly of multi-spheroid cellular architectures by programmable droplet merging H. Cui¹; A. Popova¹; P. Levkin¹ ¹ Karlsruher Institut für Technologie (KIT), Eggenstein-Leopoldshafen/D |
| 10:00 |
P1.2.01 Development of a new human organotypic 3D urinary bladder epithelium model in complex whole blood co-culture with immune cells |
| 10:05 |
Discussion with all speakers of this session |
| 10:20 |
Coffee Break |
Innovative Microphysiological Systems IChair: U. Marx, TissUse GmbH, Berlin/D |
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| 11:00 |
Keynote Lecture 3
Application of microphysiological systems to drug safety assessment: progress and challengesR. David¹; ¹ AstraZeneca, Cambridge/UK |
| 11:30 | OncoChip - A novel microfluidic platform for compound efficacy testing on human 3D microtumors M. Pawlak¹; S. Yüz²; B. Gierke¹; J. Hofmann³; U. Härle²; S. Werner²; B. Hagmeyer²; Z. von Guttenberg³; M. Stelzle²; C. Schmees² ¹ NMI TT Pharmaservices, Reutlingen/D; ² NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen/D; ³ ibidi GmbH, Gräfelfing/D |
| 11:45 |
P2.1.02 Applying a microphysiological 3D human liver – islet microtissue platform to study drug – drug interaction |
| 11:50 |
P1.1.07 |
| 11:55 |
Discussion with all speakers of this session |
| 12:10 |
Lunch Break |
| 13:30 |
Poster Session 2 / exhibition |
Innovative microphysiological systems IIChair: J. Hansmann, Universitätsklinikum Würzburg/D |
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| 15:00 |
Keynote Lecture 4
Advancing regulatory science through innovation; in vitro microphysiological systemsS. Fitzpatrick¹ ¹ Center for Food Safety and Applied Nutrition / FDA, College Park, MD/USA |
| 15:30 | A human immuno-competent microphysiological alveolus-on-chip model to study microbial pathogenesis K. Rennert¹; S. Deinhardt-Emmer²; E. Schicke²; Z. Cseresnyés³; S. Nietzsche²; M. Raasch¹; G. Makert dos Santos⁴; S. Ulbert⁴; P. Loskill⁵; C. Ehrhardt²; B. Löffler²; A. Mosig² ¹ Dynamic42 GmbH, Jena/D; ² University Hospital Jena/D; ³ Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena/D; ⁴ Fraunhofer Institute for Cell Therapy and Immunology, Leipzig/D; ⁵ Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart/D |
| 15:45 | Micro-physiological system for prolonged cultivation of immune competent lung tissue ex vivo S. Böhlen¹; S. Konzok¹; S. Behrens²; F. Schmieder²; F. Sonntag²; A. Braun¹; S. Dehmel¹; K. Sewald¹ ¹ Fraunhofer Institute for Toxicology and Experimental Medicine ITEM & Biomedical Research in Endstage and Obstructive Lung Disease Hanover (BREATH), Hanover/D; ² Fraunhofer Institute for Material and Beam Technology IWS Dresden/D |
| 16:00 |
P3.1.01 Development of vascularized melanoma skin equivalents for studying metastasis and anti-melanoma therapies |
| 16:05 |
Discussion with all speakers of this session |
| 16:20 |
Award Ceremony
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| 16:45 |
Virtual Get Together at "wonder"
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| 18:00 |
End of Day 2 |
Investigating Host-Microbial InteractionsChair: I. Prade, Forschungsinstitut für Leder und Kunststoffbahnen (FILK) gGmbH, Freiberg/D |
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| 09:00 | Microengineered in vitro model of the small intestine epithelium for studying host-bacteria interactions M. García-Díaz¹; M. Cendra¹; R. Alonso-Román¹; E. Torrents¹; E. Martínez¹ ¹ Institute for Bioengineering of Catalonia (IBEC), Barcelona/E |
| 09:15 | Matrix-free culture of intestinal organoids in thermoformed microwells P. Kakni¹; S. Giselbrecht¹; R. Truckenmüller¹; P. Habibovic¹ ¹ Maastricht University/NL |
| 09:30 | Investigating human cytomegalovirus infection in human vessels based on novel in vitro and in vivo model systems A. Dittrich¹; I. Kutle¹; D. Wirth¹ ¹ Helmholtz Centre for Infection Research, Braunschweig/D |
| 09:45 |
Discussion with all speakers of this session |
| 10:00 |
Coffee Break |
Bioprinting and Enabling TechnologiesChair: M. Rimann, Zurich University of Applied Sciences, Wädenswil/CH |
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| 10:30 | Fabrication of human jawbone models using stereolithographic 3D bioprinting A. Amler¹; A. Thomas¹; T. Lam²; M. Geiger²; A. Kreuder¹; C. Palmer²; S. Nahles³; R. Lauster¹; L. Kloke² ¹ TU Berlin/D; ² Cellbricks GmbH, Berlin/D; ³ Charite Universitätsmedizin Berlin/D |
| 10:45 | Drop-on-demand bioprinting solutions for the fabrication of 3D cell culture systems aiming for in vitro screening applications K. Tröndle¹; A. Itani¹; F. Koch¹; R. Zengerle²; P. Koltay¹; S. Zimmermann¹ ¹ University of Freiburg/D; ² Hahn-Schickard, Freiburg/D |
| 11:00 | Using peptide hydrogels to build 3D cell disease and tissue models for drug discovery A. Miller¹; ¹ University of Manchester/UK |
| 11:15 | Discussion with all speakers of this session |
| 11:30 | Closing Remarks |
| 11:35 | End of the Conference |
