(subject to change)
Wednesday, 25 June 2014
Thursday, 26 June 2014
Friday, 27 June 2014
Top
11:00 Welcome
Prediction in cancer research
Chair T. Noll, University of Bielefeld/D
11:05 Keynote Lecture
IMI PREDECT: Characterising 3D models for target validation in cancer
J.A. Hickman, Institut de Recherches Servier, Paris/F
11:50 Identification of genetic determinants for tumor spheroid morphology and drug
sensitivity
M.C. Park, S. Kim, Seoul National University/ROK
12:10 Predicting clinical therapeutic response in primary ovarian cancer using human
cancer tissue-originated spheroids
O. Hoffmann, Spherotec GmbH, Martinsried/D; R. Loewe, GeneWake GmbH, Munich/D;
D. Beer, University Hospital LMU, Munich/D; H. Jansen, University Hospital TUM,
Munich/D; B. Mayer, Spherotec GmbH, Martinsried/D
12:30 A combined in silico and in vitro lung cancer model on a decellularized matrix for
individualized drug response predictions
A.T. Stratmann, D. Fecher, University Hospital of Würzburg/D; G. Wangorsch,
University of Würzburg/D; C. Göttlich, T. Walles, H. Walles, University Hospital of
Würzburg/D; T. Dandekar, University of Würzburg/D; G. Dandekar, S.L. Nietzer,
University Hospital of Würzburg/D
12:50 Lunch
Assessment of drug safety and toxicity
Chair J. Kelm, InSphero AG, Schlieren/CH
14:15 Keynote Lecture
Application of 3-dimensional co-culture models in drug safety assessment
A.B. Roth, Hoffmann-La Roche AG, Basel/CH
15:00 Enabling in vivo relevant drug toxicity testing in organ like cell culture models
J. Schütte, S. Werner, S. Hajek, NMI Natural and Medical Sciences Institute, Reutlingen/D;
J. Böttger, R. Gebhardt, University Leipzig/D; S. Maier, D. Stoll, M. Stelzle, NMI Natural and
Medical Sciences Institute, Reutlingen/D
15:20 Validation of in vitro cell health assays for 3D microtissues
T.L. Riss, M.P. Valley, C.A. Zimprich, K.R. Kupcho, D.F. Lazar, Promega Corporation,
Madison, WI/USA
15:40 New 3D cell model as an alternative for animal testing in osteoarthritis research
I. Ponomarev, fzmb GmbH, Bad Langensalza/D; A. Lang, BSRT / Charité, Berlin/D;
T. Reuter, fzmb GmbH, Bad Langensalza/D
15:50 A multifunctional device for automated 3D-cultivation of hepatocytes and monitoring
of drug toxicity based on a novel flow-through ELISA
D. Kuersten, M. Baca, J. Hampl, U. Fernekorn, M. Klett, A. Läffert, K. Friedel, A. Schober,
Ilmenau University of Technology/D
16:00 Coffee Break
Compound screening and profiling
Chair C. Burger, Merck KGaA, Darmstadt/D
16:30 Keynote Lecture
Ultra-high content analysis of 3D cell cultures for compound screening and profiling
L. Price, OcellO B.V., Leiden/NL
17:15 3D microtissues for the discovery of chemoradiation-sensitizing compounds
N. Anastasov, I. Hoefig, V. Radulovic, Helmholtz Zentrum München, Neuherberg/D;
S. Stroebel, InSphero AG, Schlieren/CH; C. Thirion, Sirion Biotech GmbH, Martinsried/D;
J. Lichtenberg, J. Kelm, InSphero AG, Schlieren/CH; J.M. Atkinson, Helmholtz Zentrum
München, Neuherberg/D
17:35 Microfluidic 3D cell culture platform for high-throughput drug screening
S. Trietsch, MIMETAS B.V., Leiden/NL; V. van Duinen, Leiden University/NL; J. Joore,
MIMETAS B.V., Leiden/NL; T. Hankemeier, Leiden University/NL; P. Vulto, MIMETAS B.V.,
Leiden/NL
17:55 Multiplexing resazurin reduction, spheroid volume and acid phosphatase assays
for spheroid viability in high-throughput
D.P. Ivanov, T. Parker, D. Walker, C. Alexander, M.C. Garnett, University of Nottingham/UK;
M. Ashford, P. Gellert, AstraZeneca, Macclesfield/UK
18:15 Human organotypic test models for functional, immuno-pharmacological drug
screening
M. Schmolz, EDI GmbH, Reutlingen/D
18:25 End of Lecture Programme of Day 1
18:30-19:30 Section Member Assembly
18:30-21:00 Poster Session / Poster Party
Disease models
Chair T. May, InSCREENeX GmbH, Braunschweig/D
09:00 Keynote Lecture
3D biopatterning technologies to engineer model systems for cancer and neural
microenvironment
U. Demirci, S. Guven, Harvard Medical School, Cambridge, MA/USA
09:45 Studying gene function analysis in 3D tumor microtissue models
S. Stroebel, InSphero AG, Schlieren/CH; C.R. Thoma, N. Rösch, B. Calpe, W. Krek,
ETH Zurich/CH; J.M. Kelm, InSphero AG, Schlieren/CH
09:55 Perfusion induced chemoresistance increase in multicellular pleural cancer
spheroids cultured on a microfluidic chip
J. Ruppen, E. Marconi, University of Bern/CH; R. Schmid, R. Peng, T.M. Marti, University
Hospital of Bern/CH; O. Guenat, University of Bern/CH
10:05 Human 3D osteosarcoma models for drug testing
M. Rimann, S. Laternser, Zurich University of Applied Sciences, Wädenswil/CH;
J.M. Kelm, InSphero AG, Schlieren/CH; A. Gvozdenovic, R. Muff, B. Fuchs, University
Hospital Balgrist, Zurich/CH; U. Graf-Hausner, Zurich University of Applied Sciences,
Wädenswil/CH
10:15 A novel 3D human airway model for oncology research
C. Mas, S. Huang, L. Wisniewski, S. Constant, OncoTheis, Geneve/CH
10:25 Coffee Break
Engineering of 3D models
Chair U. Graf-Hausner, Zurich University of Applied Sciences, Wädenswil/CH
11:00 Keynote Lecture
Development and application of alternative methods in the chemical industry
T. Ramirez, BASF SE, Ludwigshafen/D
11:45 Laser-assisted bioprinting (LaBP) as a sophisticated means to create a
three-dimensional skin equivalent
S. Michael, H. Sorg, Hannover Medical School/D; L. Koch, Laser Centre Hannover/D;
C.T. Peck, Hannover Medical School/D; A. Deiwick, Laser Centre Hannover/D; V. Coger,
Hannover Medical School/D; B. Chichkov, Laser Centre Hannover/D; P.M. Vogt,
K. Reimers, Hannover Medical School/D
12:05 A 3D skin sensitization model: KeratinoSens cells in RHE
S. Mathes, B. Striegl, Zurich University of Applied Sciences, Wädenswil/CH; A. Natsch,
R. Emter, T. Haupt, Givaudan, Dübendorf/CH; P. Girling, CELLnTEC, Bern/CH;
U. Graf-Hausner, Zurich University of Applied Sciences, Wädenswil/CH
12:15 An innovative bio-printing platform to engineer lung tissue
L. Horvath, University of Fribourg, Marly/CH; M. Thurner, regenHU Ltd.,
Villaz St. Pierre/CH; C. Jud, A. Fink, B. Rothen-Rutishauser, University of Fribourg,
Marly/CH
12:25 Differentiated and reproducible cell models of the airway epithelium through
computer-controlled air-liquid interface cultivation
M. Aufderheide, J. Rach, Cultex Laboratories GmbH, Hannover/D
12:35 High-throughput manufacturing of human epidermal models
A. Traube, M. Walter, L. Schober, Fraunhofer IPA, Stuttgart/D; F. Groeber, H. Walles,
Fraunhofer IGB, Stuttgart/D; K.R. Mewes, Henkel AG & Co. KGaA, Düsseldorf/D;
A. Traube, Fraunhofer IPA, Stuttgart/D
12.45 Lunch
From stem cells and primary cells to disease models
Chair H. Hauser, Helmholtz Centre for Infection Research, Braunschweig/D
14:00 Keynote Lecture
Human pluripotent stem cells: cardiac and vascular disease in a dish
C.L. Mummery, Leiden University Medical Center/NL
14:45 Characterization of single and co-cultured human iPSC-derived cardiomyocytes and
cardiac fibroblasts in scaffold-free 3D microtissues
P. Beauchamp, Bern University/CH; W. Moritz, I. Agarkova, J. Kelm, InSphero AG,
Schlieren/CH; N. Ullrich, Bern University/CH; T.M. Suter, C. Zuppinger, Bern University
Hospital/CH
15:05 Towards improved predictability in pre-clinical research: human dopaminergic 3D in
vitro model for development of gene delivery strategies
D. Simão, C. Pinto, ITQB-UNL / IBET, Oeiras/P; S. Piersanti, Biomedical Science Park
San Raffaele / Sapienza University of Rome/I; P. Fernandes, M. Serra, A.P. Teixeira,
ITQB-UNL / IBET, Oeiras/P; A. Weston, Cancer Research UK, London/UK; S. Ibanes,
A. Gennetier, Institut de Génétique Moléculaire de Montpellier/F; L. Collinson, Cancer
Research UK, London/UK; I. Saggio, Biomedical Science Park San Raffaele / Sapienza
University of Rome/I; G. Schiavo, Cancer Research UK, London/UK; E.J. Kremer,
Institut de Génétique Moléculaire de Montpellier/F; P.M. Alves, C. Brito, ITQB-UNL / IBET,
Oeiras/P
15:25 Functional immortalized cell lines for development of bioassays in 2D and 3D
T. May, R. Schucht, J. Zauers, InSCREENeX GmbH, Braunschweig/D; J. Schwerk,
M. Köster, Helmholtz Centre for Infection Research, Braunschweig/D
15:35 Assessing the 3D in vitro physiology of biopsy derived primary hepatocytes
U. Fernekorn, J. Hampl, F. Weise, M. Klett, A. Läffert, K. Friedel, A. Schober, Ilmenau
University of Technology/D
15:45 Coffee Break
Complex 3D cultures
Chair U. Marx, TU Berlin/D
16:15 Keynote Lecture
Engineering of human 3D vascularised tissues including disease models
H. Walles, University Hospital of Würzburg/D
17:00 3D angiogenesis assays in fibrin matrices
V. Charwat, University of Natural Resources and Life Sciences, Vienna/A; P. Hofbauer,
W. Holnthoner, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology,
Vienna/A; C. Kasper, University of Natural Resources and Life Sciences, Vienna/A
17:10 Stop or go? Studying nanomaterial translocation and behavior at the human placental
barrier using ex vivo and in vitro model systems
T. Buerki-Thurnherr, P. Manser, Empa, St. Gallen/CH; S. Grafmüller, University Hospital
Zurich/CH; C. Muoth, Empa, St. Gallen/CH; H. Annaheim, Zurich University of Applied
Sciences, Wädenswil/CH; W. Jochum, P.A. Diener, Cantonal Hospital St. Gallen/CH;
U. von Mandach, University Hospital Zurich/CH; P. Wick, Empa, St. Gallen/CH
17:30 Tooth formation in vivo and in vitro
J. Binder, J. Bräunig, R. Lauster, M. Rosowski, TU Berlin/D
17:50 Development of stabilised aligned CNS co-culture technology to model the behaviour
of a range of neural cell types
C. O'Rourke, A.J. Loughlin, Open University, Milton Keynes/UK; R. Drake, TAP
Biosystems, Royston/UK; J.B. Phillips, UCL, London/UK
18:00 End of Lecture Programme of Day 2
19:30 Conference Dinner at Greiffenegg Schlössle
Enabling technologies
Chair R. Pörtner, Hamburg University of Technology/D
09:00 Keynote Lecture
Rapid discovery of specific 3D culture matrixes for difficult-to-culture cell types
M. Lütolf, EPFL, Lausanne/CH
09:45 Skin bioprinting: an approach to produce standardized skin models on demand
M. Rimann, E. Bono, H. Annaheim, M. Bleisch, Zurich University of Applied Sciences,
Wädenswil/CH; M. Kuster, M. Thurner, regenHU Ltd., Villaz-St-Pierre/CH; C. Meier,
A. Bossen, Bern University of Applied Sciences, Biel/CH; U. Graf-Hausner, Zurich
University of Applied Sciences, Wädenswil/CH
09:55 Miniaturised artificial lymph node reactor - construction and validation of a 3D cell
culture device
A. Böhme, L. Radke, F. Schütze, C. Rogge, T. Liebscher, A. Foitzik, M. Frohme,
University of Applied Science Wildau/D; C. Giese, ProBioGen AG, Berlin/D
10:05 Modular segmented flow-platform for 3D cell cultivation
K. Lemke, T. Förster, R. Römer, A. Grodrian, St. Wiedemeier, G. Gastrock, Institute for
Bioprocessing and Analytical Measurement Techniques, Heilbad Heiligenstadt/D
10:15 Development and integration of new microfluidic building blocks for long-term 3D
culture and analysis
H. Kleine-Brüggeney, L. van Vliet, F. Gielen, F. Hollfelder, University of Cambridge/UK
10:25 Fabrication of 3D cell structures using self-folding polymer films
L. Ionov, S. Zakharchenko, Leibniz-Institut für Polymerforschung Dresden e.V./D
10:35 Raman spectroscopy for marker-free 3D-tissue analysis
K. Schütze, S. Koch, R. Gangnus, CellTool GmbH, Bernried/D; B. Mayer, O. Hoffman,
K. von Dehn-Rotfelser, Spherotec GmbH, Martinsried/D
10:45 Customized 3D cell culture image analysis via light sheet microscopy
D. Haumann, T. Schenker, C. Schmidt, S. Pfeiffer, da-cons GmbH, Eggenstein-
Leopoldshafen/D; F. Pampaloni, C. Mattheyer, E.H.K. Stelzer, BMLS Frankfurt/D
10:55 Coffee Break
Multi tissue organ systems
Chair U. Graf-Hausner, Zurich University of Applied Sciences, Wädenswil/CH
11:25 Keynote Lecture
Title tba
L. Griffith, MIT, Cambridge, MA/USA
12:10 The multi-organ-chip (MOC) - a universal microfluidic platform to co-culture
miniaturised organ equivalents at steady state
U. Marx, TU Berlin/D; M. Busek, Fraunhofer IWS, Dresden/D; A. Lorenz, E.M. Materne,
I. Wagner, K. Schimek, A. Ramme, TU Berlin/D; F. Sonntag, Fraunhofer IWS, Dresden/D;
R. Horland, TU Berlin/D
12:30 Connecting hanging drops in a microfluidic network for compound testing in
continuously perfused multi-tissue formats
O. Frey, P.M. Misun, A. Hierlemann, ETH Zurich, Basel/CH
12:50 Survey on current development trends in in vitro drug testing in Germany and
Switzerland
R. Pörtner, Hamburg University of Technology/D; I. Wagner, T. Atanasova, TU Berlin/D;
R. Gautam, Hamburg University of Technology/D; J. Gattlen, M. Rimann, E. Bono, Zurich
University of Applied Sciences, Wädenswil/CH; K. Rübberdt, K. Tiemann, DECHEMA e.V.,
Frankfurt/D; U. Graf-Hausner, Zurich University of Applied Sciences, Wädenswil/CH;
U. Marx, TU Berlin/D
13:10 End of Lecture Programme
13:10-14:00 Lunch
