| 09:00 -12:00 |
TUTORIAL WORKSHOP Target Identification – illuminating the interface between chemistry and biology (separate registration necessary) |
|---|---|
| 12:50 | Welcome |
| Chemical Biology of Natural Products | |
| 13:00 |
KEYNOTE LECTURE S. Quideau1 |
| 13:40 |
Exploration of chemical signals from microalgae that structure the marine environment G. Pohnert1 |
| 14:00 | Synthesis of a Brasilicardin A analogue featuring a simplified core P. Koch¹; M. Jung² ¹ Eberhard Karls Universität Tübingen/D; ² University of California, Los Angeles, Los Angeles/USA |
| 14:20 | Natural Products as Sources for the Rational Design of Small-Molecule Myosin Inhibitors M. Preller¹ ¹ Medizinische Hochschule Hannover/D |
| 14:40 |
KEYNOTE LECTURE 1 University of Frankfurt/D |
| 15:20 | Coffee break |
| 15:40 | Investigation of aglycon maturation in the biosynthesis of glycopeptide antibiotics C. Brieke¹; M. Peschke¹; K. Haslinger¹; M. Cryle¹ ¹ Max Planck Institute for Medical Research, Heidelberg/D |
| 16:00 | Development of inhibitors for the anti-infective target DXS using ligand-based virtual screening A. Hirsch¹ ¹ University of Groningen/NL |
| 16:20 | Soraphen A - targeting the membrane composition as an innovative approach to fight cancer K. Stoiber¹; A. Koeberle²; C. Händel³; S. Schmidt³; O. Werz²; J. Käs³; R. Müller⁴; A. Vollmar¹; S. Braig1 ¹ Universität München/D; ² University of Jena/D; ³ University of Leipzig/D; ⁴ Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken/D |
| 16:40 | Targeting human sulfation pathways J. Mueller¹ ¹ University of Birmingham/UK |
| 17:00 | Poster short lectures |
| 17:30 | Poster party |
| 20:00 | EVENING LECTURE Controlling biological function with photopharmacology D. Trauner1 |
| 20:40 | General assembly of the Joint Working Group Chemical Biology |
| 08:40 |
KEYNOTE LECTURE |
|---|---|
| 09:20 | Towards a comprehensive strategy to target identification for small molecule drug candidates M. Schirle1 1 Novartis Institutes for BioMedical Research, Inc., Cambridge, MA/USA |
| 09:40 |
Increasing biological relevance in vitro: From single microtissues to micro-physiological systems for substance testing 1 InSphero AG, Schlieren/CH |
| 10:00 | Integrating approaches for target identification and elucidation of mechanism of action in phenotypic drug discovery Y. Rudhard1, I. Sternberger1 1 Evotec AG, Hamburg/D |
| 10:20 | KEYNOTE LECTURE Chromobodies and the fluorescent 2-hybrid assay: new technologies to study proteins and protein interactions in living cells U. Rothbauer1 1 NMI Reutlingen/D |
| 11:00 | Coffee break |
| 11:20 | Chemical proteomics for cancer research G. Médard¹ ¹ Univertät München, Freising/D |
| 11:40 | Tracking drug action in living cells by thermal profiling of the proteome M. Savitski¹ ¹ Cellzome, Heidelberg/D |
| 12:00 | The power of unique CXCR3 allosteric modulators: probe dependence and bias signaling N. Tschammer¹ ¹ University of Erlangen-Nürnberg, Erlangen/D |
| 12:20 | Receptor derived peptides and peptide mimetics as chemokine inhibitors K. Schmitz¹; D. Helmer²; I. Rink¹; J. Dalton³; K. Brahm¹; J. Wack¹; P. Wadhwani²; G. Brenner-Weiss²; J. Giraldo3 ¹ TU Darmstadt/D; ² Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen/D; ³ Universitat Autònoma de Barcelona/E |
| 12:40 | Lunch break |
| 13:40 | KEYNOTE LECTURE Conformationally arrested peptidomimetics targeting outer membrane proteins in Gram-negative bacteria J. Robinson1 1 University of Zürich/CH |
| 14:20 |
Sigma hole bonding in kinase drug discovery F. Böckler11 University of Tübingen/D |
| 14:40 | Diverse chemistry to modulate 14-3-3 protein-protein interactions C. Ottmann1 1 TU Eindhoven/NL |
| 15:00 |
Genetic encoding of chemical tools to study G-protein coupled receptors |
| 15:20 | KEYNOTE LECTURE The discovery of inhibitors of the p53-MDM2 protein-protein interaction P. Furet1 1 Novartis Pharma AG, Basel/CH |
| 16:00 | Closing |
