The upcoming Advances in Chemical Biology conference will feature latest research from all hot topics in chemical biology. It covers the chemical biology of nucleic acids and proteins, peptides and carbohydrates and includes topics such as high-throughput assays, target identification, targeted synthesis concepts and phenotypic screening.
Lectures by young researchers and the posters exhibition will be at the heart of the conference. In addition to many inspiring invited lectures, the poster authors will have the opportunity to present their posters in a short lecture session.
On 26 January, a tutorial on proteolysis targeting chimeras (PROTACs) by Kurt Ritter will precede the lecture programme
The organizing committee invites you to submit abstracts of lectures and posters. Both junior and senior faculty are highly encouraged to submit contributions.
Extension of the deadline: You still have the chance to submit your abstract of lectures by 31 August 2020. Abstracts of posters can be submitted until 6 December, however, only abstracts submitted by 31 October will be included into the selection process for the posters lectures session.
We are looking forward to welcoming you in Frankfurt!
You are cordially invited to contribute to the scientific programme.
The upcoming Advances in Chemical Biology conference will be an on-site event. We expect the restrictions due to the COVID-19 pandemic to be lifted by then and we do hope that you could decide to submit abstracts of lectures by 31 August 2020. Abstracts of posters can be submitted until 6 December. However, only abstracts submitted by 31 October will be included into the selection process for the posters lectures session.
Please prepare 1-2 pages (incl. figures, max. size 1 MB, max. 2 pages). The abstract should explicitly mention objectives, new results and conclusions or significance of the work. Accepted abstracts will be published for all conference participants in a book of abstracts (PDF). The congress language is English.
Please use the Template to correctly format your contribution and upload it as PDF file.
Enter the author list (author and co-author/s) and affiliations in the same order as in your abstract. Please note: DECHEMA will not make any adjustments regarding the author information. The information will be used for the conference documents as given.
The selection of the presentations (lectures and poster) will be based on the review of the abstracts by the Scientific Committee.
Submit your abstract of lecture by 31 August 2020 at the latest:
Submit your abstract of poster by 31 October 2020 at the latest (latest chance for a poster lecture):
Submit you last minute poster by 6 December 2020 at the latest:
Would you like to promote the conference and tell others from our Call for Papers? Here you can download a poster for free:
The following deadlines are important for your contribution submission:
|31 August 2020|
|Programme at a glance||September 2020|
|Poster submission (important for a poster lecture!)||31 October 2020|
|Last minute poster||6 December 2020|
|Advances in Chemical Biology on site conference||26 - 28 January 2021|
|Industry||460 €||475 €|
|Academia||310 €||325 €|
|Students||190 €||205 €|
|Academia||230 €||245 €|
|Students||140 €||155 €|
1) No VAT requested according to § 4.22 UStG, registration fee may include Business Package with VAT.
2) Personal DECHEMA-, DPhG-, GBM-, GDCh-, VDI-GVC-members and EFC/EFCE passport holders; personal VAAM members
The DECHEMA terms and conditions for conferences apply. Please note that the following information are exerpts and supplements to the general terms and conditions.
Registration is possible, subject to capacity in the lecture rooms, up to the beginning of the conference. Confirmation of registration will be sent immediately by email. The invoice, with payment confirmation, you will receive by mail.
Editorial deadline for the list of participants is 5 January 2021.
The registration fees include conference ticket, book of abstracts and list of participants .
Cancellations are only accepted in writing (i.e. by fax, surface mail or e-mail).
Please find details about cancellation dates and fees in the general terms and conditions. In case of no-show the conference fees won't be refunded and fees not yet paid still have to be paid.
Tuesday, 26 January 2021, 9 -12 am
Dr. Kurt Ritter, Frankfurt/Main, Germany
PROTACs are heterobifunctional molecules hijacking the natural disposal system (ubiquitin -proteasome machinery) for proteins within a cell for specific degradation of a target protein (often referred as protein of interest = POI). The tutorial workshop aims to provide a step by step introduction in this fast-expanding research area.
After a look back at the “thalidomide tragedy” in the 60s, the key components of the natural protein degradation system in a cell will be introduced: ubiquitin as the basic unit for “tagging”, E1, E2 and E3 ligases as the involved “tagging enzymes” and the 26S proteasome as the “shredder” of a “tagged” protein. Their concerted action triggers the cellular degradation of no longer necessary proteins, an essential process for recovering amino acids. The drug thalidomide acting as a kind of “molecular glue” interfered with this process leading to the unintended erroneous degradation of certain cellular proteins in the fetus during pregnancy, the cause for the observed defects after birth.
The rational design of PROTACs, composed of a ligand to an E3 ligase and a ligand to the target protein (=POI) joined by a flexible linker, enables the intended knock-down of specific protein(s) within the cell. Thus, the heterobifunctional PROTAC recruits the target protein (= POI) close to an ubiquitinating E3 ligase, leading to its polyubiquitination and subsequent proteasomal degradation. Several binding motifs to various E3 ligases or their subunits (CRBN, VHL, IAP) have been added to the PROTAC toolbox by different research groups.
After a discussion about the advantages of PROTACs (“event-driven”) versus conventional small molecule drugs (“occupancy-driven”), several case studies for PROTACs aiming at the degradation of important disease-related proteins in cancer, inflammation or neurodegenerative diseases will be presented. Biochemical and biophysical assays as well as structure-based design using crystal structures of binary and ternary PROTAC complexes support the optimization of these PROTACs.
The first oral PROTACs, ARV-101 for treatment of prostate cancer, and ARV-471 for treatment of estrogen-receptor positive breast cancer, have progressed to clinical trials. Finally, existing hurdles and novel developments of this emerging modality will be discussed.
Richard Willstätter Prize for Chemical Biology
The Richard Willstätter Prize for Chemical Biology honours outstanding long-time achievements of an established scientist. Outstanding contributions and personal commitment to the field, e.g. the design of curricula and courses, widely used text books and media, promotion of young scientists, service on advisory boards and committees in Germany, and editorial services for scientific journals, are further indicators. The prize can also be awarded for technical developments, i.e. devices, methods, and processes, essential to obtain fundamental knowledge.
The Richard Willstätter Prize for Chemical Biology was founded by the DECHEMA Society for Chemical Engineering and Biotechnology, the German Pharmaceutical Society (DPhG), the Society for Biochemistry and Molecular Biology (GBM), and the German Chemical Society (GDCh) which equally contribute to the prize money. It comprises a certificate, the invitation to a plenary lecture and a sum of EUR 6,000.
Confirmed invited speakers (as of May 2020)
Dorothea Fiedler, FMP Berlin
Claudia Höbartner, University of Würzburg
Kai Johnsson, Max Planck Institute for Medical Research, Heidelberg
Johannes Krause, MPI for Human History, Jena
Stephan Sieber, TU Munich
Herbert Waldmann, Max Planck Institute of Molecular Physiology, Dortmund
Henrik Daub, evotec München
Christian Hackenberger, FMP Berlin
Anna Kathrin Hirsch, HZ Saarbrücken
Maja Köhn, Uni Freiburg
Kathrin Lang, Technische Universität München
Hans-Georg Lerchen, Bayer AG Wuppertal
Andreas Marx, Uni Konstanz
Andreas Marzinzik, Novartis Basel
Henning Mootz, Westfälische Wilhelms-Universität Münster
Stefan Raunser, Max-Planck-Institut für Molekulare Physiologie Dortmund
Andrea Rentmeister, Westfälische Wilhelms-Universität Münster
Pierre Stallforth, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, HKI, Jena
Roderich Süßmuth, TU Berlin
Dear lecture and poster authors, please note: Registration fee cannot be waived for authors. Please use the online registration. The registration will be opened in July 2020.
If you are unable to present your lecture for any reason, please let us know as soon as possible.
The official language of the conference is English. Simultaneous translation will be not available.
A video projector and a notebook (MS Office 2010, Adobe Acrobat Reader 9.3) will be provided. Please bring your lecture as PowerPoint or PDF-File on a USB stick. Nevertheless we kindly ask you to bring your own laptop computer as a backup.
In case that you need internet /special software for your presentation or if you have videos included into your file, please notify us in advance.
Each lecture is planned for a specific duration including discussion time. Strict timekeeping will be essential for the smooth running of the conference.
We suggest to use a minimum font of 24 pt for your presentation slides.
As a major guideline it is proposed to make the poster intelligible in itself, even in the absence of the author. It is suggested to divide the contents of each poster into introduction, results and conclusions, with a summary listing the pertinent results and conclusions.
The poster should be legible from a distance of 2-3 meters. Standard size for posters is 0.85 x 1.2 m (DIN A0-German Standard) vertically oriented. Therefore, please find the following specifications:
The posters will be shown throughout the whole conference. Please hang up your poster at the beginning of the conference.
Directions to DECHEMA: Please find a detailed description at www.dechema.de/location.
DECHEMA is located in a so called "Umweltzone" in the city of Frankfurt. If you intend to reach us by car, you need the corresponding green sticker on your car. More information available in German language at www.umweltzone.frankfurt.de.
Parking capacities at DECHEMA are very limited. Please use public parking lots along Theodor-Heuss-Allee: Congress-Center-Messe (CMF) or at the fair tower (Messeturm).
Going to DECHEMA by train? Use the joint offer from Deutsche Bahn (DB) and DECHEMA and travel to our events with reduced fares.
We recommend you the following hotels. We have not reserved any contingent of rooms. Please book a room by yourself. When using the booking code you will get a special rate.
Maritim Hotel Frankfurt (5 min walking distance)
60486 Frankfurt am Main
Phone: 0049 69 75 78-1134
Single room: around 108 EUR per night and incl. breakfast and wifi.
Please ask us for the booking code of the Maritim Hotel.
Mercure Hotel (10 min walking distance)
60486 Frankfurt am Main
Phone: 0049 69 7926 0
Single room: around 107 EUR per night and incl. breakfast and wifi.
You can book your rooms directly with the booking code "DECHEMA".
HOTEL FRANKFURT MESSE managed by Meliá Hotels International (15min walking distance)
60486 Frankfurt am Main
Phone: 0049 69 70730500
Single room: around 92 EUR incl. breakfast and wifi.
You can book your rooms directly with the booking code "DECHEMA" or 1277408 (Online-Booking)